Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Mesolimbic"”.
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Cognitive Neurostimulation: Learning to Volitionally Invigorate Mesolimbic Reward Network Activation
… aimed at better characterizing what drives the mesolimbic dopamine system and the resulting influence on brain physiology and behavior in both humans and animals. To date, the dominant modes of research have relied on extrinsic approaches: pharmacological manipulations, direct brain stimulation, …
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INVESTIGATING SEX DIFFERENCES IN THE TRANS-SYNAPTIC REGULATORS OF MESOLIMBIC DRIVEN PALATABLE FOOD INTAKE
… strategy to trace upstream afferents of the mesolimbic pathway in male and female rats. Surprisingly these experiments revealed different afferent pathways in male and female groups. Female afferents of the mesolimbic pathway were labeled: BNST VTA NAcSh, while male afferents labeled: LSN …
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Prolactin Effects on Nigrostriatal and Mesolimbic Dopaminergic Neurons: In Vivo and In Vitro Studies
… the effect of prolactin on nigrostriatal and mesolimbic dopaminergic neuronal activity and its possible regulatory mechanism were examined.
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Vulnerability and Resilience to Social Defeat: The Role of Neuroplasticity Within the Mesolimbic Dopamine Circuit
… we identify signature adaptations within the mesolimbic dopamine circuit that are uniquely associated with vulnerability and, by a combination of viral-mediated gene transfer and genetic mouse models, we demonstrate how these adaptations are causally linked to a vulnerable phenotype. We also …
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… many points of interaction, particularly in the mesolimbic DA system, an area associated with the rewarding and reinforcing properties of drugs. Thus, our studies focused on the interactions of DA and 5-HT systems at the level of the ventral tegmental area (VTA) and nucleus accumbens (NAc) …
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Assessment of Ethanol and Nicotine Interactions in the Rat Model: Pharmacotherapeutics, Adolescence, and the Mesolimbic System
Alcohol use disorder (AUD) and nicotine dependence often result in serious health problems and are top contributors to preventable deaths worldwide. Co-addiction to alcohol and nicotine is the most common form of polysubstance abuse. Epidemiological studies indicate that more than 80% of …
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Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… of maternal behavior in juvenile offspring. The mesolimbic dopamine system is also critically implicated in adult maternal behaviors, and was hypothesized to be responsive to variation in maternal LG. A second series of studies demonstrate that low or high levels of maternal LG predict levels of …
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Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
… locomotion has been adopted as a model of raised mesolimbic dopamine function. These models have been used to study drugs which are effective in the treatment of schizophrenia. Only locomotion is reliably antagonised by all classes of antipsychotic drugs, although it has been hypothesised that, …
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EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS
… may come from overexpression of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking dopamine receptors. …
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Stimolazione da etanolo del sistema dopaminergico mesolimbico: ruolo dell'acetaldeide
… the firing of Ventral Tegmental Area (VTA) mesolimbic dopaminergic neurones (2,3). Moreover, recent data show that ACD blockade by sequestration with D-penicillamine or by alcohol dehydrogenase competitive inhibition with 4-methylpyrazolean prevent various electrophysiological and behavioral …
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Interactions between the cholinergic and dopaminergic system during the production of ultrasonic vocalizations in rats
… agents injected into the ascending mesolimbic cholinergic system that terminates in the anterior hypothalamic-preoptic area (AH-MPO) and lateral septum (LS). The other group of USVs contains 50-kHz USVs, characterized by high peak frequency, ranging from 39 to 90-kHz, short duration …
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Phasic Dopamine Signaling During Ingestion: Modulation Across the Need-to-Satiety Arc
… aimed at consuming the needed stimulus. The mesolimbic dopamine system plays a key role in driving and reinforcing such behaviors. While it is well established that physiological need states potentiate dopamine responses to relevant stimuli, less is known about how ongoing ingestion and the …
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Interazione dopamina-ossitocina nel controllo centrale della risposta erettile
… into the PVN on the release of dopamine by mesolimbic dopaminergic neurons in the “shell” of the nucleus accumbens; 2) the effect of oxytocin injected into the VTA on penile erection and on the concentration of dopamine into the “shell” of the nucleus accumbens and into the PVN; 3) the …
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… the nucleus accumbens, the terminal region for mesolimbic dopamine neurons originating in the ventral tegmental area. The injection of atropine methyl nitrate into the ventral tegmental area elevated extracellular levels of dopamine and its metabolites in the ipsilateral nucleus accumbens. Thus …
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THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
… the activity of DAergic neurons throughout the mesolimbic, mesocortical and nigrostriatal DAergic pathways (Gobert et al., 1995; Tepper et al., 1997; Diaz et al., 2000). D3 deficient mice (D3R-/-) exhibit extracellular levels of dopamine twice as high as their wild-type (WT) littermates …
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THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE
Background: Mesolimbic dopamine controls drug and alcohol seeking behavior. Stimulation of dopamine D3 autoreceptor reduces extracellular levels of dopamine. We tested the hypothesis that dopamine D3 receptor (D3R) gene deletion or its pharmacological blockade counteracts alcohol preference and …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… measured in brain regions associated with the mesolimbic system after enzyme inhibitor treatments. THC, JZL184, and SA-57 all produced time-dependent reductions in ICSS that were mediated through CB1 receptors, as they were blocked by pre-treatment with the CB1 antagonist rimonabant, but not …
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Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury
… one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown.
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