Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Merozoites"”.
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Characterisation of the pre-invasion glycophosphatidylinositol-anchored surface proteins of Plasmodium falciparum merozoites
… disease. During the intraerythrocytic phase, merozoites egress from mature schizonts to invade new uninfected erythrocytes. Glycophosphatidylinositol (GPI) -anchored proteins cover most of the exterior surface of the merozoite prior to invasion, while other GPI-anchored proteins are released …
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New approaches to understanding the interactions between Plasmodium falciparum merozoites and human erythrocytes during invasion
… of the attachment interactions between merozoites and erythrocytes by using optical tweezers to directly manipulate recently expressed P. falciparum merozoites and erythrocytes. This allows the measurement of the strength of attachment, as well as the frequency with which such …
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Static and Microfluidic Live Imaging Studies of Plasmodium falciparum Invasion Phenotypes
… and antibodies targeting ligands on the merozoites were studied and their effects observed using the live-imaging platform. In the results, the functions of ligands on the merozoites demonstrated for the first time distinct and sequential functions of proteins during erythrocyte invasion, …
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A Multi-level Model for a Vector-Borne Organ to Tissue life Cycle Dynamics
… infection should be to reduce the rates at which merozoites and gametocytes invade healthy liver tissue as well as the blood cells. Hence it is recommended that interventions during malaria infection be directed on reducing the pace at which merozoites infect healthy blood cells and the density of …
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Identifying Merozoite Targets of Protective Immunity Against <i>Plasmodium falciparum</i> Malaria
… proteins extracted from <i>P. falciparum</i> merozoites by two-dimensional gel electrophoresis and tested these for reactivity with immunoglobulins from malaria immune adults. Immunoreactive proteins were then identified by mass-spectrometry. In complementary studies, purified <i>P. …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
… have determined that signaling by P. falciparum merozoites and PfGPIs is mediated through A. stephensi protein kinase B (Akt/PKB) and DSOR1 (mitogen activated protein kinase kinase, MEK)/Extracellular signal-regulated protein kinase (ERK), kinases which are associated with the insulin signaling …
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Mathematical modelling of transmission and control of malaria
… of interaction of sporozoites, liver cells, merozoites and red blood cells which cause the symptoms and pathology of the disease is comprehensively studied. We then show how variability of host-parasite immunity is incorporated in the model which are constructed to include liver and blood …
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Defining Molecular Mechanism of Egress in Cryptosporidium
… essential for egress of Cryptosporidium parvum merozoites from host cells. Our results demonstrated that PKG and SUB1 are crucial mediators of merozoite egress, while CDPK5 did not seem to play a role. Cryptosporidiosis affects millions of people worldwide with no licensed vaccine available. …
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Using biophysical tools to explore the erythrocyte preferences of the zoonotic malaria parasite Plasmodium knowlesi
… which may be due to the larger size of merozoites in this species. Next, host cell physical parameters were assessed to investigate whether different experimental conditions have an effect on the biophysical properties, and whether different host cell types have different properties. …
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Cultivation of Eimeria Dispersa in Bobwhite Quail Embryos
… 12.4 micrometers and contained an average of 24 merozoites. Smaller schizonts, probably those of a second generation, were observed between 4 and 10 days after inoculation and contained an average of 12 merozoites. These small schizonts averaged 9.9 by 7.9 micrometers. Mature microgametocytes …
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Equine Protozoal Myeloencephalitis. Preliminary Investigation of Protozoan-Host interactions in the horse
… cells that were infected with S. neurona merozoites. Compared to controls PBMCs co-cultured with S. neurona fragments were the only cells that showed a decreased proliferation (p<0.05). A difference between EPM affected and control horses could not be detected (p>0.05). These results may …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… has also been shown to inhibit invading merozoites and kill blood stages within the first replication cycle (2 days) via an unidentified mechanism, proposed to be independent of delayed death. Thus, we hypothesised that azithromycin could be redeveloped into an antimalarial with two …