Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Membrane permeabilisation"”.
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The effects of altered membrane fatty acid composition on the toxic interactions of heavy metals with Saccharomyces Cerevisiae
The effects of altered membrane fatty acid composition on the toxic interactions of heavy metals with Saccharomyces cerevisiae were examined. Saccharomyces cerevisiae was enriched with the polyunsaturated fatty acids (PUFAs) linoleate (18:2) and linolenate (18:3) by growth in 18:2- or …
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Nutrient-dependent effects of the autophagy-lysosomal inhibitor, Chloroquine, on cell death and lysosomal functionality
… of CQ were potentially triggering lysosome membrane permeabilisation. Indeed, CQ treatment did lead to marked lysosomal stress and enlargement, suggestive of LMP. In contrast, while CQ was still able to enter and deacidify the lysosome in glucose starved cells, it failed to induce …
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A Lab-on-a-chip System for the Standardised Characterisation of Membrane Active Antimicrobials
… of the modes of action of AMPs against membrane models is critical for developing these compounds into novel therapeutics. Throughout my studies, my efforts have been focused on developing microfluidic platforms that can streamline the evaluation of membrane active peptides in a …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
… cell death prior to lysis. Cell death involves membrane permeabilisation, but not by activation of the classical forms of necroptosis, apoptosis nor pyroptosis. Evidence was however found for active caspase-3, gasdermin E-mediated pyroptosis in one cancer cell line. Several vaccinia genes have …
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Antibacterial activity and mode of action of the antimicrobial peptide CPF-MW1 against Escherichia coli ATCC 700928
… to their broad-spectrum antimicrobial activity, membrane lytic activity, rapid killing, and the slow rate of resistance emergence. The AMP, CPF-MW1, was derived from the skin secretions of Xenopus muelleri, a West African clawed frog species, and was identified as a promising AMP worthy of …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… 27-HC uniquely caused lysosomal swelling and membrane permeabilisation, further indicating its particularly disruptive effects on neuronal health. These findings provide mechanistic insight into how oxysterol accumulation contributes to neurodegeneration by simultaneously promoting toxic …
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Biophysical Studies of Protein Assemblies
… apoptosis through control of mitochondrial outer-membrane permeabilisation; a result of BAK and BAX oligomerisation. Through a shared homology motif (termed BH3), the subtle balance of their interactions determines cellular fate at the molecular level. Characterisation of the model under simple …
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Understanding the biochemical properties and physiological function of the protein syncollin
… associated with the luminal leaflet of the ZG membrane; it is also secreted into the pancreatic juice. Syncollin is able to oligomerize, and assemble into doughnut-shaped structures, which might explain its known pore-forming activity. Syncollin appears to be involved in a number of gut-based …