Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Membrane Potentials"”.
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Membrane potentials in the isolated small intestine of the bullfrog
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Bilayer Network Modeling
… a modeling scheme that is developed to model the membrane potentials and ion currents through a bilayer network system. The modeling platform builds off of work performed by Hodgkin and Huxley in modeling cell membrane potentials and ion currents with electrical circuits. This modeling platform is …
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ELECTROPHYSIOLOGICAL STUDIES ON ULMUS AMERICANA
<p>Although membrane potentials have been measured in algal cells and in large cells of some higher plants, this investigation is the first to include such measurements in mesophyll cells of elm (Ulmus americana) leaves. The inquiry entailed the development of the technique for measuring elm leaf …
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A mathematical model of the airway epithelium: Computational studies of ion and water balance
… apical, basolateral, and transepithelial membrane potentials; cell and apical volumes. Membrane transport processes included apical passive diffusion of sodium and chloride, basolateral passive diffusion of potassium, basolateral sodium-potassium active transport, basolateral …
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Mechanisms of methylenedianiline toxicity to rat biliary epithelial cells
… assessing cellular ATP levels and mitochondrial membrane potentials. 5). Determine if BEC glucose uptake is altered following exposure to analog, alpha-methyl-D-glucopyranoside. Numerous in vivo and in vitro methods were combined to develop a model of polarized rat BEC monolayers that were …
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A feedback analysis of outer hair cell dynamics
… mammals. Excitatory displacement of the basilar membrane causes depolarization of OHC membrane potentials which results in contraction. The motor protein prestin is driven by receptor potentials. However, low-pass filtering by the plasma membrane should severely attenuate the receptor potential …
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Investigating the effects of impermeant anions on the electrical and computational properties on neurons
… ions that are unable to traverse the cell membrane. Impermeant anion quantities and their average charge vary with metabolism as well as protein and nucleic acid synthesis/turnover.The effect of spatiotemporal changes to impermeant anions on neurons is poorly understood. Using a …
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Technologya nd Protocolsf or Translational Researchin ElectricalS timulation
… leading to subthreshold changes in neuron membrane potentials. Neuromodulation of the cortex using direct current (DC) stimulation may be a viable treatment for neurological disorders, enhancing cognitive function as well as facilitating neural plasticity. Theoretically, tDCS can employ …
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Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion
… and peaked at +20 mV. At physiological membrane potentials (≤-20 mV), the maximum rate of release was ~4 granules/s. Exocytosis in β-cell depends on Ca2+-influx via L-type Ca2+-channels, whereas N-type Ca2+-channels are important in α-cells. δ-cell exocytosis exhibits a post-stimulation …
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Potential-Dependent-Adsorption and Reorientation Responses Associated With a Phospholipid Monolayer at the Water /Dichloroethane Interface
… species over the full range of trans-membrane potentials studied, 0.14 V ≤ Ew-E o ≤ 0.47 V. At the positive end of this range, Ew-Eo > 0.32 V, the affinity of DLPC for the interface is diminished and I becomes a more effective competitor for interfacial sites. The steady state …
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Voltage Sensing Mechanism in the Voltage-gated and Proton (H+)-selective Ion Channel Hv1
… in Hv1 channels is controlled by changes in membrane potential and the transmembrane pH gradient (ΔpH). The mechanism by which changes in ΔpH affect the apparent voltage dependence of GAQ activation is not understood. In order to measure voltage sensor (VS) activation in Hv1, we mutated a …
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Ion transport in the ileum of the desert locust Schistocerca gregaria, forskal
… were used to measure apical and basolateral membrane potentials. Brief transepithelial current pulses (13.3 μA) and ion substitutions permitted the estimation of specific ion conductances. In nonstimualted ilea, Vt was slightly positive (to the lumen side) and the inside of the cell was …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… effects depolarized or hyperpolarized the cell membrane potential, respectively. Further electrophysiological experiments were performed on native isolated\r\nvii\r\navian (pigeon) vestibular HCs. Whole cell patch clamp on both type I and type II HCs indicated that mAChR activation decreased …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… receptors. These cells could also fire action potentials when stimulated electronically. However spontaneous action potentials were not observed. In contrast, pre-differentiated neurons derived from iPS cells fired evoked and spontaneous action potentials. Furthermore, iPS cell-derived neurons …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
The effects of hypotonic shock upon membrane C1 permeability of ROS 17/2.8 osteoblast-like cells was investigated using the patch-clamp technique. Hypotonic shock produced cell swelling that was accompanied by large amplitude, outwardly rectifying, currents that were active across the entire …
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The Effects of Neuropathy-Inducing Organophasphate Esters om Chick Dorsal Root Gangli Cell Cultures
… concentrations and changes in mitochondrial transmembrane potential (DYm) following exposure to neuropathy-inducing OP compounds, suggesting that mitochondrial dysfunction occurs. The present dissertation proposed an investigation using chick embryo DRG cultures to explore early mechanisms …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… cyclic nucleotides, calcium, and resting membrane potentials, on the stiffness of the neuronal environment. CGMP levels were elevated, calcium flickers more dynamic, and resting membrane potential more depolarized in neurons grown on soft, as compared to stiff, substrates. Given what is …
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Computations of object motion in the visual cortex of the ferret
… In this study we investigated the population membrane potential (PMP) and spiking activity (SA) of the neurons in the visual cortex of 6 adult female ferrets in response to natural stimulation. Up- and downwards moving white squares on a random dot background were presented to the …
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Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
… open over the entire range of physiological membrane potentials. Heteromeric TASK-1/3 channels are critical to oxygen sensing in carotid body type 1 cells, where hypoxia-induced inhibition of TASK-3 and/or TASK-1/3 potassium currents leads to voltage-gated calcium entry, exocytotic …