Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Membrane transporters"”.
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Structural and Functional Study of Multidrug Membrane Transporters
<p>Multidrug membrane transporters (efflux pumps) in both prokaryotes and eukaryotes are responsible for ineffective treatment of a wide variety of diseases, including infections and cancer, underscoring the importance of better understanding of their structures and functions for design of …
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Mechanism and energetics of membrane transporters and channels
… evolved specialized transport proteins called membrane transporters and channels that catalyze exchange of materials across the cell membrane. Membrane trans- porters couple the active transport of their specific substrates against their electrochemical gradient. On the other hand, membrane …
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Chemical selectivity principles of translocation catalysis by membrane transporters
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Insights into dynamics of membrane transporters from computational techniques
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Characterizing ligand and lipid modulation of function in membrane transporters
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… as liver, kidney, brain and intestine expresses membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug …
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Dynamics and Model of the Pore-Forming Protein Lysenin
<p>Membrane transporters are a class of membrane proteins that function to provide a pathway across a cell membrane for the movement of ions and biomolecules. Investigations into the regulatory mechanism of these systems are hindered by their extensive preparation requirements compounded by their …
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COMPLEX FORMATION BY ALPHA-LACTALBUMIN AND POLYSACCHARIDE COPOLYMERS
… potential toxicity due to the disruption of cell membranes and interference with cell membrane transporters. Complexes formed among proteins and polysaccharides, as renewable biopolymers, are drawing attention for their potential application in the food, pharmaceutical, and cosmetic industries due …
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The Effect of Modifying the Higher-Order Structure of Plant High-Affinity Phosphate Transporters
… starvation, including high-affinity phosphate transporters (Phts). Phts are membrane-localized transporters involved in the transport of phosphate and arsenate and have a high capacity for transporting phosphate in areas where phosphate concentrations are low, behaving as the main mechanism of …
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Molecular insights into alternating access mechanism of secondary active transporters from molecular dynamics simulations
Membrane transporters are specialized molecular machinery for selective, regulable, efficient, and more importantly, active transport of diverse chemical species, e.g., nutrients, reaction precursors and products, and chemicals transmitting signals, across the cellular membrane. As a major class of …
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Evolution of Voltage-gated Ion Channels
… (VICs) form a superfamily of energy-independent membrane transporters that facilitate the transfer of charged sodium, calcium, and potassium ions across the cell membrane (Hodgkin & Huxley 1952). The channels contain a selective ion-conducting pore along with several other structural and gating …
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Genetic Analysis of Fic-Mediated BiP AMPylation in Photoreceptors
… of rhabdomeres, closely stacked plasma membrane microvilli that house the proteins of the phototransduction cascade. These phenotypes are replicated in BiP mutants lacking the Thr366 AMPylation site. Strikingly, these degeneration-like phenotypes are reversible: photoreceptors in both …
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Understanding Voltage -Gated Ion Channels via Molecular Archeology
… (VIC) superfamily is one of the oldest groups of membrane transporters. Members of the VIC superfamily are capable of transporting potassium, sodium and calcium ions. The voltage-gated ion channels are well known for their function in excitable tissues of eukaryotic organisms. Eukaryotic members …
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Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM
… from the cell by proteins which are integral membrane transporters. Escherichia coli MDR transporter, MdtM, is a previously uncharacterised, 410 amino acid residues protein from the ubiquitous major facilitator superfamily (MFS). This thesis focuses on the purification and characterisation of …
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Agent Based Modelling of Auxin Transport Canalisation
… plant tissues is mediated by the PIN family of membrane transporters. The exact mechanisms of PIN localisation that facilitate this directional transport are not known. Part of the aim of this work is to test theories of PIN localisation. The development of the agent-based simulations has been …
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Integrative simulation framework for modeling dynamic cellular phenomena in 3D over time
… circadian rhythm, cell cycle, cellular motility, membrane transporters, metabolic pathways, and signal transduction networks. In comparison to 2D methods, the use of a 3D geometry provides considerably more significant data. The possibility of simulating different compartments of a cell with …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
Flavonoids are known to interact with a number of membrane transporters, influencing the rate of intestinal nutrient absorption. The transcriptional effects and consequences of such interactions remained to be fully elucidated. To address this we carried out gene expression microarray analysis on …
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Compensatory renal hypertrophy, mitochondria and redox status
… showed that overexpression of mitochondrial GSH transporters, the dicarboxylate (DIC, Slc25a10) and 2-oxoglutarate (OGC, Slc25a11) carriers, in NRK-52E cells, which are derived from normal rat kidney proximal tubules, exhibited increased mitochondrial GSH uptake, contents of GSH and protection …
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Structures and Mechanisms of Lysosomal Transporters
Lysosomal membrane transporters are indispensable for maintaining lysosomal homeostasis and proper function. Indeed, mutations in these key proteins can lead to debilitating disorders known as lysosomal storage diseases. Cystinosin and Sialin are two such transporters. Both proteins utilize the low …
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… structurally conserved but functionally distinct membrane transporters that function as Ca2+-dependent Cl- channels (CaCCs) or dual functional Ca2+-dependent ion channels and phospholipid scramblases. The TMEM16A and TMEM16B CaCCs conduct Cl- across the membrane and regulate transepithelial fluid …
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