Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Melatonin receptor"”.
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Associations of Single Nucleotide Polymorphisms in the Bovine Prolactin, Melatonin Receptor 1A, and Dopamine Receptor D2 Genes with Hair Coat Shedding Scores and Productivity Traits in Beef Cattle
… has been associated with reproductive traits, melatonin receptor 1a (MTNR1A) has been associated with meat quality traits, and the dopamine receptor D2 (DRD2) gene has been associated with hair coat score (HCS) in cattle. Our objective was to determine associations between mutations in the PRL, …
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Effect of Zolpidem, Zaleplon, and Ramelton on cognitive functioning after awakening from napping
Non-benzodiazepine sedative hypnotics and melatonin receptor agonist hypnotics induce the onset of sleep and are primarily prescribed for the treatment of insomnia. Although, non-benzodiazepine sedative hypnotic drugs zaleplon (Sonata) and zolpidem (Ambien) are not chemically like benzodiazepines, …
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The role of melatonin in red wine-induced cardioprotection
… The aim of the study was to explore whether melatonin, recently discovered in red wine, may play a vital role in red wine-induced cardioprotection. Furthermore, we propose that the protective effect may be mediated via the activation of the survivor-acting factor enhancement (SAFE) pathway …
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Investigation of the Signaling Mechanisms of the Pineal Hormone Melatonin in the in Vitro Rat Suprachiasmatic Nucleus
… SCN controls production of the pineal hormone, melatonin, thereby restricting its release to the nighttime. The SCN, in turn, expresses high-affinity receptors for melatonin, and melatonin can feed back to the SCN to regulate its timing. This study sought to examine the signaling pathways and …
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Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs: Pharmacological Evaluation in Phenotypically Diverse Breast Cancer Models and Pharmacokinetic Assessment in Liver Microsome and Female Mouse Models
… is a first-generation selective estrogen receptor modulator, which reduces the risk of both invasive and non-invasive breast cancer (BC) as well as tumor recurrence in several clinical trials. However, chronic use of tamoxifen can increase uterine cancer risk and induce tamoxifen …
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A Mechanistic Evaluation of how Melatonin Enhances Alkaline Phosphatase Activity in Human Adult Mesenchymal Stem Cells
… the purpose of this study was to determine melatonin's role and subsequent mechanism(s) involved in differentiating human adult mesenchymal stem cells (hAMSCs) into osteoblasts as assessed by alkaline phosphatase activity (ALP) and determine whether receptor compartmentalization facilitates …
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Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury
Introduction: The presence of melatonin in wine contributes to the cardioprotective effect of regular and moderate consumption of wine against lethal ischemia/reperfusion injury. Recently, the presence of melatonin isomers has been identified in red wine, but whether or not these isomers confer any …
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Characterising the role of GPR50 in neurodevelopment and lipid metabolism
G-protein coupled receptor 50 (GPR50) is a genetic risk factor for psychiatric illness. It is a member of the melatonin receptor family, which includes the well characterised melatonin receptors 1 and 2 (MT1 and MT2). However, the ligand for GPR50 remains elusive and little is known about GPR50 …