Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Membrane damage"”.
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Dynamics of membrane damage to skeletal muscle cells at supraphysiological temperatures and the role of poloxamer 188 in minimizing membrane injury
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.
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Insulin based inhibitors of human islet amyloid polypeptide (hIAPP) and their effect on hIAPP- mediated membrane damage in type 2 diabetes mellitus
… pancreatic beta cells, that plays a role in the damage of cell membranes by forming amyloid fibrils in Type 2 diabetes. Insulin has been found to inhibit hIAPP (Human Islet Amyloid Polypeptide) aggregation. The HLVEALYLVC amino acid region of insulin contacts hIAPP near the N-terminus. Truncated …
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A Microfluidic Device for Transfection of Mammalian Cells Using Adjustable Shear Stress
… by applying shear stress to cause temporary membrane damage. The advantage of this physical method of transfection is the possibility of incorporating large molecules that cannot be inserted with more traditional chemical transfection methods, while avoiding the large fall in viability seen …
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Onion (Allium cepa L.) seed aging and plant regeneration in vitro
… dehydration and fungal infection may lead to membrane damage. Aged seeds had a high electrolyte leakage and encountered hydration stress which reduced seed germination and seedling vigor.
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The Synthesis, Separation, and Identification of Methyl Arachidonate Hydroperoxide Positional Isomers and Their Effect as Components of Large Unilamellar Vesicles on Vesicle Calcium Ion Uptake
… and arachidonic acids have been associated with membrane damage.
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F₂-isoprostanes study after exposure to selected nanoparticles by liquid chromatography/tandem mass spectrometry and investigation of nanoparticles on the cytotoxicity effect of arsenic in vitro
… This implied that nanoparticles caused cell membrane damage due to lipid peroxidation. After this work, the isomers of F₂-isoprostanes were investigated further. The purpose of the second part dissertation is to study the patterns of F₂-isoprostanes isomers corresponding to nanopartilce …
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Tools for improving and understanding microbial performance in biorenewable applications
… focus on improving the robustness of biological membranes. Microorganism growth and production can be inhibited by both biomass feedstocks and the biorenewable products. One component of that inhibition is due to membrane damage. There is still little known about the biomolecular effects of …
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Insulin based inhibitors of human islet amyloid polypeptide (hIAPP) and their effect on aggregation of hIAPP in the treatment of type II diabetes
… results indicate that they actually enhance membrane damage, as measured by the increased leakage of carboxyfluoroscein dye from membrane model vesicles.</p>
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The Role of Membrane Lipid Composition on Skeletal Muscle Damage in the Rodent Model of Duchenne Muscular Dystrophy
… muscle disease, which leads to alterations in membrane phospholipid fatty acid (FA) composition and skeletal muscle damage. Increased membrane saturated FA in muscular dystrophy may suggest its association with increased susceptibility (as being the cause or consequence) to muscle damage. It …
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Comparative Impacts of Irradiation on Antioxidant Compounds of Scalded and Non-scalded Skin of Granny Smith Apples
… systems mitigating the extent of this damage. This study evaluated the effects of gamma, X-ray, and electron beam irradiation on antioxidants – ascorbic acid, total phenolics, α-tocopherol, carotenoids, chlorophyll, and campesterol – in scalded and non-scalded apple peel tissue. Apples …
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Application of intense pulsed light for surface sterilization and food quality improvement
… E. coli population is more susceptible to membrane damage when compared to other microorganisms. This suggests that photoinactivation involves effects on sensitive sites (genetic material) within the treated organisms which do not lead to significant changes in the microorganism morphology. …
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Temporal patterns of metal ion and nanoparticle uptake by Lolium perenne in hydroponic systems in the presence of amendments ethylene diamine disuccinic acid (EDDS) and gibberellic acid
… breaks in the casparian strip, or through damaged physiological barriers. Plant hormones can also affect metal uptake as they regulate plant development and some hormones can activate plant defence mechanisms under adverse environmental conditions, thus alleviating stress. Presence of …
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Exercise induced pain and damage in human skeletal muscle
… to investigate their effects on muscle pain and damage in normal subjects. Damage was assessed by studying changes in isometric force generation, muscle enzyme loss, morphological changes and the patterns of radioisotope uptake. Delayed onset muscle pain occurred after eccentric but not …
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New methods for cryopreserving rooster spermatozoa
Rooster spermatozoa sustain permanent membrane damage during cooling, thawing and dilution due to inappropriate changes during the phase transition and osmotic intolerance. Glycerol is a common cryoprotectant used to protect cells during freezing, but its relatively large molecular weight and …
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Anti-asthmatic and anti-cough activities of the essential oil Of Eucalyptus Grandis W. Hill Ex Maiden
… 0.625 mg/ml to >5 mg/ml. The LDH release assay (membrane damage) revealed bacterial membrane damage ranging from 1% to 11% in comparison with the standard tritonX-100. Accumulation of rhodamine 6G in bacterial cells, which was used to determine the activity of the essential oils as drug efflux …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… techniques: specific growth rate, membrane fluidity, membrane leakage, membrane lipid analysis, hydrophobicity, carboxylic acid production, transcriptome analysis, intracellular pH, γ-amino butyric acid determination, proton motive force simulation, genome reverse engineering, and …
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Sphingomyelin as a danger signal in cell-autonomous immunity
… on the extracellular leaflet of the plasma membrane under homeostatic conditions, become hidden inside bacteria-containing vacuoles (BCVs) during bacterial entry into the cell. Upon BCV rupture, glycans become exposed to the cytosol where they act as a danger signal and are detected by the …
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Silicon nanopore patch clamp device for measuring single ion channel activity
… seal between a glass micropipette and a cell membrane. This transformative method allows low noise recording of current arising from single ion channels or from an entire cell and has no equivalent in experimental neuroscience. However, the consistent formation and maintenance of a high …
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Cellular determinants of reovirus entry and infection
… that ISVPs can directly penetrate the plasma membrane since these particles can cause membrane damage and hemolysis at high multiplicities of infection. We used a combination of techniques to show that these particles can use endocytosis to enter and productively infect host cells. We found …
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Characterization of beneficial mutations in unsaturated fatty acid biosynthesis that are recurrent dead-ends in a long-term evolution experiment with Escherichia coli
… fatty acid synthesis and also found signs that membrane damage responses were activated. It is possible that fabR mutants are near a stability cliff that makes them unable to access otherwise beneficial further mutations. Ultimately, this work will elucidate how interactions between the …
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