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Showing 1 to 20 of 28 for “"Membrane Depolarization"”.

  1. Modulation of Kras Structure and Dynamics By Kras Ubiquitination and Membrane Depolarization

    Nair, Vinay, <p><strong> 0000-0002-1090-4711 </strong></p>2023

    … of KRAS with its regulators, effectors, and the membrane present one such avenue. In this study, we investigated how post-translational covalent and environmental modifications could modulate these interactions of KRAS. Using computational molecular dynamics simulations, nuclear magnetic …

    uthsc Repository record

  2. Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12

    Nashat, Amir Hossein, 1973-Massachusetts Institute of Technology2003

    … the effects of different patterns of membrane depolarization on undifferentiated pheochromocytoma (PC 12) cells. In response to chronic depolarization, cytoplasmic free Ca2+ ([Ca2+]i) levels increased transiently, then decreased to intermediate levels that were maintained for more than …

    mit Repository record

  3. Interaction of Colicin Ia With Escherichia Coli: I. Mechanisms of Colicin Insensitivity. Ii. Inhibition of Colicin Binding by Phenolic Uncouplers

    Weaver, Craig AllenUniversity of Illinois at Urbana-Champaign2014

    … are insensitive to colicin Ia, cytoplasmic membrane vesicles prepared from a TonB strain are sensitive to colicin-induced membrane depolarization. This finding shows that the TonB function is not required for channel formation and maintenance within the cytoplasmic membrane, but, instead, is …

    uiuc Repository record

  4. Understanding Primate Immunity to African Trypanosomes Through the Characterization of Trypanosome Lytic Factor Formation and Function

    Fresard, SaraThe Graduate School and University Center of The City University of New York2025

    … trypanosome, APOL1 inserts into the endosomal membrane due to the acidic pH. Some APOL1 is trafficked to the lysosome, and some to the plasma membrane via the recycling endosome. APOL1 on the surface opens a non-selective cation channel due to the neutral pH. This channel allows sodium and …

    cuny-grad Repository record

  5. Characterization of Luteinizing Hormone - Releasing Hormone (Lhrh) Release From Rat Hypothalamus Using an in Vitro System

    Hartter, Daryl EdwardUniversity of Illinois at Urbana-Champaign2014

    … LHRH release, an effect attributed to nerve membrane depolarization triggering influx of Na('+) and Ca('++) ions and resulting in exocytosis of LHRH. K('+)-evoked LHRH release was strongly Ca('++)-dependent; however, Na('+) influx was not obligatory in depolarization-induced release. In …

    uiuc Repository record

  6. Slow Inactivation of Sodium Channels: Structural Clues and Disease Associations

    Webb, Jadon Ray2010

    … rapidly inactivate to a refractory state during membrane depolarization, in a process known as 'fast inactivation'. During sustained membrane depolarization or prolonged busts of discharges, channels can further inactivate to non-conducting states collectively referred to as 'slow inactivation'. …

    utswmed Repository record

  7. Uncovering New Mechanisms of Type III CRISPR-Cas System Inhibition and Effector Function

    Cahir, Clare Wen2027

    … of the Cap1 effector, composed of a pair of transmembrane helices (TM1/2), a CARF-like (CARFL) domain and a domain of unknown function (DUF4579). Cryo-EM studies on apo-and ligand-bound states of Cap1 in glyco-diosgenin detergent revealed the formation of tetrameric complexes in both states, with …

    rockefeller Repository record

  8. Molecular mechanisms of synaptic plasticity

    Hwang, HongikMassachusetts Institute of Technology2016

    … allows a sustained influx of calcium during the membrane depolarization in hippocampal neurons. Our results indicate that dynamic changes in neurogranin levels play a crucial role in setting the threshold for inducing LTP in spike-timing-dependent plasticity in the hippocampus.

    mit Repository record

  9. Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle

    Chaplin, Nathan L., author, Amberg, Gregory, advisor, DeLuca, Jennifer, committee member, Tamkun, Michael, committee member, Tsunoda, Susan, committee memberColorado State University. Libraries2015

