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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Membrane composition"”.
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Modification of Milk Fat Globule Membrane Composition by Selective Adsorption and Its Effect in Functionality
Treatment of dairy creams with the silicate adsorbents showed that differences in functional properties of the creams could be obtained by selective interaction of the silicates with some of the cream components. The modified creams were successfully used in the manufacture of low-fat dairy spreads …
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A thermodynamic study of the effects of membrane composition on the binding affinity of annexin a5.
… thus, they are a model system for peripheral membrane binding proteins. One member, annexin a5, binds membranes enriched in the acidic phospholipid, phosphatidylserine, and calcium ion. We find by Isothermal Titration Calorimetry (ITC) that annexin a5 binds calcium ions with much higher …
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Evidence for the role of delta-6-desaturase in the development of cardiometabolic disease
… general hypothesis that changes in fatty acid membrane composition found to be associated with cardiometabolic disease are attributed to delta-6-desaturase activity and contribute to the development of disease. The specific aims of each experimental series were to: 1) Determine whether …
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Engineering Small Extracellular Vesicle-Derived Vehicles Carrying Optimized microRNA for Cardiac Repair after Myocardial Infarction
… but these have high toxicity, compromised membranes and poor uptake. Therefore, there is a need for cell-free vehicles with sEV-like membrane and uptake, which allow delivery of customized cargo. To address these needs, the aim of this study was (1) to develop an sEV-like vehicle (ELV) with …
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Identifying Modulators of the Development of Acute Functional Tolerance to Ethanol in Caenorhabditis elegans.
… response. We also examined the role of lipid membrane composition in the response to ethanol. Identification of modulators that are responsible for alcohol-induced responses will provide a greater understanding of the mechanisms that cause alcohol-related diseases.
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The Role of Membrane Lipid Composition on Skeletal Muscle Damage in the Rodent Model of Duchenne Muscular Dystrophy
… muscle disease, which leads to alterations in membrane phospholipid fatty acid (FA) composition and skeletal muscle damage. Increased membrane saturated FA in muscular dystrophy may suggest its association with increased susceptibility (as being the cause or consequence) to muscle damage. It …
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Blood coagulation reactions on nanoscale membrane surfaces
… coagulation requires the assembly of several membrane-bound protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these procoagulant proteins, but can also affect their function. Increased exposure of …
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Transcriptomic and proteomic analysis of lycopene-overproducing Escherichia coli strains
… redox balance (pntB); growth rate reduction; and membrane composition. In the pre-engineered background strain, deleting pntB (~20-25%) and ydeO (~30%) each led to moderately increased production; overexpressing wrbA led to 50-100% more production at 8 hours and 5-15% more production at later time …
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Interactions of functionalized vesicles in the presence of Europium (III) Chloride
… di- and trivalent ions were used to induce inter-membrane interactions. Measurements performed with isothermal titration calorimetry (ITC) revealed that interaction between EuCl3 and ß-diketone receptors was characterized by a molar enthalpy 126 ± 5 kcal/mole and an equilibrium binding constant 26 …
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Oxygen Transport Membrane Reactors for Oxy-Fuel Combustion and Carbon Capture Purposes
<p>This thesis investigates oxygen transport membrane reactors (OTMs) for the application of oxy-fuel combustion. This is done by evaluating the material properties and oxygen permeability of different OTM compositions subjected to a variety of operating conditions. The scope of this work consists …
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Nitrate Selective Electrodes Containing Immobilised Ion Exchangers
… f nitrate has been producedu sing polymeric membranesc ontainingi mmobilisedq uaternarya mmonium saltsa s the ion exchanger.T he useo f the conventionasl olventc astingt echniqueg ave rise to a relatively low cross-link density, two sided response and poor thickness control. The developmenot …
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The conserved dedA family of E. coli membrane proteins: genetic and topological analysis
… conditional growth defects and alterations in membrane composition. A temperature-sensitive mutant named Lud135 was isolated with mutations in two related, nonessential genes: yghB and yqjA. yghB harbors a single missense mutation (G203D) and yqjA contains a nonsense mutation (W92TGA) in …
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Probing the conformational dynamics of amyloid oligomers in biologically relevant microenvironments
… cytotoxic species, which permeabilize plasma membranes and induce Ca2+ dysregulation. In the 25 years since the introduction of the oligomer hypothesis, the phenomenon remains poorly understood. While some amyloids are cytotoxic, others do not spontaneously aggregate in ways related to disease …
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Identification and characterization of components of rab-6-mediated trafficking in caenorhabditus elegans
Membrane trafficking in neurons is an important mechanism used to regulate signaling. Controlling the abundance of AMPA-type receptors at the synapse is important for synaptic plasticity and influences processes involved in learning, memory formation, and motor control (Greger and Esteban, 2007; …
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Uncovering Structure-Property Relations in Biomimetic Lipid Membranes with Molecular Additives
… lipid bilayer, the fundamental structure of cell membranes, exemplifies a highly adaptable molecular assembly with characteristics that have been fine-tuned through evolution to meet the diverse functional needs of cells. These bilayers must strike a delicate balance: they need to be sufficiently …
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The effects of exogenous application of abscisic acid and α,α'-dipyridyl on cold acclimation and physical characteristics of Pisum sativum 'Alaska' seedlings
Cold acclimation entails changes in membrane composition, osmotic adjustment, alterations in the cell wall-plasma membrane interface, sugar deposition, and changes in cell wall proteins. There is evidence that a rigid cell wall may be necessary for cold acclimation. Difficulties arise in studying …
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Mechanistic Insights into the Role of Munc13 in Synaptic Vesicle Docking, Priming, and Fusion
… fusion of synaptic vesicles with the presynaptic membrane. These fusion events are tightly regulated by the influx of Ca2+, which is sensed by the complex protein machinery at the axon terminal. In order for these Ca2+-mediated fusion events to occur in the correct time and place, protein machines …
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Modified Hydrogel Matrices in Fibre Optic Sensors
… to a lack of understanding of polymer support or membrane properties and hence failure to optimise membranes chosen for specific sensor applications. Hydrogels can be described as polymers which swell in water. In addition to this, the presence of water in the polymer matrix offers some control of …
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Molecular Dynamics Studies of the *Gating Mechanism of a Mechanosensitive Channel
Mechanosensitive channels are integral membrane proteins that gate in response to tension in the membrane. One such channel, MscL, poses an especially interesting challenge to modelers both because the channel is activated by membrane tension alone, and because the transition to the open state …
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Medical Engineering Across Length Scales Using Structural and Analytical Biomaterial Nanotechnology
… a clathrin-mimetic DNA triskelion via membrane-anchored linker strands. The DNA coating was found to enhance the mechanical stiffness of the composite structures which was tunable by modifying the rigidity of the DNA triskelion. Decelerated dye leakage from the inside of liposomes upon …
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