Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Membrane models"”.
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Curvature-dependent functionals: applications to membrane models and geometric flows
L'abstract è presente nell'allegato / the abstract is in the attachment
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Simulation of lipid membrane models at coarse-grained resolution Towards novel methodologies with improved capabilities
… methodologies for simulating biological membranes at coarse-grained (CG) resolution, combining well-established modeling strategies with recent advances in machine learning. It presents an optimized set of lipid representations and parameters for the Martini 3 CG force field (FF), …
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The interaction of antimicrobial peptides with lipopolysaccharide aggregates and model membranes.
Lipopolysaccharides (LPS) released from the outer membrane (OM) of Gram negative bacteria form aggregates which trigger an in ammatory response in humans and can result in severe septic shock. LPS molecules are heterogenic, macroamphiphilic oligosaccharides with a pro-in ammatory activity strictly …
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Multi-Scale Modelling of Host-Microbe Interactions: From Cell Membranes to Multi-Cellular Gut Models
… of conventional 2D in vitro and animal models, which have been the cornerstone for intestinal research, is however limited; while human studies are expensive and preclude individual mechanisms from being investigated. More tailored in vitro models therefore offer an attractive avenue to …
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Quantification of membrane transport rates using optofluidics
The transport of ions and small molecules across membranes is a ubiquitous process in biological systems. Effective studies of membrane transport phenomena require suitable model membrane systems, efficient methods to quantify transport kinetics and a robust theoretical framework to derive …
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Thermodynamic Evidence That Ganglioside-Mediated Insertion Of Botulinum A Into The Cholinergic Nerve Ending May Precede Endocytosis And Acidification: A Langmuir Film Study
… (LB) Trough were adapted to be artificial membrane models for toxin insertion studies. We conclude that LB monolayer studies are a promising candidate for BoNT/A membrane insertion investigation. Botulinum neurotoxin serotype A insertions into the LB monolayers in the presence of BoNT/A low …
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Augmentations vs. Restoration: A computational study of the effects of bacterial sodium channels on cardiac conduction.
… value. This dissertation aims to build models of engineered BacNavs and compare their impact in simulated diseased and healthy cardiac tissue with increases of the endogenous Nav1.5 current to probe mechanisms for therapy.Patch clamp data was analyzed to derive steady-state values and …
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Quantifying passive drug transport across lipid membranes
… one needs quantitative information about the membrane permeability of drugs. In this Thesis, we develop a novel optofluidic permeability assay that allows us to quantify the permeability coefficient of drugs crossing lipid membranes. Lipid vesicles are used as model systems and drug molecules …
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Permeability studies in biomimetic glycosaminoglycan-hydrogel membranes
… charged, fibrous agarose-glycosaminoglycan (GAG) membranes. The work was motivated by current research into the role of the glomerular capillary wall (GCW) in ultrafiltering blood plasma, which is the first step in the processing of blood by the kidney. The GCW is composed of three layers in …
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A Lab-on-a-chip System for the Standardised Characterisation of Membrane Active Antimicrobials
… of the modes of action of AMPs against membrane models is critical for developing these compounds into novel therapeutics. Throughout my studies, my efforts have been focused on developing microfluidic platforms that can streamline the evaluation of membrane active peptides in a …
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The feasibility of reverse osmosis as a water reclamation process with special reference to the rejection of organic compounds
… in the near future provided that a productive membrane life of about three years can be achieved and that membrane fluxes can be maintained at design rates. These findings indicated the need for a pilot plant study to determine the effects of pretreatment and membrane cleaning on flux levels …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
… heterogeneous interactions, including with lipid membranes. Lipids have been found in NFTs, anionic lipid vesicles induced aggregation of the microtubule binding domain of tau, and other protein aggregates induced ion permeability in cells. This evidence prompted our investigation of ta's …
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Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
… believed that the selectivity for bacteria cell membranes over host cells and the potency between different bacteria strains is derived from the ability of the AMPs to exploit the differences in chemical composition of various organism's membranes. The hypothesis guiding this research states: The …
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COMPUTATIONAL MODELING OF BACTERIAL OUTER MEMBRANES AND DEVELOPMENT OF HIGH-THROUGHPUT SCREENING PLATFORM FOR ANTIBIOTICS
… readily due to their unique highly charged outer membrane. Structurally, the Gram-negative bacteria is highly asymmetric bilayer that comprises of an inner leaflet of phospholipids and an outer leaflet of lipopolysaccharides. Embedded in the bilayer are outer membrane proteins (OMPs) that form …
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Multiscale modelling of woven and knitted fabric membranes
Light-weight fabric membranes have gained increasing popularity over the past years due to their tailorable structural and material performances. These tailorable properties include stretch forming and deep drawing formability that exhibits excellent stretchability and drapeability properties of …
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Self-assembly of nanostructured amphiphiles onto surfaces: Design principles for substrate mediated biomedical applications
… main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid multi-layered films on solid supports only recently begun drawing scientists’ attention for their potentials to catalyze many substrate-mediated biomedical applications. These applications include …
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MODULATION AND INTERACTIONS OF CHARGED BIOMIMETIC MEMBRANES WITH BIVALENT IONS
<p>The biological membrane of an eukaryotic cell is a two-dimensional structure of mostly phospholipids with embedded proteins. This two-dimensional structure plays many key roles in the life of a cell. Transmembrane proteins, for example, play the role of a gate for different ions (such as Ca2+). …
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Host Defence Peptides (HDPs): investigating the structure-to-function relationship through bio-physical techniques
During last decades, more and more microorganisms resistant to conventional antibiotics were isolated while few new antimicrobial drugs were developed. The urgent need for novel efficient antibiotics led a great attention on cationic host defense peptides (HDP) since their discovery in 1980s. The …
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STRUCTURAL INVESTIGATION OF EXTRACELLULAR VESICLES AND THEIR INTERACTION WITH BIOMIMETIC INTERFACES
… extracellular vesicles (EVs), the nanosized membrane bound vesicles, secreted by all kinds of cells to deliver a physiological cargo and their influence on the cell-mediated communication has been rising as a hot topic. Different EVs, have different characteristics and activities, so their …
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Critical Quality Attributes of Topical Semi-solid Dosage Forms: Solvent Activity
… diffusion cells across cellulose and silicone membrane (porous-hydrophilic and non-porous-hydrophobic membrane models, respectively) in order to elucidate the effects of water activity on drug release from formulation vehicles. Caffeine flux was found to decrease with decreasing water activity …
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