Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Membrane bilayers"”.
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An Examination of Oxysterol Effects on Membrane Bilayers Using Molecular Dynamics Simulations
… focuses on understanding the role of biological membranes in cellular processes. I am particularly interested in how small molecules perturb membrane structure and regulate membrane function. Membranes are primarily responsible for segregating different compartments of biological cells from each …
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NMR investigations of blood coagulation: Conformational changes of membrane bilayers and proteins in blood coagulation
A multitude of biological processes involve membranes and their associated membrane proteins. The interactions of these biological molecules lead to perturbations in their structure and dynamics. Understanding the variations in the constitution of these molecules as the result of functional …
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Utilizing small molecule probes to study the regulation of proteins by specific phospholipids in membrane bilayers
DSpace SAF Submission Ingestion Package generated from Vireo submission #14494 on 2020-02-28 at 17:12:54
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Molecular dynamics studies of membranes and membrane proteins
Properties of phospholipid membrane bilayers and of proteins associating and functioning in the membrane bilayer or at the membrane-water interface are studied by combining molecular dynamics simulations, free energy perturbation theory and continuum electrostatics calculations. Three systems were …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
… tau aggregates more efficiently disrupt membrane bilayers and induce Toll-like receptor 4-dependent responses in human macrophages. We also found that non-phosphorylated tau could polymerize into amorphous, cytotoxic aggregates when induced by hyperphosphorylated tau in situ, having …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
Cytochrome P450 2J2 (CYP2J2) is membrane bound enzyme that is highly expressed in the cardiovascular system and brain where it mediates the metabolism of polyunsaturated fatty acids into oxygenated bioactive metabolites. This enzyme is most well-known for the conversion of arachidonic acid into …
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Structure and Application of Photosensitive Self-assembled Pseudoisocyanine J-aggregates on Membrane Surfaces
… on planar bilayer templates, and on the membranes of living cells. Pseudoisocyanine J-aggregates were found to form on top of the heterogeneous lipid domains in a phospholipid bilayer. This behaviour is limited to a few headgroup chemistries and lateral packing motifs, allowing one to …
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The membrane lipid composition regulates talin mediated integrin activation
Integrins are a family of transmembrane receptors that mediate cell-cell and cell-extra cellular matrix (ECM) interaction and signaling. Inside-out activation of integrin receptors often requires the binding of the cytoplasmic domain of the subunits by talin. This interaction leads to separation of …
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Fatty acid synthase is a major polypeptide constituent of cytosolic lipoprotein and is associated with components of the milk lipid secretory pathway
… lipid droplets, and the milk lipid globule membrane (MLGM). A similar complex to LDFAS was isolated from ER from liver and mammary gland homogenates following incubation in buffer containing ATP. Polypeptide constituents of this complex had similar electrophoretic patterns to LDFAS, but …