Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Merlin"”.
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Characterization of the two major merlin isoforms and merlin regulation of YAP
Merlin is the protein encoded by the tumor suppressor gene NF2. Deletion or loss-of-function of NF2 leads to neurofibromatosis type 2, a disease characterized by the formation of multiple benign tumors of the nervous system. In addition to the genetic disorder, loss of merlin expression has been …
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Merlin Mediated Regulation of Hair Follicle Morphogenesis
… Par3 and aPKC as well as the tumor suppressor Merlin, the protein product of the <em>Nf2</em> gene. Merlin plays a pivotal role in the function of the JPC by bridging Par3 to a-catenin and in the absence of Merlin the interaction between Par3 and α-catenin is unable to promote formation of …
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MERLIN : a multiprocessor design for a MicroChannel architecture
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1989.
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PCPs for Arthur-Merlin games and communication protocols
… the power of PCPs in two new settings: Arthur-Merlin games and communication protocols. In the first part of the thesis, we give a 'PCP characterization' of AM analogous to the PCP Theorem for NP. Similar characterizations have been given for higher levels of the Polynomial Hierarchy, and for …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… by loss of the tumour suppressor protein Merlin, caused by bi-allelic mutations of the encoding gene NF2 or by loss of heterozygosity. These tumours can occur either sporadically or as part of the NF2 condition. The majority are slow growing and display benign features, but this benignancy …
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Indoor positioning using modulated echo radio localization instrument (MERLIN)
… thesis discusses a positioning system called MERLIN, which is based on the phase information of CW RF signals. Different range estimation methods are also discussed. Indoor positioning or localization is bound to become a popular feature in the next generation of wireless systems.
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… of an essential role for the Nf2 protein (merlin/schwannomin) in SC tumorigenesis, we demonstrate that merlin loss in SC NPCs results in increased NPC growth and glial differentiation. We also show that Nf2-deficient NPCs exhibit high levels of ErbB2 activation. We further show that …
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Development of Bioluminescent Biosensors Monitoring Activity of the Merlin Tumour Suppressor
… engage signalling to stop proliferation. Merlin, an ERM-like protein, plays a crucial role in CIP and is inactivated in a wide variety of cancers, suggesting that it is a tumour suppressor of general importance in cancer biology. Although the role of Merlin in cancer has been investigated …
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
… the loss of the FERM domain protein Merlin is associated with tumor development and metastasis.Both PTPN14 and Merlin have been shown to localize and possibly regulate adherens junction (AJ) functions. This work sought to determine if PTPN14 is required for the establishment of …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
Merlin is a tumour suppressor, and its loss is the major cause of a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this …
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
… nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal linkers. Similarities between merlin and this family suggest a role for merlin in regulating cytoskeletal function. …
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The Role of Merlin and Apicobasal Polarity In Endometrial Development and Homeostasis
… and organization of epithelial tissues. Merlin couples cell polarity and adhesion through correct localization of the polarity protein Par3 and maturation of apical junctions. Merlin and Par3 are necessary for the development and homeostasis of highly regenerative tissues like the …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. Previous studies have shown …
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Transcriptome activity of human cytomegalovirus (strain Merlin) in fibroblasts, epithelial cells and astrocytes
… of HCMV coding potential was designed. The Merlin strain of HCMV was used for these studies because it has been reported to contain the complete set of ORFs, only one of which (UL128) is mutated. The UL128 gene locus is invariably mutated in HCMV isolates propagated in fibroblasts, and the …
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Layamon's Brut and the March of Wales: Merlin, his Prophecies, and the Lex Marchia
… the most explicit manifestations of this theme: Merlin, his prophecies, and the Law of the March.
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Magic, monsters, and Merlin: an exploration of the fantasy genre in a fifth grade setting
The purposes of this exploratory investigation were to determine how fantasy literature helps children explore, process, and discuss real world issues and topics and what other applications the genre had in the classroom. This study was conducted by implementing a genre study in a fifth grade …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… NF2 gene, which codes for the tumour suppressor Merlin, is responsible for the development of all Neurofibromatosis Type 2 (NF2)-related tumours including schwannomas, meningiomas and ependymomas. These tumours can also occur spontaneously in non-NF2 patients. The only available treatments for …
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
Merlin is a tumour suppressor protein that is frequently mutated or downregulated in cancer. Biallelic Merlin inactivation is causative of tumour formation, including schwannoma, meningioma and ependymoma. These tumours can occur sporadically or as part of the genetic condition Neurofibromatosis …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
… caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and …
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