Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Mesenchyme"”.
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Multiomic Atlasing of Human Mesenchyme Development
Development of human connective tissue, termed ‘mesenchyme’, is a dispersed process in utero involving a diversity of cell lineages across organ systems. Diseases of these cell lineages, including fibroblasts and cartilage, affect numerous organ systems throughout human lifespan, manifesting as …
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Fgf4 and Wnt5a/Pcp Signaling Promote Limb Outgrowth by Polarizing Limb Mesenchyme
… to observe the movement and morphology of limb mesenchyme cell cultures in the presence or absence of a Wnt5a expressing cell bolus. It appears as though the cells orient and move in a random fashion regardless of Wnt5a. However, this in vitro method may not truly recapitulate in vivo events. …
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The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
Epigenetic mechanisms play an important role during the morphogenesis of the hair follicle and the hair cycle. Work on hair regeneration is of importance as no products are available which can provide complete reversal of hair loss. Tet2 promotes DNA demethylation by the hydroxylation of 5mC to …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
Female ageing leads to reduced hair density and thinner fibres. The impact of the ageing dermal environment on the hair follicles (HFs) remains unclear. This study documents in situ changes in human female scalp skin of women (19-81 years (yrs)), and corresponding primary cultures of dermal …
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The role of Wt1 in Müllerian duct development
… deleted <em>Wt1</em> in the Müllerian duct (MD) mesenchyme using a novel conditional null reporter allele, <em>Wt1 flox-RFP</em>. This allele utilizes the Cre-lox system to delete exons 8 and 9 of <em>Wt1</em>, disrupting the DNA binding capability of the protein. Simultaneously, a nuclear red …
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Genetic Regulation of Müllerian Duct Regression
… testes, to its primary receptor AMHR2 in the MD mesenchyme. This is evidenced by experiments in which male knockout mice that did not express either <em>Amh</em> or <em>Amhr2</em> did not undergo MD regression. Thus, <em>Amh/Amhr2</em> are essential for male sex differentiation. A lack of MD …
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Identification of mesenchymal genes involved in prostate organogenesis by LongSAGE analysis
… concert with paracrine signalling from inductive mesenchyme to regulate epithelial growth and branching of the prostate. The ventral mesenchymal pad (VMP) is an area of inductive mesenchyme that is rich in regulatory growth factors of which few have been identified at present. Recently, the role …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… of interaction between the neural crest-derived mesenchyme and the conjunctival epithelium. The mesenchyme secretes the chemo-attractive signal of Fgf10, which binds to epithelial Fgfr2b and co-receptor heparan sulphate proteoglycans, to promote budding and branching morphogenesis of the lacrimal …
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An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam.
… transition (MET) in mouse periocular mesenchyme cells to drive them to form fully differentiated adult corneal endothelial cells in culture. Periocular mesenchyme surrounding the optic cup was dissected from E12.5 and E13.5 mouse embryos and immortalised with the SV40 large T-antigen. …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… tissues. During pancreas development, mesenchyme-derived structures induce specification, growth and differentiation of pancreatic epithelial cells. For instance, notochord, endothelial cells, and pancreatic mesenchyme are essential for the development of the pancreas. N-cadherin …
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Morphological investigations into the development of the mammalian corneal endothelium using the mouse model
The corneal endothelium (CE), a mesenchyme-derived tissue, is a monolayer of squamous cells on the inner corneal surface. In Foxc1-1• mice, the CE fails to form. The understanding of the cause of this defect has implications for the study of human eye disorders that are related to FOXC1 mutations. …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
… is thought to arise from undifferentiated renal mesenchyme. However, the differentiation status of cells in the mesenchyme that can give rise to Wilms tumors is unknown. Gene expression analysis of a large panel of Wilms tumor patients has identified different subsets of Wilms tumors that are …
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Dysregulation of Meox2 Following Wt1 Mutation In Kidney Development and Wilms Tumorigenesis
… and known or putative cellular functions. Mesenchyme homeobox 2 (<em>MEOX2</em>) was one of the most significantly upregulated genes in<em> WT1</em>-mutant WT. MEOX2 is known to play a role in cell proliferation, apoptosis, and differentiation. In addition to its biological roles, it is …
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A comparative immunohistochemical study of Ki-67 expression in adenomatoid odontogenic tumour, unicystic ameloblastoma and dentigerous cyst
… with mature fibrous stroma, without odontogenic mesenchyme. However these lesions, like odontomes, occur almost exclusively during the final period of odontogenesis, and clinically behave like self-limiting hamartomatous lesions. Histologically they seem to arise from the lining of dental …
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Multiple roles of epithelial signaling during craniofacial and foregut morphogenesis
… bud structure, composed of neural crest-derived mesenchyme and core mesoderm surrounded by pharyngeal epithelium. The mesenchyme needs to receive Hedgehog signaling for mandible development, but the epithelial tissue that signals to the mesenchyme has not been identified in mammals. Data …
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A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation
… we characterize FoxN2/3 in the primary mesenchyme cell (PMC) GRN. Expression of foxN2/3 begins in the descendants of micromeres at the early blastula stage; and then is lost from PMCs at the mesenchyme blastula stage. foxN2/3 expression then shifts to the secondary mesenchyme cells …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… particular neural crest-derived pharyngeal arch mesenchyme markers. Mice deficient for both Gaq and Ga 11 are phenotypically similar to EtA or Et-1-null mice. My analysis of expression patterns of Et-1 dependent and independent transcription factors in Gaq /G a11-deficient embryos revealed that …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… particular neural crest-derived pharyngeal arch mesenchyme markers. Mice deficient for both Gaq and Ga 11 are phenotypically similar to EtA or Et-1-null mice. My analysis of expression patterns of Et-1 dependent and independent transcription factors in Gaq /G a11-deficient embryos revealed that …
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THE ROLE OF NON-MUSCLE MYOSIN IN TENDON AND ATTACHMENT UNIT FORMATION AND MATURATION
… mice to specifically delete NM-II in Prrx1 (limb mesenchyme) or Scx (tenogenic) lineage cells. In Chapter 2, we found that deletion of the predominant NM-II isoforms, NM-IIA (Myh9 gene) and NMII-B (Myh10 gene) affected both the formation and maturation of the attachment unit. In particular, the …
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The Role of FGFR4 in Trigeminal Placode Cell Development
… would have normally begun migration into the mesenchyme. These results show that FGFR4 is involved in trigeminal placode cell delamination.</p>
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