Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Mesothelin"”.
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Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
… Pancreatic tumors over-express the protein mesothelin, and therefore, it is used as a tumor target antigen for vaccine development. Our current research uses an improved Modified Vaccinia Ankara poxvirus that we developed to express mesothelin to the murine immune system to treat pancreatic …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… Trophoblast cell surface antigen 2 (TROP2) and mesothelin (MSLN), which are overexpressed in cervical cancer cells. Targeting TROP2 and MSLN presents a promising therapeutic approach. The study aimed to develop novel recombinant anti-TROP2 and anti-MSLN immunotoxin candidates based on truncated …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
… Targeted phagocytosis and clearance of CD19+, mesothelin+, and HER2+ cells by CARs targeted against each respective antigen was significantly superior to that by control untransduced (UTD) macrophages. Importantly, CAR macrophages were capable of polyphagocytosis and serial phagocytosis of …