Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Memory CD8 T cell"”.
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Antigen-specific memory T cell distribution in non-lymphoid tissue
CD8+ T cells are the main adaptive immune system cell type responding to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) lymph nodes to the lung where they perform their cytolytic function. After …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… critical immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves outcomes. However, it remains unclear how PD-1 pathway …
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Delineating The Roles of IL-12 and IL-23 Produced by Dendritic Cells in Eliciting CD8+ T Cell Resonses Against Listeria Monocytogenes
… IFN-γ production – key for clearance of intracellular pathogens. IL-23 promotes the development of IL-17 producing CD4+ T cells that participate in the control of extracellular pathogens and the induction of autoimmunity. These cytokines modulate T cell activation during primary responses; …
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Identification of protective rickettsial antigens for vaccine development
… to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens and correlates of protective cellular immunity are critical steps towards vaccine development for Rickettsia. However, these are major gaps in this field that are impeding progress …
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… the development and homeostasis of NK and CD8 T cells. IL-15 is produced with its high affinity IL-15Rα and this IL-15Rα/IL-15 complex is shuttled to the cell surface where it is presented in-trans or cleaved into soluble cytokine/receptor complexes. Unfortunately, little is known about the …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
<p>The maintenance and generation of memory CD8 T cells is dependent on the cytokine IL-15. IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what …
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Engineered microneedles for transcutaneous vaccine delivery
… delivery was able to elicit strong functional CD8' T cell and humoral responses matching or exceeding the potency of in vivo electroporation, currently the most promising approach for clinical DNA delivery in humans. Further efforts have explored the use of LbL for encapsulation and delivery of …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
<p>The maintenance and generation of memory CD8 T cells is dependent on the cytokine IL-15. IL-15 is delivered by a novel mechanism termed transpresentation: IL-15 is presented by a cell expressing IL-15Ralpha to the CD8 T cell which responds via IL-2Rbeta/gamma<sub>c</sub>. The identity of what …