Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Melanomas"”.
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Quantitative analysis of neuropilin-2 expression in pigmented lesions and melanoma
… tissue samples of nevi, primary melanomas, and metastatic melanomas. Sample RNA was extracted and converted to eDNA. Quantitative RT-PCR was then used to amplify eDNA and appropriate normalizations were performed. Luciferase RNA was added at the start of processing as an exogenous …
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In-vitro- und In-situ-Analyse des Tumorsuppressorgens hp19 ARF in malignen Melanomen
… gene and expression of hp19ARF protein in melanomas, we screened eight human melanoma cell lines and primary human melanocytes by RT-PCR, sequencing and immunoblotting. All melanoma cell lines analyzed expressed wild-type hp19ARF mRNA as well as protein. Hp19ARF expression was investigated …
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Aspects of skin cancer diagnosis in clinical practice
… for 1,717 cases of excised skin tumours (252 melanomas, 1,395 naevi and 70 seborrhoeic keratoses (SK)). The overall NNE value during the study period was 6.5 (SKs not included). When SKs were included in the calculations the NNE was 6.8. The NNE value decreased with increasing age of the …
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Halting the neural progression of cancer
… in tissue sections from mice implanted with melanomas that overexpressed SEMA3F compared to control tumors or in mice lacking Nrp2 compared to wildtype (WT) mice with both copies of the gene. In vitro, neurite outgrowth and repulsion assays were conducted in the presence of SEMA3F or SEMA3A. …
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Genetic alterations defining human primary melanoma and mechanisms of immune evasion
The somatic mutations found in melanomas reflect the biological processes that govern tumour development. They also help shape how tumours evolve and escape immune regulation. Studying these changes can therefore help to refine our understanding of melanoma progression with the added potential to …
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… subcutaneous and pulmonary alphaGal-negative B16 melanomas in mice. Furthermore, adoptively transferred lymphocytes from mice vaccinated with the B16alphaGal vaccine elicited a therapeutic response in mice bearing pulmonary tumors. In an attempt to increase the efficacy of the B16alphaGal vaccine, …
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<i>In Vivo</i> Murine Melanoma Tumor Responses to Nanosecond Pulsed Electric Field Treatment
… Tx, nsPEFs produced broad impacts on the melanomas <em>in vivo</em>, ranging from DNA fragmentation, caspase activation, nuclear damage, apoptosis induction, damage to pre-existing infra-tumoral vessels and neovascular inhibition. These tumor responses were expressed by histological and …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay between liver NKT cells and NK cells in resistance to liver metastases from intraocular melanomas. NKT cell-deficient CD1d-/- mice and WT C57BL/6 mice treated with anti-CD1d …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… upregulation of mRNA translation in APOE2 melanomas relative to APOE4 melanomas. After experimental examination of the effects of APOE variants on melanoma translational efficiency, I report the discovery that APOE2 acts in a gain-of function manner to enhance pro-tumorigenic protein …
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Evaluating the use of Dermoscopy in the Primary Care Setting in Improving Clinical Outcomes in the Treatment of Melanoma: A Systematic Review
… setting, and those not concerning melanomas/pigmented skin lesions were excluded. Twenty studies met review criteria, but the heterogeneity of the outcomes measured precluded performance of a meta-analysis, thus data were synthesized in a narrative review. The use of …
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Exploring the Unique Characteristics of Cancer in Adolescents and Young Adults in Tennessee
… The five main cancer types were breast cancers, melanomas, thyroid cancers, lymphomas, and testicular cancers and accounted for over 50% (N=4,269) of cancers in AYAs in Tennessee during the study period. Females were significantly more likely to be diagnosed with melanomas (age adjusted incidence …
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Oncogenic mutation of GNAQ/11 disrupts melanocyte biology in a Zebrafish model of uveal melanoma
… zebrafish develop both uveal and cutaneous melanomas with nearly complete penetrance, causing early lethality. Furthermore, immunohistochemical analysis (IHC) reveals that these melanomas do indeed recapitulate the human disease in that they drive expression of oncogenic GNAQ and show …
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An experimental study of human melanoma cells cutured in vitro
… phenotypic differences that exist between melanomas, to define respects in which melanoma cell differentiation could be modulated and to correlate biochemical variability with in vivo behaviour as measured in the nude mouse. Melanoma cell lines were established from biopsy material obtained …
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Trace element concentrations in melanotic swine
… may play an important role in the formation of melanomas. In this work, neutron activation analysis and x-ray fluorescence analysis were used to determine trace element concentrations in cancerous, noncancerous and normal swine skin samples and in non-cancerous and normal swine tissue samples. …
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Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models
… also relevant to a low-‐MITF subclass of human melanomas that emerged from a recent classification by The Cancer Genome Atlas Network. In addition, I established that, similarly to the BRAFV600Emitfavc7, complete inhibition of MITF activity leads to rapid tumour regression, but once its activity …
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Role of vascular remodeling in the accumulation, clearance, and biodistribution of biomolecular factors in melanoma
… and curative treatment options for advanced melanomas.
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Investigation of key non-coding and coding genes in cutaneous melanomagenesis
… expressed miRNAs between benign naevi and melanomas (7 downregulated, 2 upregulated in malignancies) were verified by qRT-PCR and the functions of four of these miRNAs were studied. Ectopic overexpression of miR- 200c and miR-205 in A375 melanoma cells inhibited colony forming ability in …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
… (V600E) in a significant fraction of cutaneous melanomas, leading to constitutive activation of the MAP kinase pathway. This genetic lesion endows tumor cells with proliferative and survival advantages, and metastatic melanoma patients treated with the BRAF(V600E)-specific inhibitor, …
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New perspectives on melanoma: The role of PAX3
… By contrast PAX3 is frequently found in melanomas and naevi, and its expression correlates with melanoma staging. In this study we explore the multiple roles of PAX3 in melanocyte genesis and melanoma progression. While PAX3 is known to regulate melanocyte differentiation, survival, …
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