Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Mesenchymal-to-epithelial transition"”.
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hCLCA2 IS A p53-REGULATED GENE REQUIRED FOR MESENCHYMAL TO EPITHELIAL TRANSITION IN BREAST
… suppressor hCLCA2 is a putative chloride regulator that is expressed in normal breast epithelial cells and frequently down-regulated in breast cancers. The first CLCA protein was described as a calcium-activated, plasma-membrane chloride channel having four or five transmembrane pass structure …
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An in vitro model of mouse corneal endothelial development Mohammed Mubeen Goolam.
The principle aim of this study was to derive an in vitro model that could be used to study corneal endothelial development. This was done by investigating methods to induce a mesenchymal-to-epithelial transition (MET) in mouse periocular mesenchyme cells to drive them to form fully differentiated …
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Novel Regulators of Somatic Cell Reprogramming
Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by expression of defined embryonic factors. My thesis is focused on exploring the mechanisms underlying reprogramming using a secondary mouse embryonic fibroblast model that forms iPS cells with high efficiency upon inducible …
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Investigating the control of epithelial polarisation in human kidney organoids
Polarised epithelial tubes make up the bulk of the functional domains of adult organs, and failures in either the development or maintenance of these structures is the basis of many adult pathologies, such as polycystic kidney disease. One of the key mechanisms of tube formation during development …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
The epithelial to mesenchymal transition (EMT) is a process that is essential for normal embryonic development as well as the healing of damaged adult tissues. In the context of cancer, oncogenic EMT induces enhanced invasion, survival and tumorigenicity which can promote disease progression and …
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INTEGRATION OF REDOX-REGULATED SIGNALING AND METABOLISM IN HEAD AND NECK CANCER
… as adjuvant treatment after surgery. Resistance to radiation therapy significantly impacts the ability to achieve local and regional remission to ultimately cure cancer. The disease heterogeneity, invasiveness and resistance to radiation constitute significant roadblocks for treatment and …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… at distant organs. Metastasis is often fueled by Epithelial-to-Mesenchymal Transition (EMT) that enables cells to migrate and invade, and its reverse Mesenchymal-to-Epithelial Transition (MET) that facilitates cells to shed migration and regain adhesion to colonize other organs. While undergoing …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
Epithelial to Mesenchymal Transition (EMT) and its reversal, via Mesenchymal to Epithelial Transition (MET), describes the highly coordinated cycle of epithelial plasticity by which normal tissues are remodelled and repositioned during development. Previous studies have characterised the role of …
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SYK promotes TGF-beta-induced P-body clearance in breast cancer cells through the enhancement of autophagy
… cells. Its expression, however, is not limited to immune cells. SYK is expressed in a variety of epithelial cell types and epithelial-derived tumors. Reports regarding the role of SYK expression in these diverse cell types and tumors have been opposing. In breast cancer, SYK expression has been …
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Kidney tubulogenesis in human renal organoids: an investigation into the contribution of the microtubule-associated protein DCDC2
… the metanephric mesenchyme repeatedly undergo a mesenchymal to epithelial transition (MET). This forms an initial tube which subsequently extends into the nephrons, which are the functional unit of the kidney. When kidney nephrons are lost due to disease or damage, kidney function is reduced …
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Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration
Analysis of metazoan genomes has led to the extraordinary observation that mammals contain only ~25000 protein-coding genes. Therefore, post-transcriptional gene regulatory mechanisms (PTGRMs) are thought to be crucial for generating the diverse proteome required to support their high cellular …