Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 817 for “"Mesenchymal"”.
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Exogenous mesenchymal stromal cells in osteochondral repair
… treatment than are currently available today. Mesenchymal stromal cells (MSCs) are adult-derived, multipotent cells which have immunomodulatory effects, and can differentiate into a variety of cell types, including cartilage progenitor cells, making MSCs a candidate for musculoskeletal cell …
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Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration
… strain that cells would experience in vivo. Mesenchymal stem cells seeded on decellularized tendon scaffolds subject to cyclic mechanical deformation developed strain-dependent alterations in phenotype and measurably improved tissue mechanical properties. The relative tenogenic efficacies of …
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Gene regulatory networks controlling an epithelial-mesenchymal transition
Epithelial-mesenchymal transitions (EMTs) are fundamental and indispensable to embryonic morphogenesis throughout the animal kingdom. At the onset of gastrulation in the sea urchin embryo, micromere-derived primary mesenchyme cells (PMCs) undergo an EMT process to ingress into the blastocoel, and …
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Molecular Control of Tooth Mesenchymal Stem Cell Activation
… the identification and characterisation of a mesenchymal SC (MSC) population has yet to be defined. Aims This study aims to identify the molecular signatures of a novel MSC pool within the lower murine incisor. This work aims to investigate the molecular mechanisms governing the maintenance …
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The mesenchymal regulation of ductal-driven liver regeneration
… of endothelial cells, macrophages and mesenchymal cells to form the functional unit of the tissue. In chronic or severe liver injury, when hepatocyte proliferation is compromised, ductal cells become activated into bipotential progenitors to replace lost epithelium. This process can be …
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Molecular factors influencing epithelial-mesenchymal transition in breast cancer
Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. In a cell model …
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Multiscale Modeling and Quantitative Methods for Mesenchymal Cell Migration.
North Carolina State University Theses Chemical Engineering.
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
… is yet undetermined. We surmised that epithelial-mesenchymal transition (EMT) of hepatocytes might contribute to both hepatocyte dysfunction and liver fibrogenesis. To address this issue, hepatocytes were isolated from normal rat liver and from dimethylnitrosamine (DMN)-induced fibrotic rat …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… signaling. Despite such importance, mesenchymal cells are poorly defined morphologically and molecularly. Their signaling regulation is not well understood, lagging their counterparts in the epithelial, endothelial, and immune lineages. Leveraging single-cell RNA-seq, …
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Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
… efforts to engineer replacement tissues, and mesenchymal stem cells (MSCs), which can undergo chondrogenesis, have emerged as a promising cell source. To date however, the functional properties of MSC-based constructs remain lower than those of the native tissue and of chondrocyte-based …
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Engineered Tracking and Delivery of Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are tissue culture plastic adherent cells that are able to differentiate into multiple cell types, modulate the immune system, and aid in wound repair. These versatile cells are thus being investigated to treat a wide variety of different diseases such as graft vs. …
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Mesenchymal stem cells as trophic mediators of neural differentiation
… adult stem cell-based research. In particular, mesenchymal stem cells (MSCs) present as exciting candidates for potential use in cellular therapies and tissue engineering strategies. MSCs are defined at the functional level in terms of their ability to differentiate into mesodermal derivatives …
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Computational Inferences of Mutations Driving Mesenchymal Differentiation in Glioblastoma
… differentiation of glioblastoma into the mesenchymal subtype, the most aggressive, poorest-prognosis tumors associated with glioblastoma.
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Engineering mesenchymal stem cell sheets on functional polyelectrolyte multilayer substrates
… cultivation of human term placenta-derived mesenchymal stem cells (PD-MSCs). My results revealed that the isolated cells were of maternal origin and possessed very high proliferation and very low mortality rates up to passage twenty. The phenotypic profile of PD-MSC-isolates fulfilled the …
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… of ECM alignment and culture conditions on human mesenchymal stem cell (hMSC) invasion into decellularized tissues. These studies showed that the soluble factors insulin and ascorbic acid promote the invasion of hMSCs into decellularized engineered tissues. We speculate that this is due to an …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic delivery – one that overcomes current limitations. hMSCs are a population of cells with the capability of self-renewal and multilineage differentiation that can be …
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Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential
… drug delivery vehicles. It has been shown that mesenchymal stromal cells (MSCs) derived from the bone marrow (BM) have the ability to specifically migrate throughout a glioma. Upon intratumoral transplantation, they spread within the tumor, along its extensions and toward migrating tumor cells …
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The role of prostate cancer microvesicles in epithelial mesenchymal transition
… foundations of many organs. Epithelial Mesenchymal Transition (EMT) has been linked to malignancy in many carcinomas of epithelial origin. In this study, I look at the role of PC3 (Prostate Cancer cell line) derived MVs in the induction of EMT in PNT2 (normal prostate) cells. Uptake of …
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Mesenchymal stem cell therapy for the treatment of myocardial infarction
Mesenchymal stem cells (MSCs) are currently under investigation as repair agents in the preservation of cardiac function following myocardial infarction (MI). However concerns have emerged regarding the safety of acute intracoronary (IC) MSC delivery specifically related to mortality, …
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