Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Mesolimbic dopamine system"”.
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… MPH is a psychostimulant that inhibits the dopamine (DA) and norepinephrine (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the effects of high-dose, chronic MPH exposure have not been well defined. In particular, …
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Phasic Dopamine Signaling During Ingestion: Modulation Across the Need-to-Satiety Arc
… aimed at consuming the needed stimulus. The mesolimbic dopamine system plays a key role in driving and reinforcing such behaviors. While it is well established that physiological need states potentiate dopamine responses to relevant stimuli, less is known about how ongoing ingestion and the …
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Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… of maternal behavior in juvenile offspring. The mesolimbic dopamine system is also critically implicated in adult maternal behaviors, and was hypothesized to be responsive to variation in maternal LG. A second series of studies demonstrate that low or high levels of maternal LG predict levels of …
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Parkinson's disease and the influence of the forebrain dopaminergic system on dreaming
… by Solms (2000) to the effect that a forebrain dopaminergic mechanism is the final common path to dreaming. It was hypothesised that sufferers of Parkinson's disease (PO) would have decreased intensity and frequency of dreams - that is that PO disease may lead to cessation or reduced dreaming, …
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Lateral hypothalamic control of motivated behaviors through the midbrain dopamine system
… activation of the GABAergic component causes dopamine release downstream in the nucleus accumbens via disinhibition of VTA dopamine neurons through VTA GABA neurons. Together, these experiments have profoundly elucidated the functional roles of the individual circuit components of the greater …
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Cognitive Neurostimulation: Learning to Volitionally Invigorate Mesolimbic Reward Network Activation
<p>The brain’s dopaminergic system is critical to adaptive behaviors, and is centrally implicated in various pathologies. For decades, research has aimed at better characterizing what drives the mesolimbic dopamine system and the resulting influence on brain physiology and behavior in both humans …
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Hedonics, Reward Prediction, and Reinforcement Learning in Schizophrenia: Relationships to Anhedonia and Avolition
… This process is thought to be mediated by the mesolimbic dopamine system, which shows evidence of dysregulation in schizophrenia. We examined reward prediction using a Pavlovian paradigm with monetary reward, using fMRI to examine brain responses during reward anticipation and receipt. …
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Behavioural, Pharmacological, and Immunohistochemical Investigation of 50 kHz USVs as an Expression of Positive Emotional Arousal in the Long Evans Rat
… such calling could be blocked by antagonism of dopamine receptors. In chapter 4, I utilized microinjections of dopamine into the shell of the nucleus accumbens to establish that dopamine is sufficient to induce 50 kHz USVs. Additionally, my findings from chapter 4 supported the observed …
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Investigation of the role of the nucleus accumbens in amphetamine-induced 50 kHz ultrasonic vocalizations in the rat
There is extensive evidence that the mesolimbic dopamine system underlies the production of 50 kHz ultrasonic vocalizations in rats. In particular, the shell of the nucleus accumbens is associated with generation of frequency modulated 50 kHz calls (a specific type of 50 kHz call which can be …
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Interactions between the cholinergic and dopaminergic system during the production of ultrasonic vocalizations in rats
… agents injected into the ascending mesolimbic cholinergic system that terminates in the anterior hypothalamic-preoptic area (AH-MPO) and lateral septum (LS). The other group of USVs contains 50-kHz USVs, characterized by high peak frequency, ranging from 39 to 90-kHz, short duration …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… and relapse, possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this hypothesis, our initial studies measured alterations in cAMP-dependent and -independent protein phosphorylation in vivo produced by chronic cocaine and heroin …