Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"Mesenchymal Stem Cells (MSCs)"”.
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Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are tissue culture plastic adherent cells that are able to differentiate into multiple cell types, modulate the immune system, and aid in wound repair. These versatile cells are thus being investigated to treat a wide variety of different diseases such as graft vs. …
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Toward understanding and mitigating heterogeneity in bone marrow stromal cell cultures for improved therapeutic efficacy
Bone marrow stromal cells (BMSCs), a subset of which are considered mesenchymal stem cells (MSCs), have been used in over 600 clinical trials for indications ranging anywhere from autism to liver cirrhosis to diabetes. They have cited enthusiasm in the cell therapy community not only for their …
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The Regulation of Bone Marrow Mesenchymal Stem Cells by Vascular Cell Adhesion Molecule-1
Bone marrow (BM) mesenchymal stem cells (MSCs) form specialized perivascular microenvironments or niches in the BM that regulate hematopoietic stem cell (HSC) function. Interactions between MSC niche factors and HSCs ensure hematopoietic homeostasis. Vascular Cell Adhesion Molecule-1 (VCAM1) is …
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Osseointegration potential for heat treated 3D Ti6Al4V scaffolds seeded with mysenchymal stem cells in vitro
… the seeding of 3D scaffolding structures with mesenchymal stem cells (MSCs) will improve the potential for osseointegration of the implants, as the existing bone may be more inclined to unite with developing bone than with the implant substrate. Titanium-6 Aluminium-4 Vanadium (Ti64) is one of …
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Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering
… a therapeutic growth factor via transfection of cells seeded or migrating within the scaffold. In vitro studies were performed to evaluate gene-supplemented CG (GSCG) scaffolds, including: 1) the type of expansion medium to use for growing chondrocytes prior to transfection, 2) methods of …
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Factors affecting neurogenesis after application of human mesenchymal stem cells in ischemic rat model
… trial of ex vivo culture expanded autologous mesenchymal stem cells (MSCs) in patients with severe ischemic stroke. We proposed that an optimal condition, for either donor or recipient, may exist and enhance the effects of the mesenchymal stem cells in those patients. Thus we evaluated the …
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The Application of Mesenchymal Stem Cell therapy on Multiple System Atrophy
Since disease progression in multiple system atrophy(MSA) is much faster and no drug treatment consistently benefits MSA patients in the long-term, neuroprotective or regenerative strategies are inevitable in the management of MSA patients. We divided two group, MSC-treated(n＝11) and control …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
<p>Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into several cell lineages, including mural cells, which surround and support blood vessels, and possibly endothelial cells, which form the blood vessel walls. In this study, we investigated the effects of basic …
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function
Mesenchymal stem cells (MSCs) are derived from bone marrow, and are capable of proliferating and differentiating along multiple pathways such as osteoblasts, chondrocytes and adipocytes. MSCs offer the means for regenerative therapies not possible with conventional small molecule/antibody/ nucleic …
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Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering
… (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis was to develop a collagen scaffold for the non-viral delivery of the gene encoding for Glial Cell-Derived Neurotrophic Factor (GDNF); hence to …
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Development of collagen scaffolds to address biomechanical design criteria for tendon–to–bone repair
… properties, and are capable of providing mesenchymal stem cells (MSCs) signals in a spatially selective manner. We highlight tradeoffs and synergies in local cellular and mechanical behavior, which give rise to the mechanisms behind observed differences in bulk cellular and biomaterial …
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Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells
<p>Embryonic stem cells (ESCs) are cells that have unlimited capacity for selfrenewal and differentiation. These properties make ESCs a great cell source for application in regenerative medicine. When used for cell therapy, ESC-derived cells could be placed in a wounded area that is likely to be …
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Analysis of soluble high-affinity PD1 variants
… therapeutic to inhibit PD1/PD-L1 signalling. Mesenchymal stem cells (MSCs) offer an alternative drug delivery method for delivering this treatment to the pancreas due to their ability to infiltrate tumours and deliver a therapeutic pay load. In this study soluble PD1 (sPD1) variants were …
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Suspended Micro/Nanofiber Hierarchical Scaffolds for Studying Cell Mechanobiology
… the "inside out" contractile forces of single mesenchymal stem cells (MSCs). The contractile forces (18-320 nano Newton) were found to scale with fiber structural stiffness (2 -100 nano Newton/micrometer). Cells were observed to shed debris on fibers, which were found to exert forces (15-20 …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… umbilical cord derived vascular endothelial cells (HUVEC) or hematopoietic stem cells(HSCs)-mediated formation of microvascular networks in a biocompatible PCL-ßTCP hybrid scaffold in an immuno-compromised nude mouse. The PCL-ßTCP scaffold (30% PCL: 70% ßTCP; 70% porosity) with interconnected …
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Reinforced chitosan-based heart valve scaffold and utility of bone marrow-derived mesenchymal stem cells for cardiovascular tissue engineering
… between the differentiation profile of mesenchymal stem cells (MSCs) and scaffold stiffness. Chitosan is being widely studied for tissue engineering applications due to its biocompatibility and biodegradability. However, its use in load-bearing applications is limited due to moderate to …
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Strategies for improving islet transplantation outcome
… to the inefficient use of valuable donor islets. Mesenchymal Stem Cells (MSCs) secrete a number of soluble trophic factors to affect neighbouring cells, making them excellent candidates for improving the survival of islet cells during culture and after transplantation. The overall aims of the …
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Discovery of novel anti-inflammatory proteins inspired by bone marrow mesenchymal stem cell secretions
Bone marrow mesenchymal stem cells (MSCs) may soon become the first FDA-approved stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may be attributed to molecules secreted by these cells. This thesis will test …
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Roles of growth hormone in liver growth and mesenchymal stem cell myogenic and adipogenic lineage commitment
… determine the effects of GH on the commitment of mesenchymal stem cells (MSCs) to myogenic and adipogenic lineages. In the first study, the GH-deficient lit/lit male mice were injected (s.c.) daily with rbGH or vehicle for two weeks. GH-injected lit/lit mice tended to have a greater liver/body …
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MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that can self-renew and differentiate into cells from the mesodermal cell lineage. Under specific conditions, MSCs are known to transdifferentiate into the neuronal cell lineage. The aim of this study was to investigate if specific …
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