Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Merkel cell carcinoma (MCC)"”.
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PRMT5 Inhibitors in Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a rare neuroendocrineskin cancer. Treatment options are limited, and they are largely based on MCC’s similarity to other cancers, rather than original research. Many of these treatments have low efficacy and significant side effects, and the overall prognosis remains …
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Pseudovirions in the Study of Papilloma- and Polyomaviruses
… for measuring specific antibodies to HPV and Merkel cell polyomavirus (MCPyV) and iii) perform prospective seroepidemio-logical studies to evaluate whether infection with MCPyV was associated with an increased risk for Merkel cell carcinoma. Site-directed mutagenesis of the surface loops of …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… of as an abnormal population of proliferating cells, is now recognized as a complex system shaped by dynamic interactions across genomic and environmental scales. Advances in research have revealed a multifaceted etiology of tumorigenesis, extending from just hallmark oncogenic mutations to …
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Interactions Between Host Cells And Merkel Cell Polyomavirus In The Context Of Infection And In Merkel Cell Carcinoma
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer often driven by the integration of Merkel cell polyomavirus (MCPyV) into the host genome and the persistent expression of its viral oncoproteins, small tumor (ST) antigen and truncated large tumor (t-LT) antigen. However, …
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Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA
Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with rising global incidence. Merkel cell polyomavirus (MCV) was discovered in 2008 in 80% of MCC samples and since then a causal link between MCV and the majority of MCC cases has been established. microRNAs (miRNA, miR) are a family …