Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 117 for “"Metabolic Disease"”.
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… which are caused by germline mutations in metabolic enzymes and nutrient transporters, provide an opportunity to observe how discrete metabolic defects cause human disease. Glycogen Storage Disease Type 1a (GSD1a), or von Gierke's disease, is an autosomal recessive IEM caused by defects in …
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Integrated Microvascular Flow Regulation and the Impact of Metabolic Disease
The growing prevalence of metabolic diseases poses a significant challenge to public health. One of the steadily emerging challenges facing individuals suffering from chronic metabolic disease is the development of cardiovascular diseases. While cardiovascular diseases may affect any part of the …
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Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
… a global epidemic of obesity and obesity-related metabolic disorders, such as metabolic syndrome and type-2 diabetes mellitus. While many factors contribute to the aetiology of these conditions, hypoxia is increasingly appreciated to be an important feature of obese tissues, and may be key to the …
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Molecular Mechanisms Governing the Pharmacology of LDT409 for the Treatment of Metabolic Disease
The prevalence of metabolic diseases, including obesity, dyslipidemia, and type 2 diabetes, is dramatically increasing in the world; thus, it is important to develop effective, low cost, and safe medications to treat these diseases. The peroxisome proliferator-activated receptors (PPARa/g/b) are …
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The role of high density lipoprotein compositional and functional heterogeneity in metabolic disease
… (HDL-C) and the incidence of cardiovascular disease (CVD). Clinically, HDL-C is often measured and used in combination with low density lipoprotein cholesterol (LDL-C) to assess overall cardiovascular health. HDL have been shown to possess a wide variety of functional attributes which likely …
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Berries in Prevention of Metabolic Disease – focus on obesity, diabetes and gut microbiota
… is associated with increased risk of several metabolic disorders including insulin resistance, nonalcoholic fatty liver disease and type 2 diabetes. Hence, there is a great need to identify dietary strategies for the prevention of obesity and related diseases. This thesis investigates the …
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The Role of OSTα-OSTβ and Bile Acid Transport in Intestinal Disorders Aand Metabolic Disease
… to the pathophysiology and progression of disease. Although bile acids are synthesized in the liver, bile acid transporters located throughout the enterohepatic system (kidneys, liver, gallbladder, intestine) are critical for maintenance of the bile acid pool and for bile acid homeostasis. …
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The Effect of Aberrant Inflammation During Pregnancy on Subsequent Risk of Maternal Metabolic Disease Development
… are linked to an increased development of metabolic disease in mothers and their offspring. Previous studies from our lab have shown the development of risk factors for disease development following pregnancy complications. It is thought that pregnancy complications prime the maternal …
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Sex-Based Differences in Mortality and Metabolic Disease in Subadult Skeletal Assemblages of Tell Hisban
… effects of sex on the risk of dying with active metabolic disease. This project uses dental proteomics to estimate the sex of 16 infants (up to 3 years of age) dying with (n=10) and without (n=6) skeletal lesions indicative of vitamin C deficiency, in addition to 8 modern control samples of known …
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Positioning Microtissues on the Differentiation Continuum Reveals their Utility for Studying Skeletal Myopathies and Metabolic Disease
… In parallel, we benchmarked the functional and metabolic properties of microtissues relative to 2D myotubes and native muscle. These findings identify a hurdle for the development of a multiplex microtissue-based T2D model while also delivering a comparative framework to guide platform selection …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
… by environmental cold challenge yields strong metabolic benefit in the face of diet-induced obesity (DIO). Yet, a critical barrier to leveraging brown fat NST for therapeutic use against metabolic disease is that BAT is silenced and inactive at physiological ambient temperature conditions in …
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Effects of dietary stimulators of metabolism and mitochondrial biogenesis in vitro and in vivo: Implications for metabolic disease
… available dietary supplement on resting metabolic rate in humans as well as the metabolic and biochemical effects in vitro. Methods: Human rhabdomyosarcoma cells (RD) and mouse myoblasts (C2C12) were cultured under standard conditions and treated with various doses of a commercially …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… and many of them act as biomarkers, both for disease and system regulation. Many gut hormone peptides are secreted by enteroendocrine cells (EECs) and some, known as incretins, are released after a meal to control blood glucose and stimulate neuronal satiety. These are being studied as novel …
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Effects of a higher protein weight loss diet on body composition, metabolic disease risk and physical function in postmenopausal women
… and are linked to an increased risk for metabolic disease and declines in physical function in older women. Higher protein intake under caloric reduced conditions eliciting weight loss may augment fat mass (FM) loss, which can reduce metabolic disease risk; and attenuate LST loss, which …
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Whole-Body Metabolic Flexibility is Discordant with Skeletal Muscle Metabolism
Metabolic disease continues to be a worldwide problem that affects all ages, sexes, and socioeconomic statuses. The development of metabolic disease is multifactorial with both genetic and environmental components. Because of this, interest has grown in the early identification of individuals …
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Risk factors for non-communicable disease and healthcare expenditure in South African employees with private health insurance presenting for health risk appraisal
… with other risk factors for noncommunicable disease (NCD), with specifically cardiovascular and metabolic disease, and whether these risk factors were associated with higher healthcare costs.
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Body Temperature and Diet As Drivers of Obesity Development
<p>Metabolic disease and obesity affect millions of individuals worldwide and the prevalence of obesity is expected to continue to rise. Mechanisms underlying diet-induced metabolic disease and obesity are complex and are largely unknown. In this dissertation research, we aimed to make advances …
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Role of TGR5 in Bile Acid Metabolism
… is an attractive drug target for treating human metabolic disease. However, TGR5 is highly expressed in the gallbladder, where its function is less well-characterized. In addition, Tgr5-/- mice are resistant to cholesterol gallstone disease (CGD), although the mechanism is poorly understood. …
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