Global ETD Search
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Showing 1 to 4 of 4 for “"Meprin"”.
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Expression and glycosylation of meprin isoforms
Meprin A and meprin B are disulfide-linked, oligomeric metalloendopeptidases in renal brush border membranes. Meprin A contains 90-kDa subunits (α subunits) and is expressed in random-bred and some inbred strains of mice. Meprin B contains subunits of 110 kDa (β subunits) <i>in situ</i>, and the …
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Structure, membrane association, and processing of meprin subunits
Meprins are oligomeric cell-surface metalloproteinases that are expressed at high concentrations in the renal brush border membranes of mice. Meprins consist of two types of subunits, α and β, which are the products of two different genes. The β subunit cDNA was cloned and sequenced from mouse …
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Pathological meprin alpha expression as a driver of inflammatory skin disease
… epidermis. In this context, the metalloprotease meprin a was shown to be upregulated and mislocalized in patients with psoriasis vulgaris and Netherton syndrome. Under healthy conditions, meprin a is expressed by keratinocytes of the stratum basale (SB), suggesting a potential function of meprin …
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The tetrapeptide Ac-SDKP and angiotensin converting enzyme in tuberculous pericarditis and fibrosis
… protein thymosin β4 by the sequential action of meprin-α and prolyl oligopeptidase (POP) and is cleaved by angiotensin-1 converting enzyme (ACE). Importantly, a role of ACE and Ac-SDKP in the regulation of inflammation and fibrosis in multiple tissues and organs has been increasingly described in …