Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"Metabolic Disorder"”.
-
Muscle disorder or metabolic disorder: genomic, transcriptomic, and metabolomic insights into the pathogenesis of wooden breast and white striping in commercial broiler chickens
… relatively recent emergence of several muscle disorders mainly affecting the pectoralis major muscle and severely impacting meat quality. Two such myopathies, wooden breast and white striping, are the focus of this dissertation due to their high prevalence and economic importance. Severe wooden …
-
The potential treatments of osteoporosis and hormone dysregulation caused by female athlete triad syndrome
Female Athlete Triad Syndrome (FAT) is a metabolic disorder that presents as a dysregulation of energy availability, menstrual functioning, and bone health. This condition impacts a growing number of female athletes. The triad of physiological and endocrine disruption can develop into conditions of …
-
Novel Diagnostic Approaches for Genetic and Environmental Sources of Mitochondrial Dysfunction
… that can prevent or reverse the deterioration of metabolic dysfunctions is critical to establishing early intervention. My research focused on investigating molecular targets linked with Friedrich's Ataxia, an inherited metabolic disorder, through conducting functional in-vitro studies using …
-
Proteomic profiling of skeletal muscle tissue from the Goto-Kakizaki rat model of type 2 diabetes.
… disposal in contractile tissues triggering metabolic dysregulation and glucotoxic side effects. The significance of skeletal muscle to T2D has prompted research into the perturbed glucose handling mechanisms in suitable animal models, such as muscle tissues from the spontaneously diabetic …
-
Metabolic engineering analysis of post-burn hepatic hypermetabolism
Metabolic engineering refers to the directed improvement of product formation or cellular properties through the modification of specific biochemical reactions or introduction of new ones with the use of recombinant DNA technology. It has been used to investigate and modify intermediary metabolism …
-
Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
Type 2 Diabetes Mellitus (T2DM), a metabolic disorder denoted by elevated blood glucose levels and insufficient insulin action, is growing in prevalence worldwide . Barriers to improving disease outcome resolve primarily around identifying and intervening during the preliminary stages of insulin …
-
Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
… exert positive impact on preventing and managing metabolic disorders, including NAFLD within the 2030 SDG. This review aims to evaluate the influence of dietary patterns on hepatic epigenetic gene modulation and provide dietary recommendations for the prevention and management of NAFLD in the …
-
How a structured exercise programme involving cardio and resistance exercise affects type 2 diabetes mellitus volunteers
Background T2DM is a metabolic disorder that is rapidly increasing in prevalence, it has become a 21st century epidemic and addressing this is one of the greatest global health challenges of our time. In the UK £10.3 billion or 10% of the NHS budget was spent on diabetes mellitus. It is essential …
-
Processing Speed and Executive Abilities in Children with Phenylketonuria
Objective: Phenylketonuria: PKU) is a hereditary metabolic disorder that often results in neuropsychological impairment, even in individuals treated early and continuously. This study was conducted to examine processing speed, variability in processing speed, and the relationship between processing …
-
Mechanisms and Diagnosis of Thrombosis in PCOS
… syndrome (PCOS) is the most prevalent endocrine-metabolic disorder in reproductive-age women, affecting 6-12% of women in the US. PCOS is characterized by hyperandrogenism, chronic anovulation, and polycystic ovaries, and has been linked to increased risk for thrombosis, a leading cause of …
-
Quantitative Analysis of Normal-Appearing White Matter In Pediatric Phenylketonuria
<p>Phenylketonuria (PKU) is a metabolic disorder that results in white matter abnormalities with varying degrees of severity. The analysis of brain structure in children with PKU using magnetic resonance imaging (MRI) has been limited by the reliance on qualitative data to characterize white matter …
-
A PREDICTIVE MODEL FOR DIABETES USING MACHINE LEARNING TECHNIQUES (A CASE STUDYOF SOME SELECTED HOSPITALS IN KADUNA METROPOLIS)
<p>Diabetes Mellitus (DM) which refers to a metabolic disorder that occurs when the level of blood sugar in the body is considered high, which could be a resulting effect of inadequate availability of insulin in the body. It is a chronic disease which may lead to myriads of complications in the …
-
Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
<p>Obesity is a multifaceted metabolic disorder with severe worldwide public health consequences. While obesity can often be treated using diet and exercise, there are complex genetic interactions driving obesity that don’t always respond to such changes. One important research focus for addressing …
-
The Association of Adipokines and Insulin Resistance in Women with Polycystic Ovarian Syndrome
A metabolic disorder with increasing concern to premenopausal women is Polycystic Ovarian Syndrome (PCOS). PCOS leads to numerous health-related concerns, including insulin resistance. The cause of insulin resistance in women with PCOS is unknown, but adipokine levels may play a role. PURPOSE: The …
-
The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
<p>Osteoporosis is the most common bone metabolic disorder, affecting over 200 million people globally. It is characterized by bone mass depletion and microarchitectural deterioration, leading to bone fragility and susceptibility to bone fracture. Genetic factors, estrogen deficiency, and …
-
The hypothalamic role of BACE1 in energy homeostasis
… by chronic stress (e.g. hypoxia, oxidative and metabolic) also associated with obesity and T2DM. Thus, impaired glucose homeostasis and insulin resistance is common to all three disease states, suggesting that BACE1 and Aβ may contribute to the progression of metabolic disease. Consequently, …
-
Assessing Nutrient Composition of Skimmed Human Milk for Treatment of Chylothorax and Very Long-Chain Acyl-CoA Dehydrogenase Deficiency Patients
… deficiency is an inherited autosomal recessive metabolic disorder of fatty acid oxidation, and chylothorax is a condition where chyle accumulates in the chest cavity; both conditions require fat restriction as a treatment. Human milk feeding is encouraged for newborns but may be discontinued …
-
Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
… and the same microRNAs in a mouse model of metabolic syndrome, as metabolic syndrome is one of the major risk factors for the development of AD. These animals had previously demonstrated memory deficits when raised on a high-fat diet. Cognitively impaired human subjects showed relative …
-
Investigation of a novel intein-based Escherichia coli expression system for human methylmalonyl CoA mutase : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry
… hMCM results in the rare, potentially fatal metabolic disorder methylmalonic acidemia. An experimentally determined structure of hMCM would add to the understanding of both the mechanism of catalysis and the molecular basis of some of the mutations underlying methylmalonic acidemia. The …
-
Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
Rett syndrome (RTT) is a progressive neuro-metabolic disorder caused by mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2). After a period of seemingly normal post-natal development, RTT patients experience a developmental regression, consisting of loss of acquired verbal and …
Page 1 of 3