Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Meninges"”.
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MENINGES AS AN OVERLOOKED TARGET FOR GLOBOID CELL LEUKODISTROPHY
… new and important interactions between brain and meninges have been described. Meninges appeared as a highly heterogeneous tissue with trophic, immune and neurogenic properties. Recently it has been identified a neurogenic stem/progenitor cell (NSPC) population present in meninges. In vivo, …
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Intestinal challenges shape the polarisation of dural meninges memory CD4+ T cells
… that protect it, including the three-layered meninges, have been thought to be mostly devoid of immune cells and to interact sparingly with the peripheral immune system. However, recent work has shown that a diverse array of both innate and adaptive immune cells populate distinct niches of the …
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Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy
The meninges have long been accepted as purely structural, protecting the central nervous system (CNS). Similarly, the choroid plexus (CP) was thought to only produce cerebrospinal fluid. Advances have dispelled these limited views, and the meninges and CP are now known as critical sites of immune …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… debatable [3]. Recent data highlighted that meninges, the protective coverings of the brain and spinal cord, are a neurogenic niche. NSCs have been detected in the developing and adult brain and spinal cord meninges both in physiological [4-7] and pathological conditions [8-11]. These NSCs …
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The role of retinoids in the regeneration of the axolotl spinal cord
… In the mammalian central nervous system, the meninges are a source of retinoids for brain tissue. Retinoid production has been described in juvenile Axolotl ependymal cells. Retinoid effects may possess a significant role in the regeneration-permissive interaction of the meninges and ependyma …
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Meningeal Fibrosis in the Axolotl Spinal Cord: Extracellular Matrix and Cellular Responses
… analysis of the ultrastructure of the axolotl meninges, as this has not yet been presented in existing literature, and reveals that the axolotl meninges consist of 3 distinct layers as does mammalian meninges; the dura mater, arachnoid mater, and pia mater. The role of reactive meningeal and …
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ENCEFALOMIELITE VIRAL EQUINA EM DOIS POTROS NO AGRESTE DA PARAIBA
… were non-specific and included congestion of the meninges or neurogenic bladder. Histologically, numerous perivascular cuffs were evidenced, predominantly in the gray matter of the spinal cord, associated with diffuse gliosis, necrosis of neurons with foci of neuronophagia. The meninges were …
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Multiomic Atlasing of Human Mesenchyme Development
… human cranium. Lastly, I profiled the developing meninges, the mesenchyme layers that overlies the brain, across the first and second trimesters, exploring transcriptional links between fibroblast development and meningioma formation. I also studied meninges affected by trisomy 21, and explored …
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Proteomic analysis of genetically stratified grade-I meningioma
… all meningioma mutational subtypes and normal meninges (n=31). Hierarchical clustering analysis showed distinct proteomic profiles of meningioma mutational subtypes and corresponding clusters of differentially expressed proteins. Comparative analysis showed only 10 proteins were commonly …
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Meningeal B cells in central nervous system autoimmunity: Their phenotype and susceptibility to therapeutic depletion
… pathogenesis. B cells can be found invading the meninges around the brain and spinal cord in MS, where they cluster in association with T cells. These meningeal B cells clusters are often adjacent to demyelinating lesions suggesting this may be a site where B cells are exerting their pathogenic …
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Human leptomeninges; inflammatory roles in motor neuron disease, and their potential in gene therapy
The leptomeninges, comprising the inner two layers of the meninges, were traditionally recognised solely for their protective role in the central nervous system (CNS), yet are now understood to be involved in numerous physiological functions including modulation of neurological disorders. …
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Bacterial meningitis in neonates and children South Africa
… meningitis is defined as the inflammation of the meninges. It is caused by various bacteria and the specific aetiology is age dependant. In the neonatal period the causative organisms are: Group B streptococci, Gram - negative bacilli (e.g.: E. coli, Klebsiella spp, Enterobacter spp, Salmonella …
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Cerebro-spinal fever
… spreads, via the blood stream, to the leptomeninges of the brain and cord. • Infection of the meninges may not necessarily result from infection by the meningococcus. In about 2 of cases the initial septicaemia is so severe that the patient succumbs before the lesions of the meninges have …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… sensory innervation to the face, scalp, and meninges. Migraine pain is conveyed to the brain via the trigeminothalamic tract, which relays nociceptive signaling from primary nociceptors to the hypothalamus. Orexins are excitatory, hypothalamic neuropeptides implicated in pain pathways, as …
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Translational Modeling of Non-Invasive Electrical Stimulation
… were considered. The effect of incorporating the meninges was predicted from CAD-based (Computer Aided Design) models before being translated into image-derived head models as an “emulated” CSF conductivity. These predictions were tested in a recently validated database of head models. Multi-scale …
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Heterogeneity, Origins, and Role of Omental Macrophages in Health and Early Tumor Seeding
… we observed CCL19+ fibroblast like cells in the meninges and the cornea layer of the eye. As the central nervous system (CNS) requires precise control of inflammation, we examined CNS-associated macrophages (CAMs) in relation to gut-induced inflammation and various eye injury models to find CAMs …
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Simultaneous cytomegalovirus and herpesvirus meningitis in an adolescent immunocompetent patient a case report
… viral es una afección inflamatoria de las meninges que se manifiesta como neurológica. disfunción con signos clínicos variables, que van desde manifestaciones leves (como dolor de cabeza) hasta convulsiones e hipertensión intracraneal. La presentación clínica puede variar según la edad del …
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Automation and scalability of in vivo neuroscience
… breakthrough due to the lower impedance of the meninges compared to the bone of the skull. This robot allows us access to the brain without damaging the tissue, a critical step in many neuroscience experiments. The second tool is a new type of microscope that can capture high resolution …
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Petroclivale Meningeome : klinischer Verlauf nach operativem Eingriff
… origin in the hyperplastic procedures of the meninges in the arachnoidal cap cells of the pacchionian granulations.They arise preferentially in the middle age and show in the reference to their frequency a summit with patients in the fifth life decade. In addition women are twice as frequently …
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Host and pathogen genetics associated with pneumococcal meningitis
Meningitis is an infection of the meninges, a layer of tissue surrounding the brain. In cases of pneumococcal meningitis (where the bacterium Streptococcus pneumoniae is the causat- ive agent) this causes severe inflammation, requiring intensive care and rapid antibiotic treatment. The contribution …
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