Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Membrane Interactions"”.
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Pathogen Membrane Interactions
… amplipathic molecules interact with lipid membranes through electrostatic and hydrophobic interactions. Natural antimicrobial peptides and their synthetic derivatives are amphipathic molecules with broad-spectrum antimicrobial activity, but the underlying mechanism needs clarification. We …
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Deterministic design of peptide-membrane interactions
… of the physical integrity of cell plasma membranes leading to depolarization, leakage, and eventual cell death. This thesis provides a detailed molecular model how AMPs destabilize membranes specifically, based upon their fundamental structural motif: they are amphipathic and cationic. …
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The isolation, structure, and membrane interactions of biologically active peptides.
… uses solid-state NMR to detail the dynamic interactions of fallaxidin 4.1a with artificial lipid bilayers, and to explore the surface interactions of the peptides with eukaryotic (neutral) and prokaryotic (anionic) membranes. The solid state NMR and analysis using a quartz crystal …
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Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains
Toxin-membrane interactions are poorly understood on the molecular level due to the inherent difficulty of crystallizing membrane protein complexes and the large size (>50 kDa) of most functional AB or MARTX protein toxins. Toxins can interact with membranes at three stages during intoxication: 1) …
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Dynamics of protein-membrane interactions in drug metabolism and cancer
The cell membrane forms a critical barrier between the environment and the inner biochemical machinery of every life form on earth. Without the membrane, vital metabolic processes almost certainly could not occur. Many of these processes also require proteins present at or even embedded within the …
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Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition
… effect of HAMLET, (3) characterize the membranes response to HAMLET and the perturbation of membrane associated signaling cascades, (4) use proteomic screens to identify conserved features of HAMLET targets in tumor cells. Elucidating the structure of HAMLET is important to understand …
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Analytical methods for the study of membranes and peptide-membrane interactions
… peptide (human neutrophil defensin HNP-2) to membranes, using methods that included dichroism and fluorescence spectroscopy, demonstrated that HNP-2 dimers act on lipid membranes via a carpet-type mechanism and allowed the rate of the formation of bound HNP-2 states to be determined. HNP-2 was …
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Effects of Osmolytes on Amyloid-beta Protein Surface Activity and Membrane Interactions
… activity and favorable interaction with lipid membranes can induce the formation of fibrils, suggesting a possible membrane-based mechanism of Aβ aggregation in Alzheimer's disease. Unlike dilute solutions used for in vitro experiments, the cellular environment is highly crowded, with …
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Model membrane interactions with ions and peptides at the air/water interface
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated biochemical processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. …
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The disordered N-terminus of RLIP76: a hub for protein and membrane interactions
… third of RLIP76, reminiscent of poly-basic membrane binding motifs. Attachment of RLIP76 directly to membranes, rather than localisation via other proteins, has never been assessed. Liposomes were therefore used as an in vitro tool to investigate mem- brane binding. The ability of RLIP76 to …
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THE ROLE OF CORONAVIRUS - HOST CELL MEMBRANE INTERACTIONS DURING VIRAL ENTRY AS MEDIATED BY CONSERVED REGIONS OF THE FUSION PEPTIDE
… and fusion of the virus with the host cell membrane, a process orchestrated by the Spike (S) protein. Within the S, the fusion peptide (FP) is a short, highly conserved domain that inserts into the host membrane, initiating membrane fusion, genome release and subsequent infection. Due to its …
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Experimental simulation of human islet amyloid polypeptide (hIAPP)-pancreatic beta cell membrane interactions: Inferences and implications in the etiopathogenesis of diabetes mellitus type II
… hIAPP peptide fragment and pancreatic beta cell membrane interactions, and it uses density functional methods and circular dichroism spectroscopic analysis of the hIAPP molecule to uncover factors that initiate and promote progression of beta cell death. Results from our study establish the …
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A Study of The Effect of Membrane Targeting Antimicrobial Compounds on Ionic Transport Across Lipid Bilayer Membranes
… properties through studying their peptide-membrane interactions. Melimine has previously been shown to reduce the integrity of membranes, observed through the leakage of dye from bacterial membranes. The membrane-peptide interactions were compared using advanced lipid membrane biophysical …
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Insights into Mechanisms of Amyloid Toxicity: Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and Islet Amyloid Polypeptide (IAPP)
… (Aβ); Aβ exerts its toxic effects through interactions with neuronal cell membranes. A characteristic feature of T2D is the deposition of the islet amyloid polypeptide (IAPP) in the pancreatic islets of Langerhans. It is currently unknown if IAPP aggregation is a cause or consequence of …
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A Survey of Beta-Sheet Folding: WW Domains With Zinc Fingers and Membrane Peptides
… our work we summarize ongoing research on the membrane interactions of a small alpha-helical peptide.
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Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
… cause the toxicity in AD and PD through aberrant interactions with lipid membranes. Despite current significant effort, the link between αS-/Aβ42-membrane interactions and disease mechanisms remains elusive. In this work, I applied a set of bulk and microfluidic assays to address this problem by …
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pH-Triggered Membrane Insertion of Proteins
Several classes of membrane proteins refold from their original soluble conformations in response to acidification and insert into lipid bilayers. Despite the recent advances in unraveling the molecular mechanisms of pH-triggered insertion of membrane proteins, many aspects of this process remain …
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… to investigating how specific protein-ligand interactions in the active site affect selectivity and affinity of inhibitors; how ATP-competitive inhibitors affect membrane binding of PI3Kα; how known membrane binding inhibitors of coagulation factor V and VIII C2 domains affect PI3Kα- membrane …
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Partitioning and Diffusivity of arsenic(III) in the Active Layer of Thin-Film Composite Reverse Osmosis and Nanofiltration Membranes
… a neutral molecule (arsenic (III)) through RO/NF membranes. The permeation of potassium iodide (KI), used as background electrolyte, was also investigated. This study introduced Rutherford backscattering spectrometry (RBS) into the membrane field. Major achievements were made from three …
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MECHANISTIC STUDY OF AQUAPORINS BEHAVIOR UNDER DIFFERENT MICROENVIRONMENTS
… of optimally functioning Aquaporin-based membranes requires further understanding on the interactions between AQPs and the membrane matrix. As such this project is designed to provide biological understanding on the complex nature of AQPs-membrane interactions which is identified by …
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