Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Mesangial cells"”.
-
Modulation of TGFβ-Induced PAI -1 Expression by Changes in Actin Polymerization in Human Mesangial Cells
… with activation of normally quiescent glomerular mesangial cells into myofibroblast-like cells. The overall objective of this study is to delineate cellular mechanism/s of myofibroblast-differentiation in disease states. In cultured mesangial cells certain characteristics of myofibroblast …
-
Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… would reduce inflammation via PPAR-γ in cultured mesangial cells, and in murine models of anti-glomerular basement membrane (anti-GBM) glomerulonephritis and Systemic Lupus Erythematosus (SLE). SV40-transformed mouse mesangial cells (MES13) were cultured with pure CLA isomers (c9,t11 or …
-
SREBP-1 and Cell Surface GRP78 are important modulators of TGF-β1 in the progression of diabetic nephropathy
… of diabetes occur in the glomerulus. The mesangial cells are a subpopulation of cells in the glomerulus that are responsible for coordinating responses with other nearby cell types. Transforming growth factor (TGF)-β1 is a cytokine that mesangial cells secrete, and has been identified as a …
-
MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… IL-6, an inflammatory cytokine overproduced by mesangial cells in SLE, contains a potential binding site for miR-let-7a. In order to examine if alterations in miR-let-7a expression can influence inflammatory mediator production in SLE, we isolated mesangial cell miRNAs from 8 and 32- week-old …
-
Subzelluläre Lokalisation des Y-box-Proteins-1 (YB-1) in Mesangialzellen und Charakterisierung der dafür verantwortlichen Proteindomänen
… day YB-1 localizes to the perinuclear region of cells within all glomeruli . In the course of the disease the strongest cytoplasmic YB-1 signal coincided with the peak mesangial cell activation/proliferation between days 4 and 6 and was detected in a mesangial distribution pattern. With …
-
Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
… expressed in vascular smooth muscle cells, renal tubular epithelial cells, podocytes, and mesangial cells. We used highly potent and selective PDE1 inhibitor LY1 to explore systemic hemodynamic and local renal role of PDE1. LY1 reduced systolic and diastolic blood pressure in …
-
Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement
… IgAN and HSN reflected by the common finding of mesangial depositions of C3. Paper I-III investigated whether IgA-binding M proteins are involved in the pathogenesis of IgAN and HSP. In the first study we examined tissue samples from pediatric patients with IgAN and HSP and detected IgA-BR …
-
T-type calcium channels and human mesangial cell proliferation
Aberrant proliferation of human mesangial cells (MC) is a critical step in the pathogenesis of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression …
-
Regulation des DNA-Polymerase-[alpha]-Gens durch den Transkriptionsfaktor YB-1
… DNA binding. Early serum growth response in mesangial cells was accompanied by a nuclear YB-1 shift and nucleocomplex formation at the RE-1. Fine mapping of the DPA RE-1 sequence unravelled a dependency on co-factors for trans-regulation with gene activation in the context of a heterologous …
-
Modelling Human Glomerulosclerosis in vitro
… Glomeruli are composed of glomerular endothelial cells (GECs), podocytes (PODs) and mesangial cells (MCs), and dysregulation in the interaction between these cell types results in glomerulosclerosis. This is characterised by excessive extracellular matrix deposition and cell dysfunction leading to …
-
Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… in this system in high-glucose treated (HG)-mesangial cells (MG) and streptozotocin (STZ)-diabetic rat kidneys. In situ hybridization, RT-PCR, RealTime RT-PCR, and Northern blot were used to study mRNA, and immunohistochemistry and Western blot for protein. IP mRNA was detected in glomeruli, …
-
The role of glycoproteins in glomerular pathophysiology
… and analysis of human glomerular tissue and cells cultured in diabetic-like conditions revealed an altered PGs expression. Paper II focused on the role of PGs in the mesangial matrix in IgAN. One of the main reasons for onset of IgAN is considered to be galactose deficient IgA (gd-IgA) …
-
Identifizierung und Kartierung von nukleären Import- und Exportsignalmotiven innerhalb des Y-box-bindenden Proteins-1 (YB-1)
… In immortalized and proliferationg cells YB-1 is localised in cytoplasm. After stimulation with cytotoxic agents, under hyperthermia or ultraviolet light YB-1 translocates to the nucleus. Accumulation of YB-1 in nuclei of malignant cells is associated with a bad prognosis and higher …
-
Der Einfluss des Y-box-Proteins-1 (YB-1) auf den Notch-vermittelten Signaltransduktionsweg
… an active secretion of Y-box protein-1 (YB-1) by mesangial and inflammatory cells. GFP-tagged YB-1 could be detected in microvesicular structures adjacent to the cell membrane after challenge with PDGF-BB in indirect immunofluorescence. YB-1 is known to fulfill pleiotropic functions in the …
-
Indagini strutturali e quantitative durante lo sviluppo del rene mediante l’utilizzo di elaborazione immagini
… podocytes in urinary space, and of clusters of mesangial cells at the periphery of the glomerulus, was observed. An average podocyte number of 2494 ± 317 and 1546 ± 372 was observed in normal fetuses and beta-thalassemic fetuses (P=0.0082) respectively. In conclusion, a decreasing trend in …
-
Mitogene Effekte extrazellulärer Nukleotide in humanen Mesangialzellen
… auf Wachstumsvorgänge in kultivierten humanen Mesangialzellen. Es konnte gezeigt werden, dass extrazelluläres ATP, UTP und verschiedene weitere Nukleotide zu einer deutlichen Steigerung der DNS-Synthese führen. <br>ATP hat die Rolle eines Komitogens, da ATP alleine nicht wohl aber in …
-
Studies of immunoglobulin receptors and human proximal tubular cells
… hypothesis that an interaction between tubular cells and filtered Ig/immuno complex (Ig/IC) may involve specific cellular receptors, and thus provide a novel mechanism for the initiation of tubular injury and fibrosis. Deposition of Ig and IC is seen in renal diseases such as membranous …