Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Membrane-less organelle"”.
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The chronic response to centrosome loss-induced cell cycle exit
The centrosome is a membrane-less organelle which primarily functions as a microtubule organising centre in eukaryotic cells, to allow normal progress through the cell cycle. While centrosome amplification in the absence of p53 is a well-established feature of cancers, more recently centrosome loss …
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Importance of hierarchical interactions in concentrated protein systems
… chemical catalysis, cell metabolism, membrane transport, muscle contraction and more. While many of these interactions can be understood as two-body interactions, other important properties can emerge when large numbers of molecules interact together. In this dissertation, we …
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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions
Nucleoli are nuclear membrane-less organelles that are the sites for ribosome biogenesis and serve as sensors of cellular stress. Weak, multivalent protein-protein interactions and interactions between disordered, low complexity domains (LCDs) and rRNA have been shown to promote liquid-liquid phase …