Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Meningococcal disease"”.
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Passive smoking and meningococcal disease
… It is the sixth commonest cause of notified disease with a case fatality rate of 11% for the period 1990 1994. Identification of preventable risk factors is critical as no effective vaccine exists for serogroup B, the most prevalent serogroup in SA. A case control study was undertaken to …
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High throughput measurement of antibody and complement mediated immunity to meningococcal disease
The accepted correlate of protection for meningococcal disease is serum bactericidal activity. The importance of bactericidal activity was established by Goldschneider et al. (1969) who demonstrated an inverse relationship between disease incidence and bactericidal titres of ≥1:4. The importance of …
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The chemoprophylaxis of meningococcal disease in the Cape Town City Council area : an evaluation of programme efficacy
… to household contacts, of patients with meningococcal disease, resulted in protection of those contacts against developing the disease during a 32 week follow up period. The study took the form of a retrospective follow up of 3 350 household contacts of 412 cases notified over a 4-year …
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Petechiae in Children (PiC) study: evaluating potential clinical decision rules for the management of feverish children with non-blanching rashes, including the role of point of care testing for Procalcitonin & Neisseria meningitidis DNA
… guidelines (CPG) for diagnosis of invasive meningococcal disease (MD) in children presenting with fever and non-blanching rash in the UK.<br/><br/>Methods<br/>Data were collected prospectively from 37 UK Emergency Departments (ED) between November2017 and June 2019. Children under 18 years …
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Complement Factor H Related Proteins and their Biological Role During Bacterial Infection
… terminal complement pathway are susceptible to meningococcal disease but further genetic factors that contribute to disease susceptibility are less well understood. A genome wide association study has linked polymorphisms in the Complement Factor H (CFH) locus with meningococcal disease in the …
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Typing and genome comparison of Neisseria meningitidis by DNA-microarrays
… This new clone was associated with severe meningococcal disease and outbreaks world-wide. Therefore, the goal of the second project was to identify genetic differences between ET-15 strains and other ST-11 strains using whole genome microarray technology. Three genes encoding hypothetical …
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Vaccine policy & vaccine politics: an analysis of United States vaccine uptake by state-level school and childcare vaccination mandate policies and state-level election results
… for herd immunity for several infectious diseases in many states. Exemption processes, provisional enrollment policies, and mandate enforcement all vary widely by state. This dissertation aims to characterize the associations between vaccination coverage and both statewide vaccination …
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A molecular epidemiological analysis of meningococcal isolates within Scotland 1972-1998
… and is associated with high case-fatality rates. Meningococcal disease continues to remain a public health issue in Scotland and the rest of Europe. Typing methods are used for epidemiological purposes to investigate outbreaks and the spread of meningococci and to examine the population structure …
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Chemical and conformational studies of bacterial cell surface polysaccharide repeating units
… role in the protection against numerous diseases including meningococcal disease and shigellosis. This study is composed of two parts: a computational section, which investigates the capsular polysaccharide (CPS) repeating unit (RU) conformations of meningococcal Y and W CPS vaccines and …
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Exploring the Population Structure, Recombination Landscape, and Pan-Genome of the Global Neisseria meningitidis Population
… asymptomatic carriage, but those which cause disease are extremely difficult to treat, leading to a high case-fatality rate. As such, there is considerable interest in studying N. meningitidis to understand its spread, what causes development from carriage to invasive disease, and how its …