Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Menin"”.
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Developing a novel Drosophila model to study Menin biological function
… MEN1 gene, which encodes the scaffold protein Menin. Menin regulates transcription through interactions with histone deacetylases, histone methyltransferases, and transcription factors, but its molecular function in neuroendocrine tissues remains incompletely understood. Drosophila melanogaster …
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Identification of MEN1 loss-off function as a potential biomarker for immune checkpoint therapy
… CCL5. MEN1 is a TSG encoding the 68kDa protein menin, which has a range of poorly defined functions including an association with homologous-recombination (HR) DNA repair genes, specifically BRCA1, RAD51, and RAD51-AP1. Menin appears to regulate genes through transcriptional regulation but in …
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The role of Men1 in pituitary gland tumourigenesis
… the mouse and not only in the endocrine system. Menin the protein encoded by Men1, shares no homology with any known proteins and contains no recognisable protein domains. Menin is believed to function as a regulator of transcription through binding to several specific transcription factors. …
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Characterising the MLL complex: epigenetic regulation of Hoxa genes
… components of the MLL complex (MLLC, MLLN and menin) as well as HATs that may be associated with the complex (CBP and MOF). Interestingly, the location of these proteins does not always correlate with the marks they deposit. We show that the dual mark H3K9acS10p is present on active Hoxa4 and …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
… therapies for <em>KMT2Ar</em> leukemia such as menin inhibitors, there is an unmet need for sensitive assays to detect these various fusions. Standard next-generation sequencing (NGS) methods cannot accurately detect genetic alterations at low frequencies because of inherent technical errors and …
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Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
… to interact with MLL (mixed lineage leukemia)/menin transcription complex in leukemia cells to facilitate the transcription of cancer-associated genes and leukemic transformation. In order to understand the mechanisms by which LEDGF/p75 contributes to cancer development, we explored its …