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Showing 1 to 20 of 430 for “"Membrane protein"”.
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Protonation and Membrane Protein Function
… state of a titratable residue embedded in a protein environment can differ from its default value in bulk water at neutral pH. It is thus necessary to correctly evaluate its protonation state in order to generate meaningful reaction models in in-silico experiments. Such evaluations are …
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SNARE specificity in membrane protein traffic
… the discovery of the vesicle trafficking SNARE protein NtSYP121 came the development of the predicted cytosolic domain fragment of the protein. This Sp2 fragment was found in studies to block the responses of guard cell K+ and Cl- channels to ABA. These observations raised questions about the …
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Mechanisms of multipass membrane protein biogenesis
… reagents to improve efficiency. Semi-permeable membranes facilitate autonomy via an outer barrier (plasma membrane) and enclose functional hubs (organelles) to efficiently carry out biological processes. However, cells do not live in isolation and must communicate with neighboring cells, uptake …
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Deconvolution of Membrane Protein-Detergent Complex Interactions
<p>Membrane proteins are important in many biological functions such as cell-cell recognition, transport, and signaling; yet the study of these proteins is stunted due to their excessive aggregation in aqueous solutions. Detergents have been extensively exploited to mitigate this aggregation, and …
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Evolutionary Coupling in Multisubunit Membrane Protein Complexes
… the motifs that mediate interactions between proteins. The strategy for inferring interacting motifs is based on evolutionary correlation, which states that the patterns of mutations in two proteins that interact are correlated across a set of species. This dissertation makes three important …
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Membrane protein biosynthesis at the endoplasmic reticulum
The biosynthesis of integral membrane proteins (IMPs) is an essential cellular process. IMPs comprise roughly 20-30% of the protein coding genes of all organisms, nearly all of which are inserted and assembled at the endoplasmic reticulum (ER). The defining structural feature of IMPs is one or more …
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Atomistic and Coarse-Grained Investigation of Membrane-Protein Interactions
Gaining mechanistic insights into membrane-protein interactions is vital for compre-hending cellular processes and health disorders. In this work, we pursued two sets ofstudies to elucidate such interactions. First, we used atomistic studies to investigate in-creased binding affinity of a …
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THE BIPC MINOR TRANSLOCASE MEMBRANE PROTEIN OF THE BURKHOLDERIA TRANSLOCON
… host immune responses, which injects effector proteins (virulence factors) into a host cell. Burkholderia pseudomallei is a bacterium of high concern to the health of the human population. B. pseudomallei is a human pathogen which is tasteless, odorless, and colorless. It is transmittable …
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Microfluidic platforms for membrane protein crystallization and in situ crystallography
Membrane proteins, biological macromolecules that reside in cellular membranes, play critical roles in many biological process, including signaling, transport, and intercellular communication. The malfunction of membrane proteins has been linked to the initiation or progression of many diseases …
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Computational Approaches For Designing Protein/inhibitor Complexes And Membrane Protein Variants
Drug discovery of small-molecule protein inhibitors is a vast enterprise that involves several scientific disciplines (i.e. genomics, cell biology, x-ray crystallography, chemistry, computer science, statistics), with each discipline focusing on a particular aspect of the process. In this thesis, I …
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Characterization of an outer membrane protein: macromolecular complex of Neisseria gonorrhoeae
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Solid-state NMR studies of membrane proteins and membrane protein complexes
Membrane proteins help control nearly every process in the cell, which is why approximately 50% of pharmaceuticals currently on the market target membrane proteins. Knowledge of structure-function relationships of these proteins could be leveraged to produce more efficient drugs. However, the …
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Microfluidic platforms for the characterization of in meso membrane protein crystallization
Made available in DSpace on 2011-01-21T22:52:44Z (GMT). No. of bitstreams: 2 Perry_Sarah.pdf: 10558894 bytes, checksum: 7b13bc4c87d5aad0fcb056e947e91a74 (MD5) license.txt: 4061 bytes, checksum: 9700a66941381525122ea6b218687cd7 (MD5)
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Role of lipid-protein interactions in modulating the membrane protein function
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Membrane and membrane protein dynamics studied with time-resolved infrared spectroscopy
Proteins are the machinery of the cell, performing functions essential for life. Proteins do not operate in isolation, however. Their function is intimately coupled to their environment; changes in this environment modulate the behavior of the protein. One of the most striking examples of …
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Computational Algorithms for Predicting Membrane Protein Assembly From Angstrom to Micron Scale
… Of the wide range of barriers, the paracellular protein interfaces of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the breakdown of these barriers is associated with serious pathological …
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Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale
… Of the wide range of barriers, the paracellular protein interfaces of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the breakdown of these barriers is associated with serious pathological …
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Characterisation of the PQ-loop repeat membrane protein family in arabidopsis thaliana
… of the PQ-loop repeat family, a novel family of membrane proteins from Arabidopsis thaliana. The family consists of six members (AtPQL1-6) all predicted to contain seven transmembrane segments and two copies of the PQ-loop domain. The repeated PQ-loop domain is a well conserved feature present in …
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Mesophase-based approaches for on-chip membrane protein crystallization and structure determination
Transmembrane proteins traverse the lipid bilayers of cell membranes and play a highly important role in many processes in vivo. Malfunctions of membrane proteins have been shown to cause a variety of disease states, for example, cystic fibrosis, hereditary hearing loss, and hypothyroidism. …
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