Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Membrane fluidity"”.
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Inducción térmica del inicio de la replicación cromosómica en Escherichia coli
… thermodynamic alteration of oriC structure or of membrane fluidity could explain the observed HIR.
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… we explored aberrant apoptosis pathways and cell membrane fluidity as novel therapeutic targets.</p> <p>We first identified an effective therapeutic strategy against TNBC and IBC by pro-apoptotic protein NOXA-mediated inhibition of the anti-apoptotic protein MCL1 following inhibition of histone …
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Investigating the effect of a Mycobacterium tuberculosis inhA promoter mutation in cell envelope composition and morphology
… and organisation of M.tb cell wall we assessed membrane fluidity using DPH, a membrane fluorescent probe. In parallel, a preliminary investigation of cell wall integrity using propidium iodide was performed. Finally, to determine the influence of IPM on MA, two extraction protocols were compared …
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Mechanism of Action of Pentobarbital Induced Attenuation of Vascular Smooth Muscle Contraction
… increases ECI. PB is also thought to increase fluidity of both artificial and nerve membranes. We examined ECI as a function of altered membrane fluidity in A<sub>7r5</sub> (embryonic rat aortic) VSM cells. Fluidity was increased by treatment with docosahexaenoic acid (22:6), a polyunsaturated …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… techniques: specific growth rate, membrane fluidity, membrane leakage, membrane lipid analysis, hydrophobicity, carboxylic acid production, transcriptome analysis, intracellular pH, γ-amino butyric acid determination, proton motive force simulation, genome reverse engineering, and …
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Effects of environmental temperature on members of the mucorales
… groups. Subsequent investigations of plasma membrane permeability suggested that plasma membrane structure and function may be significant in establishing both the upper and lower growth temperature limits characteristic of psychrophiles, mesophiles and thermophiles. Analysis of the plasma …
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Influence of protein and lipid domains on the structure, fluidity and phase behavior of lipid bilayer membranes
… bilayer forms the basic structure of the cell membrane, which is a heterogeneous matrix of proteins and lipids that provides a barrier between the interior of a cell and its outside environment. Protein and lipid domains in cell membranes can facilitate receptor localization, stabilize …
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FATTY ACIDS IN PHYSIOLOGY AND PATHOLOGY: FOCUS ON ALPHA-LINOLENIC ACID (ALA) AND PUFAS
… essential nutrients involved in modulating cell membrane fluidity, intracellular signaling, and gene regulation, as well as serving as precursors to bioactive lipid mediators such as eicosanoids and prostaglandins. Following a general overview of fatty acid classification, structure, metabolism, …
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Biochemical changes associated with embryonic and larval development in the American lobster Homarus americanus Milne Edwards
… sterols were primarily associated with cellular membranes. During tissue catabolism (starvation), P. ethanolamine was catabolized but sterol was conserved. On average, P. ethanolamine fatty acids were the most unsaturated, followed by the fatty acids of P. choline and then triacylglycerol. The …
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The effects of mechanical forces on lymphocyte adhesion and migration
… caused by differences in integrin expression, membrane fluidity or cell cycle regulation. Lastly, we examined the effects of protein kinase C and protein tyrosine kinase on lymphocyte adhesion and migration.
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Influence of plant growth regulators on turfgrass polar lipid composition, tolerance to drought and salinity stresses, and nutrient efficiency
… which are major factors in changing cell membrane fluidity and permeability. The PGR-induced alteration of cell membrane lipid composition could be an adaptive process to protect plant membrane function under drought and salinity stresses. However, the metabolic effects of PPC and FSE may …
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Investigating proteins that influence membrane-associated germination processes in Bacillus subtilis spores
… for efficient spore germination and influences membrane fluidity in dormant spores. All the members of the lipoprotein family serve the same function, as each can fulfill the role of another. In vivo cross-linking was used to characterize protein-protein interactions found on the inner spore …
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Comparative analysis of the role of redox active molecules on bioenergetically active membranes
… peroxidation, protein inhibition, changes in membrane fluidity and potential. DNA damage and cell death. The effects that vanadium has is highly dependent on the speciation and state that they exist in. this can impact the system that is being affected and the outcome. Species such as …
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Studies of CD36 interacting with fatty acids, oxidized low-density lipoprotein, and the cellular plasma membrane
The glycoprotein CD36 is expressed in the plasma membrane (PM) of many cell types that surround or contact arteries, including macrophages, myocytes, and endothelial cells. CD36 binds oxidized low density lipoprotein (oxLDL), which promotes atherosclerosis, and fatty acids (FA), which promotes …
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The Influence of Incorporated Cholesterol Auto-Oxides Upon The Permeability and Fluidity of Multilamellar Vesicles (Oxidized Sterols)
… molecule had an effect on the permeability and fluidity of these model membrane systems. An additional goal was to determine whether or not the polar substituent groups altered the orientation of the sterol molecule within the membrane bilayer. Using cholesterol incorporation into multilamellar …
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Mechanisms Involved in Human Thermogenesis
… in neuroprotection, with a role in maintaining membrane fluidity. These studies broaden our knowledge of human energy homeostasis. They provide evidence for the role of GPR10 in human energy homeostasis, and a rationale for the targeting of GPR10-mediated signalling pharmacologically, and …
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Investigations of the Role of Triglycerides in Synthetic Colloidal Systems
… earth, the cell, is delimited by the biological membrane. Biological membranes, broadly speaking, are composed of phospholipid (PL) bilayers and a variety of membrane-associated proteins that assist in the maintenance of cells and their organisms. Since the 1990's, the components of synthetic …
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P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
The ABC transporter P-glycoprotein (Pgp) and membrane permeability are determinant factors for absorption and disposition of xenobiotics. These studies investigated the effects of potential modulators of Pgp and/or membrane function on the disposition, bioavailability and bioaccumulation of …
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The use of lipid profiles from immobilised selenastrum capricornutum in the biological surveillance of freshwaters
… of cells as a consequence of alterations in membrane fluidity and membrane disruption. The Cu uptake from solution was greater in immobilised cells than free cells, thus gel confinement did not confer any protection to cells. The characteristic and significant changes within the lipid …
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In vitro studies on the cellular mechanisms of resistance to cytotoxic compounds with special reference to multidrug resistance and cancer chemotherapy
… and stationary phase cell density. The plasma membrane fluidity and total protein content of the cell lines were not significantly different. Immunoprecipitation revealed the presence of P-glycoprotein in the EMT-6/R cell line but not in any detectable amounts in the parent cell line. No …
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