Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Membrane Destabilization"”.
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Holin-dependent secretion of a large clostridial cytotoxin by C. perfringens
… for C. difficile and P. sordellii share similar membrane topologies to that of the phage lambda holin. However, TpeE in C. perfringens shares a similar membrane topology to TatA, a key protein in the Twin Arginine Transport (Tat) secretion system. This thesis tests two models, a pore-forming …
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Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
… SC cultured in euglycemic conditions, lysosomal membrane destabilization preceded mitochondrial membrane depolarization, oxidative stress and caspase 3/7 activation. The release of cathepsin L and B were also observed with PA treatments. However, in hyperglycemic SCs, PA-LTx induced- ER stress …
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Deterministic design of peptide-membrane interactions
… effects. A general mechanism of AMP activity is destabilization of the physical integrity of cell plasma membranes leading to depolarization, leakage, and eventual cell death. This thesis provides a detailed molecular model how AMPs destabilize membranes specifically, based upon their fundamental …
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Cellular interaction with novel biomaterials
… cell proliferation appears to be through membrane destabilization. Tissue culture well plates coated with PLETESA allowed cells to adhere in a concentration dependent manner, multilaminar liposomes possibly of PLETESA were observed in solution in PLETESA coated wells. Polyhydroxybutryate …
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Characterizing uptake, distribution and fate of CdSe/ZnS quantum dots in Synnechococcus elongatus PCC7942
… of quantum dots on cells, cell growth rate, membrane destabilization, viability and the activity of photosynthetic pigments were characterized. For characterization of uptake and distribution, flow cytometry, laser scanning confocal microscopy and transmission electron microscopy were used. …
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Host cell death in Legionella pneumophila pathogenesis and immunity
… host cell, <em>L. pneumophila</em> resides in a membrane-bound vacuole, in which the bacterium evades lysosomal fusion and replicates. The establishment of the vacuole requires the Dot/Icm (Defect in organelle trafficking/ intracellular multiplication) transport system, which translocates a large …
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Mechanistic study on the therapeutic strategy to enhance glioma cell death through inhibition of proteasome and lysosome
… Taken together, our results suggest that the membrane destabilization of accumulated lysosomes and the resultant release of lysosomal proteases may critically contribute to the irreparable damage of various organelles and glioma cell death by kaempferol plus CQ. In this study, we show that …
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Theoretical and computational investigations of membrane associated molecular pathology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms