Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Meningiomas"”.
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Historia natural de los meningiomas incidentales: análisis prospectivo de la tasa de crecimiento de los meningiomas incidentales e implicaciones terapéuticas. Factibilidad y justificación de un programa de cribado poblacional de meningiomas asintomáticos
… de hoy es factible detectar precozmente muchos meningiomas asintomáticos (incidentales), medir su volumen y tasa de crecimiento de forma precisa, seguir a los pacientes de forma prolongada y tomar una decisión terapéutica electiva e informada, en base a su comportamiento biológico y otros …
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Contribución al diagnóstico precoz de los meningiomas intracraneales
Los meningiomas constituyen, dentro de los procesos expansivos intracraneales el grupo más numeroso de tumor benigno, tributario a un tratamiento quirúrgico de extirpación radical. Dada la evolución lenta de este tipo de tumores, se impone un diagnóstico precoz, para detectarlos en las condiciones …
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The identification of biomarker differences between grade I and II meningiomas: Fibulin-2 is a novel biomarker for differentiating grade II from grade I meningiomas
… clinical management, prognosis and follow-up of meningiomas, facilitated by recent advances in meningioma genomics. WHO grade II meningiomas remain a controversial group of CNS tumours to diagnose/treat, compared to the more prevalent and extensively researched grade I tumours. Aim: To identify …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
Background: Meningiomas are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic …
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Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
Although schwannomas and meningiomas are generally benign and slow-growing, the mass effect of either tumour within the nervous system causes life-altering symptoms. Individuals with NF2-related schwannomatosis may develop schwannomas and meningiomas, increasing tumour burden. The primary treatment …
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Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… In order to elucidate the proteomic profiling of meningiomas and identify proteins involved in their pathogenesis, we completed a comparative mass spectrometry analysis of meningioma tissue of all WHO grades, analysing global proteins, phosphoproteins and phosphopeptides. We performed differential …
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Molecular biology and biochemistry of brain tumours
… and its A and B receptors by human gliomas, meningiomas and pituitary tumours. CCK peptides stimulated growth of cultured gliomas and meningiomas as well as in vitro hormone secretion [growth hormone (GH), luteinizing hormone (LH) and follicle stimulating hormone (FSH)] by human pituitary …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… and meningioma. A large group of schwannomas and meningiomas display the inactivation of the NF2 gene. The NF2 gene codes for the tumour suppressor protein Merlin and its loss is associated with a multitude of pro-tumourigenic mechanisms leading to the occurrence of schwannomas and meningiomas. …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
… associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and their relevant signalling pathways. At present the only treatment options for NF2 …
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First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study
… we report the results of the three dogs with meningiomas, all of which were treated with a custom eight element 1 MHz histotripsy transducer at a pulse repetition frequency of 100 Hz and a treatment dosage of 400 pulses/point. Results: Histotripsy was successfully delivered to all dogs, …
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The development and validation of a novel patient-derived 3D meningioma cell culture model
Meningiomas are the most frequent intracranial brain tumours. Current treatment options of surgery and radiotherapy are sometimes insufficient and effective systemic therapies remain unestablished. The development of accurate in vitro systems to model the complexity of meningioma pathology is …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
… 2 (NF2)-related tumours including schwannomas, meningiomas and ependymomas. These tumours can also occur spontaneously in non-NF2 patients. The only available treatments for this group of tumours are surgery and radiosurgery/radiotherapy. Hence, there is an urgent need for new effective …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
Meningiomas and schwannomas are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. …
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An NMR study of human brain tumours: Phosphorus chemical shift imaging in vivo and high resolution proton spectroscopy of biopsy samples.
… tumours ranged from alkaline to neutral, with meningiomas consistently having alkaline pH. A three dimensional localization sequence was written and tested on the Magnetom and used to obtain phosphorus spectra from the brains of normal volunteers. One dimensional $\sp1$H spectra, COSY spectra …
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MRI at 3 T of brain functions and fibre tracts adjacent to intracranial tumors
… edema of gliomas from pure edema of meningiomas and metastases (Paper 4). Results: Strict somatotopic organisation in the primary sensory cortex was shown in the group average; at the subject level the thumb was located laterally, anteriorly and inferiorly to the little finger in 94 % …
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Intensity modulated radiotherapy for skull base meningioma
… tumour (CNS) affecting mostly adults. Skull base meningiomas cause morbidity (and occasionally mortality) by compressing adjacent critical organs, and the aim of treatment is to optimise and preserve CNS function. Radiotherapy is an effective treatment for meningioma, with doses of 50-54Gy in …
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Characterization of the two major merlin isoforms and merlin regulation of YAP
… found in sporadically occurring schwannomas and meningiomas, as well as in mesothelioma. Merlin has two major isoforms that differ in only one exon at the C-terminal. Previous work hypothesized that isoform 11 is unable to suppress growth. In this thesis, I show that both of the major merlin …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
… cortical gradient dispersion. Given that meningiomas exert their deleterious effects by compressing brain tissue whereas gliomas infiltrate the tissue, contrasting both patient groups with healthy controls, gliomas decreased global gradient dispersion whereas meningiomas did not. More …
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