Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Mesenteric arteries"”.
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Effects of an Endothelial Cell-specific PAR2 Knockout on Endothelium-dependent and -independent Relaxation of Mouse Arteries
… of vascular smooth muscle in resistance-type arteries. Further, we found that treatment of mesenteric arteries with inhibitors of cyclooxygenase and nitric oxide synthase combined, restored normalized acetylcholine-induced EDR in EC PAR2-/- mice. Therefore, reduced EDR in EC PAR2-/- mesenteric …
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Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: The role of endothelium-derived relaxing factors
… (EDRFs) in modulating vascular reactivity of mesenteric arteries taken from streptozotocin (STZ)-induced diabetic rats at early and intermediate stages of the disease (one and eight weeks, respectively). We also investigated the mesenteric expression of the mRNAs for endothelial nitric oxide …
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Role of magnesium ions in the excitation of vascular smooth muscle. Effects of hypermagnesaemia and hypomagnesaemia on drug-induced contractions of mammalian arteries with special reference to the involvement of changed tissue calcium ion concentration or distribution in the observed responses.
… in extracellular [Mg 2+] were studied in mesenteric arteries from weight matched normotensive and spontaneously hypertensive rats (SHR). No differences in response to NA or ATP when extracellular [Mg 2+ ] was either increased or reduced were observed in the SHR compared to the normotensive …
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The effect of sex on cardiovascular dynamics in normal and diabetic rates
… were placed on the iliac, renal and superior mesenteric arteries. A bolus infusion of L-NAME resulted in a rapid increase in MAP in normal females and males. However, in diabetic females and males this response was significantly lower and especially so in diabetic females. L-NAME decreased the …
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Bioactive Lipids in Nociception
… native TRPV1 on sensory nerve fibers in rodent mesenteric arteries and heterologously expressed rat and human TRPV1. The effects of 2-AG and the metabolically stable analog noladin ether were almost absent in TRPV1 gene-deficient mice. Stimulation of isolated rat dorsal root ganglia with the …
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Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling
… structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor …
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In hypertension do smaller holes in arterial internal elastic lamina lead to fewer routes for myoendothelial junctions and hence less EDHF response?
… lamina (IEL) affects this relationship in mesenteric and saphenous arteries. This was enabled by the study of functional and confocal microscopy dye transfer experiments. Normotensive (WKY) and hypertensive (SHR) rats of 12 weeks and 6 months of age were used to assess the effect of …
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Doppler ultrasound technique used to determine the blood flow viscosity in the middle cerebral artery of a canine animal model
… flow velocity in the femoral, left gastric and mesenteric arteries of a mouse (14.5cm/s to 17.4cm/s; 12cm/s to l4cm/s; 25cm/s to 30cm/s respectively), middle cerebral artery (MCA) of a pig (7.5cm/s to 8.5cm/s), the MCA of a dog (5.5cm/s to 6cm/s) and drug response as an indication of instrument …
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Investigating The Role Of Transient Receptor Potential Ankyrin One (TRPA1) In Cardiovascular Regulation
… Wire myography using murine TRPAl WT and KO mesenteric arteries showed cinnamaldehyde to cause concentration-dependent vasorelaxation comprising a TRPAl dependent component, which was endothelial independent and mediated by CGRP and hyperpolarisaton. Basal blood pressure monitoring by both …
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The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… further validated these findings using mouse mesenteric arteries in a pressure myograph system. We also have dissected another major signaling pathway initiated by apo(a) that involves in a disruption of adherens junctions in EC. In this pathway, apo(a)/Lp(a) activates the …
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Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy
… tyrosine kinase (RTK) activation. Pairs of rat mesenteric arteries were pressurized to 90 mmHg (control), and then one was raised to 140 mmHg for 1, 3, 5 or 10 minutes. Western blotting using phosphorylation-specific antibodies revealed that Src-pY<sup>418</sup> (autophosphorylation site) was …
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Imaging biological water permeability barriers using CARS microscopy
… what had previously been achieved in the rat mesenteric artery, likely due to their reduced wall thickness. Permeability mapping of these arteries localized the water permeability barrier to the endothelial basolateral membrane, a result consistent with previous measurements performed in the …
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Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm
… by prolonged severe constriction of arteries in the base of the brain, including the basilar artery. Spasmogens (serotonin, endothelin and vasopressin), elevated in response to SAH, induce persistent depolarization of the myocytes in the artery wall, leading to continuous influx of …
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Modulation of the vascular function by cannabinoids, calcitonin gene related peptide and connexin hemichannels
… cannabinoid methanandamide was present in small mesenteric rat arteries, we performed experiments on acutely isolated SMCs. Our findings show that the cannabinoid methanandamide fails to increase the membrane potassium (K+) currents and fails to hyperpolarize the membrane potential. Moreover, the …