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Showing 1 to 20 of 21 for “"Melioidosis"”.
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Identification and Characterization of Novel Melioidosis Vaccine Candidates
Burkholderia pseudomallei, the causative agent of melioidosis, is a CDC Tier 1 select agent. This facultative intracellular, Gram-negative pathogen is highly infectious via the respiratory route, and can cause severe, debilitating and often fatal diseases in humans and animals. At present, no …
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The effect of glibenclamide on the pathogenesis of melioidosis
Melioidosis is an important cause of community-acquired sepsis, endemic to Southeast Asia and Northern Australia. Melioidosis is caused by the soil saprophyte, Burkholderia pseudomallei, a motile Gram-negative bacillus, and is associated with a mortality rate that approaches 50% in Northeast …
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Development of Diagnostic Assays for Melioidosis, Tularemia, Plague and COVID19
… and Yersinia pestis are the causative agents of melioidosis, tularemia and plague, respectively. These bacteria pertain to the United States of America Federal Select Agent Program as they are associated with high mortality rates, lack of medical interventions and are potential agents of …
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Development of Au-Pt Nanoflowers as Nanoenzyme for Highly Sensitive Immunoassay: Application to the Detection of Melioidosis Biomarker
… envelopes of Burkholderia pseudomallei causing Melioidosis, an infectious disease of global health concern. Utilizing the inherent peroxidase-like activity of Au-Pt NFs, we developed Nano-Enzyme Linked Immunosorbent Assay (N-ELISA) and Lateral Flow Immunoassay (LFIA) techniques for on-site and …
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Antibody-based diagnostics and therapeutics for Zaire ebolavirus and Burkholderia pseudomallei
… agents of Ebola virus disease (EVD) and melioidosis, respectively. Early diagnosis is critical for halting the spread of the disease or providing treatment of the disease. Current diagnosis for EBOV includes polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) for …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… and the causative agents of glanders and melioidosis. At present, effective vaccines for the prevention of glanders, or melioidosis in humans, are not available. However, renewed attention has been directed toward developing Burkholderia vaccines because of the pathogens' seemingly ideal …
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Genetic Control of Survival and Weight Loss during Pneumonic Burkholderia pseudomallei (Bp) Infection
… aerobe and the causative agent of the disease melioidosis. Melioidosis is an infectious disease that occurs in humans and animals and is prevalent in Southeast Asia, northern Australia and other tropical areas. Transmission occurs through direct contact with the organism via ingestion, …
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THE BIPC MINOR TRANSLOCASE MEMBRANE PROTEIN OF THE BURKHOLDERIA TRANSLOCON
… pseudomallei is the causative agent of melioidosis, a disease that impacts humans along with some animals. Melioidosis causes severe infections that have diverse manifestations. Melioidosis infection is very difficult to diagnose and treat causing victim’s long periods of suffering. …
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Characterization of the Burkholderia mallei ∆tonB Mutant and its Potential as a Backbone Attenuated Strain for Vaccine Development
… acute inhalational mouse models of glanders and melioidosis infection. Compared to wild type, the B. mallei ΔtonB exhibits slower growth kinetics, siderophore hypersecretion and the inability to utilize hemin, hemoglobin and myoglobin as iron sources. A series of animal challenge studies showed …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for vaccine development. Previous studies have shown …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… pathogen and the etiological agent of melioidosis. Because of intrinsic multi-drug resistance, lack of effective treatment and high case-fatality rates, this organism is classified as a Tier 1 Select Agent and considered a priority for vaccine development. Previous studies have shown …
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Predicting Toxin-Antitoxin Systems Responsible for Host-Induced Persistence of Burkholderia pseudomallei
… is the infectious agent that causes the disease. Melioidosis. The mortality rate for Melioidosis is up to 40% regardless of treatment. Despite the ability of certain antibiotics to reduce mortality, infection relapse occurs in 15-23% of treated patients. The inability of antibiotics to clear a …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
… is an opportunistic soil pathogen that causes melioidosis, a life-threatening human disease prevalent in Southeast Asia, northern Australia, the Middle East, Africa, and South America. The organism also causes disease in plants and animals. Persons with severe melioidosis usually die of …
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Contribution of Secretion Systems to Macrophage Polarization and Cell Death During Burkholderia pseudomallei Infection
… environmental saprophyte and causative agent of melioidosis. As a facultative intracellular pathogen, B. pseudomallei uses secretion systems as primary virulence factors. The type 3 secretion system (T3SS) is used to escape the phagosome while the type 6 secretion system is responsible for …
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Novel Applications of Geospatial Analysis in the Modeling of Infectious Diseases
… in Chapter 2, by forecasting the incidence of melioidosis in Australia given weather forecasts a year prior. We also evaluate the efficacy of this technique and explore the impact of environmental variables such as elevation on melioidosis. But these techniques are not limited to free-living …
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Investigation of dendritic cells as a vector for vaccine delivery
… This bacterium is the causative agent of melioidosis, a disease endemicto areas of south-east Asia and northern Australia, to which presently no licensed vaccine exists.<br></br><br></br>Purified DC were pulsed with heat-killed (HK) whole cell <i>B. pseudomallei</i> and used to immunise …
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Infections of Drosophila melanogaster with pathogens: Mycobacterium marinum and Burkholderia thailandensis
… pseudomallei, the causative agent of melioidosis. The study revealed that B. thailandensis was pathogenic in the fly; it activated the fly immune system and antimicrobial peptides were expressed. Despite the strong immune response, this infection is lethal and kills Drosophila within …
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Protein mis-folding and human disease
… invasion. This bacterial infection causes melioidosis disease in<br/>humans. To determine the ligand recognition site of BipD, its high-resolution crystal<br/>structure has been determined at 1.5Å. This high resolution BipD structure is more<br/>complete than its previously solved …
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Prophylaxis of disease caused by bacterial pathogens of man
… Australia and other tropical areas of the world. Melioidosis has recently appeared in temperate zones, including mainland France and the UK possible as a consequence of increased international travel. Acute disease can be treated with antibiotics but the bacterium can persist in the host and …
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Structural studies of Burkholderia pseudomallei invasion protein D (BipD), 2,4'-dihydroxyacetophenone dioxygenase (DAD) and L-threonine dehydrogenase (TDH)
… infectivity, but also causes the disease melioidosis, which can kill within 48 hours. The structure of this novel protein was determined by MAD phasing methods to 2.1 A, and has been found to be highly homologous with IpaD from Shigella flexneri. This knowledge has enabled proposals to be …
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