Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 5058 for “"Metabolic"”.
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Systems metabolic engineering through application of genome-scale metabolic flux modeling
Systems metabolic engineering has enabled systematic studying of microbes for modifying their genetic contents, analyzing their metabolism, and designing new capabilities. One of the most commonly used approaches in systems metabolic engineering involves genome-scale metabolic flux modeling. These …
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Context-specific metabolic predictions
… molecules. Cells regulate the activity through metabolic reactions in a context-specific way; only reactions that are required in a cellular context, e.g., cell type, developmental stage or environmental condition, are usually active, while the rest remain inactive. The context-specificity of …
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Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
… applying innovative approaches for identifying metabolic drug targets in resistant pathogenic bacteria. In this thesis, genome-scale metabolic modelling (GSMM) was applied to identify antimicrobial drug targets. Experimental data from transposon mutant libraries grown in presence of tilmicosin, …
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Metabolic Cost of Hatha Yoga
No abstract prepared.
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Metabolic Bioactivity of Athrixia phylicoides
BACKGROUND: Insulin resistance is a major risk factor for the development of type 2 diabetes (T2D). It is characterized by insufficient response to secreted insulin in target tissues. In vitro studies demonstrated the ability of an aqueous extract of Athrixia phylicoides to increase glucose uptake …
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Metabolic Regulation of Cellular Signaling
… system, we have previously characterized a novel metabolic regulation of cell death. We found that glucose-6-phosphate (G6P) via the pentose phosphate pathway leads to increased nicotinamide adenine dinucleotide phosphate (NADPH) levels, a subsequent increase in cytosolic acetyl-coenzyme A and …
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Metabolic versatility of verrucomicrobial methanotrophs
Contains fulltext : 239946.pdf (Publisher’s version ) (Open Access)
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The dynamics of metabolic regulation
… variable environments and perturbations. Since metabolic regulation occurs at multiple time scales and involves diverse molecular mechanisms, understanding and manipulating the dynamics of metabolism in the cell constitutes an open challenge in systems biology. The work presented in this …
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Metabolic heterogeneity in microbial populations
… how variability in the copy numbers of metabolic enzymes affects how individual cells extract nourishment from their environment and grow. We model independent microbial cells, each with their own set of enzyme copy numbers sampled from experimental distributions, and use flux balance …
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Metabolic Regulation of Circadian Timekeeping
… of the relative flux through early primary metabolic pathways. This is accompanied by the development and optimisation of a microfluidic system for long-term perfused tissue culture, which allows for longitudinal study of metabolic flux within the same population of cells with simultaneous …
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Metabolic pathways of Campylobacter fetus
The energy metabolism of three strains of Camplyobacter fetus (i.e., C. fetus ss. fetus 482, C. fetus ss. intestinalis PB1, and C. fetus ss. jejuni H840) was investigated. A biphasic culture technique was employed to grow the culture, and from which crude cellular extracts were prepared. The growth …
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Nox4 mediates metabolic stress responses
… a wide variety of chronic skeletal muscle and metabolic-related diseases, including diabetes and sarcopenia. Even in patients with advanced skeletal muscle-related diseases, exercise is a well-established method to improve skeletal muscle mitochondrial metabolism, culminating in enhanced …
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Modeling photosynthesis and related metabolic processes : from detailed examination to consideration of the metabolic context
… cycle, those suitable for development of metabolic engineering strategies were identified. Driven by the question why starch rather than sucrose is the predominant transitory carbon storage in higher plants, the metabolic costs for their synthesis were examined. The incorporation of the …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… could contribute to various liver diseases and metabolic disorders. Therapeutic approaches targeting bile acid signaling have been developed for the treatment of nonalcoholic fatty liver disease (NAFLD). Bile acid receptor Farnesoid X receptor (FXR) agonists have been shown to ameliorate …
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Understanding liver metabolic effects of estrogens and liver niche-related metabolic changes in metastatic breast cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Metabolic influences on ageing in Caenorhabditis elegans: A time series multi-omics and metabolic modelling study
… lifespan and promote healthspan are known to be metabolic and relate to managing the balance of energy availability to optimise resource usage and survival during times of scarcity. The model organism Caenorhabditis elegans, a small transparent nematode worm that ordinarily lives in the soil and …
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A metabolic lens on phytoplankton physiology
… in other phytoplankton. Finally, we compared the metabolic changes of several distinct phytoplankton groups to uncover possible adaptation and acclimations that distinguish them. This analysis revealed several pathways and metabolites that represent the studied groups. The contributions of these …
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Unravelling the complexity of metabolic networks
… in various types of biological networks. Metabolic networks, in particular, play a fundamental role, since they provide the building blocks essential for cellular function, and thus, have recently received a lot of attention. In particular, recent studies have revealed a number of …
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Regulation of Metabolic Stress-Induced snoRNAs
… gene accumulate in the cytosol during metabolic stress, suggesting that these non-coding RNAs function non-canonically to target cytosolic RNAs. Moreover, we demonstrate that the <italic>rpL13a</italic> snoRNAs play a critical role in vivo in amplification of reactive oxygen species and …
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