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Showing 1 to 4 of 4 for “"Melt Granulation"”.
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Optimization of granule size and tablet properties in a twin screw granulator: the influence of process and formulation parameters
… and other associated processing costs in wet granulation is a benefit of melt granulation. However, twin screw hot melt granulation is rarely applied in most industries. This work details the product characteristics and optimization from melt granulation of the model materials, calcium …
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Novel Carbopol-Wax Blends for Controlled Release Oral Dosage Forms
… processing difficulties of carbopol using hot melt granulation process and to develop sustained release oral formulations of a basic (Propranolol HCl) and an acidic drug (Glipizide).</p> <p>Hot melt granulation was used to prepare free-flowing, directly compressible carbopol-wax blends. …
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A novel solvent-free high shear technology for the preparation of pharmaceutical cocrystals
High shear melt granulation (HSMG) is an established technology for a production of densified granules. In this project, it was used as a novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to …
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Hot-melt extrusion: A versatile pharmaceutical technology
Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid …