Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Membrane Excitability"”.
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NKAINs: A Novel Family of Membrane Proteins that Interact with the Na, K-ATPase and Affect Membrane Excitability
… in the genome. Aside from the conserved transmembrane domains, NKAINs contain no known functional domains. Striking amino acid conservation in the first two transmembrane domains suggests that the function of these proteins is concentrated in the membrane bilayer. NKAIN1, 2, 3 and a splice …
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Activity-dependent integration and plasticity of new neurons during postnatal neurogenesis
… channels to selectively alter the intrinsic excitability of new neurons in vivo, this manipulation reveals that neuronal survival critically depends on the level of membrane depolarization. Once neurons integrate and survive in the brain circuits, neurons have the capability of monitoring …
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Status Epilepticus Results in a Duration-Dependent Increased Protein Kinase A Activity in the Rat Pilocarpine Model
… that could lead to the maintenance of increased membrane excitability. SE was induced by injection of pilocarpine after which rats were monitored both electrographically and behaviorally. After various lengths of time in SE, specific brain regions were isolated for biochemical study. SE resulted …
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Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
… calcium channels play critical roles in membrane excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 gene by the …
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K(ATP) channel Kir62 subunit distribution differs between muscles and between fiber types in skeletal muscle
… to couple the metabolic state of a cell to its membrane excitability, is important in several tissues for the maintenance of glucose homeostasis and cytoprotection. In skeletal muscle specifically, the channel has been shown to be involved in cell volume regulation, modulation of glucose uptake, …
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The role of Polo-like kinase 2 in synaptic function and plasticity
… scaling in dissociated culture and for reducing membrane excitability in slice culture-two principal compensatory mechanisms underlying homeostatic plasticity. Inhibition of Plk2 activity in slice culture during elevated activity resulted in increased dendritic spine size and density as well as a …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… of migraine pain by modulating neuronal membrane excitability. There are two orexin receptors that differentially bind orexin peptides. Single and dual orexin receptor antagonists have been synthesized to selectively block the activity of these orexinergic receptors. I hypothesized that a …
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Regulation of a two-pore K+ channel by multiple subunits in Caenorhabditis elegans
… and show that SUP-18 is a type-three transmembrane protein that colocalizes with SUP-9 in muscle membranes and whose intracellular domain is similar to bacterial NADH nitroreductases that use an FMN cofactor. We identified a mutation in a predicted FMN-binding residue of SUP-18 that both …
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Alkalosis and digoxin effects on plasma potassium, ionic homeostasis and exercise performance in healthy humans
… which may contribute to impaired muscle cell membrane excitability and fatigue. The magnitude of K+ changes are dependent on the size of contracting muscle mass, duration and intensity of exercise, and health and fitness status of participants. Activation of the sarcolemmal and t-tubular bound …
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Examining the relationship between mitochondrial dysfunction and Parkinson's disease pathology: a review on potential risk factors and treatments for parkinsonism
… functions, and are critically important for membrane excitability and neurotransmission. Past evidence indicates that mitochondrial dysfunction plays a significant role in the progression of degenerative pathologies in the brain. In this review, genetic factors and biochemical mechanisms …
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The role of redox oscillation in circadian physiology of the suprachiasmatic nucleus and hippocampus
… the rhythm in redox state appears to modulate membrane excitability in hippocampal CA1 neurons. Our results demonstrate that 1) the SCN redox oscillation is a modulator of circadian physiology at the level of phase-shifting response to light, 2) the circadian redox oscillation shows …
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Characterization of the Role of Differential Gene Expression and RNA Editing in Drosophila Tonic and Phasic Motoneuron Diversity
… subtypes leads to their unique morphology, membrane excitability and synaptic properties is poorly understood. Protein expression and function within neurons depends on numerous transcriptional and post-transcriptional regulatory steps, which can be controlled at a single cell level. Using …
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Structural and functional heterogeneity of cells in the rat hippocampus
… significantly influences hippocampal neuronal excitability and functions in both CA1 and DG, including long-term potentiation, memory acquisition, and recall of learned tasks (Chaudhury et al., 2005). However, mechanisms underlying these diurnal changes are still an open question. Preliminary …