Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 434 for “"Membrane proteins"”.
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Biogenesis of Multipass Membrane Proteins
Roughly one-fourth of all genes code for integral membrane proteins. Most membrane proteins pass back and forth across the lipid bilayer multiple times. Multipass membrane proteins, such as ion channels and receptors, are essential for nearly all transport and communication across the plasma …
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FTIR Difference Spectroscopy Studies on Membrane Proteins
… reactions of individual side chains within proteins, as well as any changes that might occur in the strength of H-bonds any change in the overall protein structure. The method can be applied in a static manner, revealing differences between two defined states of a protein, or can be done in …
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Vesicle-associated Membrane Proteins in Airway Mucin Secretion
… One type of SNARE protein, a Vesicle-Associated Membrane Protein (VAMP), has been shown to regulate exocytosis in multiple cell types.</p> <p>Here, we report that VAMP8 has the highest gene expression among all VAMP isoforms in human airway secretory cells, as revealed by an analysis of a public …
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Multidimensional Solid-State NMR Studies of Membrane Proteins
… to study the structure and dynamics of membrane proteins by using uniformly or extensively isotopically labeled samples. In this work, we first optimized the performance of shaped pulses in magic-angle spinning solid-state NMR experiments by characterizing their frequency profiles and …
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Molecular dynamics studies of membranes and membrane proteins
Properties of phospholipid membrane bilayers and of proteins associating and functioning in the membrane bilayer or at the membrane-water interface are studied by combining molecular dynamics simulations, free energy perturbation theory and continuum electrostatics calculations. Three systems were …
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Rotational motion and organization studies of cell membrane proteins
Cell membranes are dynamic structures with complex organization. The complexity of the cell membrane arises from intrinsic membrane structure, membrane microdomains within the plasma membrane and the membrane cytoskeleton. Plasma membrane receptors are integral membrane proteins with diverse …
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Computational studies of membrane proteins: Structure, function and dynamics
Ion channels are membrane proteins that regulate the flow of ions across the cell membrane. These channels open in response to changes in electrostatic potential across the cell membrane or binding of small molecules to the channels and allow the passage of specific ions through their conduction …
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Computational characterization of membrane proteins at the atomic level
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01
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The role of Moraxella catarrhalis outer membrane proteins in pathogenesis
… component 3 (C3) for which M. catarrhalis outer membrane proteins “ubiquitous surface proteins” (Usp) A1/A2 are responsible. No other pathogenic bacterium is known to bind ACT. The ACT is a serine protease inhibitor playing important part in antiprotease lung protection and anti-inflammatory …
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Accelerated simulations and computer-aided drug design of membrane proteins
Membrane proteins represent ~30% of the proteome and more than 60% of drug targets. They play key roles in physiological functions, such as signal transduction, transport, ion regulation and enzymatic activities. Malfunction of these proteins result in deadly human diseases, such as paralysis, …
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Computational investigation of membrane proteins across species and functional classes
Membrane proteins play central roles in cellular communication, metabolism, and homeostasis, yet experimental characterization of their dynamic interactions with membranes remains highly challenging. In this dissertation, I implement advanced molecular dynamics (MD) simulation workflows to …
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Structure and dynamics of membrane proteins from solid-state NMR
… of the hydrophobic domains for fusion proteins which are involved in membrane fusion between the cell membrane and viral envelope. Although extensive structural studies have been conducted on the soluble ectodomain by crystallography, the structural topologies of the hydrophobic TMD of …
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The roles of clustered membrane proteins in T-cell signaling
… recent experimental results demonstrate that the membrane is a highly organized structure with some membrane proteins inhomogeneously distributed into clusters, which are often called protein islands or protein clusters. The roles of these clustered proteins remain to be established. For my …
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The degradation of membrane proteins from the mammalian endoplasmic reticulum
Membrane glycoproteins of the secretory pathway that cannot adopt their native conformation are targeted for dislocation from the endoplasmic reticulum (ER) membrane for subsequent degradation by the cytosolic proteasome. This thesis investigates factors influencing the catalyzed destruction of MHC …
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Roles of Group B Streptococcal membrane proteins in virulence and protection
… roles in infection, many remain undefined. GBS membrane-associated and secreted proteins are more likely to interact with the host, making these proteins especially important during infection. Importantly, the localization of these proteins also makes them attractive targets for therapeutic …
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A Web Service for Protein Refinement and Refinement of Membrane Proteins
… minimization methods allow us to refine the proteins and obtain native like structures. Previous work shows that some of these methods performed well on soluble proteins. So we extended this work on membrane proteins. Prediction of membrane protein structures is a particularly important, …
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Development of Computational Antibiotic Screening Platform Across Bacterial Outer Membrane Proteins
… of small molecule drugs across bacterial outer membrane proteins, with a goal of accelerating the antibiotic discovery process. We applied all-atom and coarse-grained molecular modeling, enhanced sampling techniques, and a parallel computing environment to maximize the performance. We further …
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Mechanical unfolding of membrane proteins captured with single-molecule AFM techniques
… which serves as a model system for this class of proteins. Mechanical pulling of BetP molecules embedded into the lipid membranes resulted in a step-wise unfolding of the protein and revealed insights into its structural stability. Effect of the lipid environment, N- and C-terminal extensions on …
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Characterisation of the virulence-related, outer-membrane proteins of B. pertussis
… of this study, knowledge of autotransporter proteins was in its infancy and the B. pertussis proteins pertactin, BrkA and tracheal colonisation factor (Tcf) had not been recognised as members of this family. However, the sequence similarity between these Bordetella proteins and a number of …
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