Global ETD Search
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Showing 1 to 4 of 4 for “"Merlin-deficient tumours"”.
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
Merlin is a tumour suppressor, and its loss is the major cause of a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… NF2 gene, which codes for the tumour suppressor Merlin, is responsible for the development of all Neurofibromatosis Type 2 (NF2)-related tumours including schwannomas, meningiomas and ependymomas. These tumours can also occur spontaneously in non-NF2 patients. The only available treatments for …
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
Merlin is a tumour suppressor protein that is frequently mutated or downregulated in cancer. Biallelic Merlin inactivation is causative of tumour formation, including schwannoma, meningioma and ependymoma. These tumours can occur sporadically or as part of the genetic condition Neurofibromatosis …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
… caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and …