Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Met receptor"”.
-
A mechanism of activation of c-MET receptor tyrosine kinase
c-MET receptor tyrosine kinase-mediated signaling governs numerous important cellular responses including cellular proliferation, differentiation, migration and apoptosis. Deregulation of these signals result in malignant behaviors, often leading to cancers. While the identity of the many signaling …
-
REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER
… by the lack of estrogen and progesterone receptors as well as normal expression of the human epidermal growth factor receptor 2 (HER2). These cellular properties thereby exclude patients diagnosed with TNBC from the benefits of current targeted agents. The aggressive nature of TNBC coupled …
-
Untersuchungen zum c-met/HGF-System an humanen Mesothelzellen in vitro
… mesothelial cells, in vitro, expressed the c-met receptor and their sensitivity to stimulation with recombinant HGF. RT-PCR and Western Blot was used to show c-met-receptor-expression of human mesothelial cells. It was shown that mesothelial cells stimulated with HGF colonize an „in vitro …
-
Untersuchungen zur Wirkung des Hepatocyte Growth Factor (HGF) auf Humane Omentum Majus Zellen
… (HOMC), according to their expression of the c-met receptor, the secretion of the fibrinolytic enzyme t-PA (tissue-plasminogen-activator) and the secretion of the antifibrinolytic enzymes PAI-1 and PAI-2 (plasminogen-activator-inhibitor 1 and 2). Furthermore the influences on proliferation and …
-
Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
… is a truncated extracellular mutant of the EGF receptor (EGFR) that is commonly found in GBMs and confers tumorigenic behavior. Although much work has been done over the past decade to elucidate pathways involved in EGFRvIII receptor signaling, the global map of the signaling networks that it …
-
A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
<p>Cancer cell metastasis is the single most threatening occurrence of tumor progression and predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor tyrosine kinase (c-Met), integrin beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to …
-
Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… presentation of hepatocyte growth factor to the MET receptor by IdoA. Furthermore, DS-epi1-silenced cells had malfunctioning disassembly of adhesion complexes and abnormal cytoskeleton architecture. During brain development, DS-epi2 is known to be highly expressed. We generated a …
-
The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of various cells irrespective of ligand stimulation, but neither the specific amino acid motif nor the responsible nuclear localization signal (NLS) has not been previously reported. Here, we report that two …
-
Green Tea Polyphenol Epigallocatechin-3-gallate Inhibits Hepatocyte Growth Factor-Induced Tumor Cell Migration and Invasion In Vitro and In Vivo
" 간세포성장인자(hepatocyte growth factor,HGF)와 그 수용체인 Met의 과 활성화는 많은 종류의 종양의 발생과 진행에 관여하는 것으로 알려져 있다. 본 연구에서는 HGF/Met 신호전달체계를 효과적으로 억제하는 물질을 찾아보고자하였고 녹차의 성분 중 생체에 영향을 주는 중요한 polyphenol인 Epigallocathechin-3-gallate(EGCG)가 HGF/Met 신호체계를 효과적으로 억제할 수 있다는 것을 발견하였다. EGCG는 HGF에 의한 Met의 활성 방식이 autocrine이든 …
-
Basis For Targeting Met Activation Mediated Resistance to Pi3K Inhibition In Breast Cancer
… such as those targeting the PI3K pathway and the MET receptor, has the potential to benefit a significant number of patients with breast cancer. In this study we hypothesized that <strong>concurrent aberrations </strong>in <em>PI3K</em> and <em>MET</em> will render breast cancers resistant to …