    … active channels, whose activity increases with membrane depolarization. The number of channels gating in this manner is increased by activation of angiotensin receptors on the cell membrane, and basal L-type channel activity is increased during hypertension. Reactive oxygen species are also …

    colostate Repository record

  10. Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells

    Padilla, Amelia

    … SC cultured in euglycemic conditions, lysosomal membrane destabilization preceded mitochondrial membrane depolarization, oxidative stress and caspase 3/7 activation. The release of cathepsin L and B were also observed with PA treatments. However, in hyperglycemic SCs, PA-LTx induced- ER stress …

    loma-linda Repository record

  11. Activity-dependent integration and plasticity of new neurons during postnatal neurogenesis

    Lin, Chia-WeiMassachusetts Institute of Technology2010

    … survival critically depends on the level of membrane depolarization. Once neurons integrate and survive in the brain circuits, neurons have the capability of monitoring their activity level and adaptively maintain their membrane excitability within the operational range. How they achieve the …

    mit Repository record

  12. Mechanistic Study of Antimicrobial Cyclic Peptide [R4W4] Antibacterial Effectiveness against Methicillin-resistant Staphylococcus aureus (MRSA)

    Akinwale, Ajayi2026

    … assays to evaluate zeta potential, cytoplasmic membrane depolarization, and Lipoteichoic acid (LTA) binding affinity. [R<sub>4</sub>W<sub>4</sub>] exhibits bactericidal activity against bacterial isolates (MBC/MIC £ 4), with a synergistic effect with gentamicin against <em>E. coli</em> …

    chapman Repository record

  13. Role of SH3 and Cysteine-Rich Domain 3 (STAC3) in Skeletal Muscle Development, Postnatal Growth and Contraction

    Cong, XiaofeiVirginia Tech2016

    … to electrical stimulation, high [K+]-induced membrane depolarization, and caffeine and 4-chloro-m-cresol (4-CMC) activation of ryanodine receptor (RyR). Frequent electrostimulation-, high [K+]-, 4-CMC- and caffeine-induced maximal tensions in Stac3-deleted muscles were approximately 20%, 29%, …

    vt Repository record

  14. Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes

    Hung, Hsiao-YuUniversity of British Columbia2008

    … by L-type Ca2+ channels (Cav1.2). Briefly, membrane depolarization opens voltage-gated Cav1.2 to allow for the influx of extracellular Ca2+ into the cytosol. This small sarcolemmal (SL) Ca2+ influx is necessary for triggering a larger release of Ca2+ from the intracellular Ca2+ storage site, …

    ubc Repository record

  15. Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA

    Karanauskaite, JovitaDepartment of Clinical Sciences, Lund University2008

    … techniques such as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. The presence of ATP sensitive channel on the cell membrane …

    lund Repository record

  16. Reactive Oxygen Species-Induced Necrotic Cell Death

    Xie, RuiyuThe University of Arizona.2009

    … Ca2+ concentrations, loss of mitochondrial membrane potential, and subsequent necrotic cell death. Interestingly, PARP-1 hyperactivation was not accompanied by the translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus, a process usually associated with …

    arizona-thes Repository record

  17. A deadly hug : contact-dependent killing by Caulobacter crescentus, via cell surface-associated glycine-zipper proteins

    García-Bayona, LeonorMassachusetts Institute of Technology2017

    … inhibition is widespread. Using a cationic membrane stain, I showed that the Cdz bacteriocin causes inner membrane depolarization in the target cells. To further characterize the mechanism of delivery and toxicity, I conducted a suppressor screen to identify mutations that confer Cdz …

    mit Repository record

  18. Small gtp-binding proteins in insulin secretion

    Jayaram, Bhavaani2011

    … or siRNAs of Arf6 or ARNO reduces both GSIS and membrane depolarization induced insulin release in clonal β-cell line; [iii] secinH3, a selective inhibitor of ARNO/Arf6 signaling pathway, also inhibits GSIS in INS 832/13 cells and rodent islets; [iv] insulinotropic concentration of glucose …

    wayne-thes Repository record

  19. Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription

    Chen, Liang-Fu2017

    … both under basal conditions and following membrane depolarization in primary hippocampal neurons, via a mechanism that involves enhancer recruitment of Brd4, increased transcriptional elongation by the release of paused polymerase, and prolonged activation of Fos promoters. These data …

    duke Repository record

  20. Divalent Effects on Permeatin and Gating of T-type calcium channels

    Lopin, Kyle V.Case Western Reserve University School of Graduate Studies2013

    … their intracellular ion composition and their membrane potential. Voltage gated calcium channels change both of these properties by allowing Ca2+ to enter the cell, causing membrane depolarization and the entry of Ca2+ which acts as important signaling molecule. Much research over the last few …

    ohiolink Repository record

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