Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"Melanoma cells"”.
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RNA-sequence analysis of human melanoma cells
… complementary DNA fragments of cultured human melanoma cells are sequenced and a total of 139,501,106 million 200-bp reads from two samples affected with the disease are obtained. The RNA-seq is performed by first mapping the sequence reads to the reference human genome sequence (NCBI 36.1 …
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Copper ionophores induce autophagy in melanoma cells.
Malignant melanoma is a particularly aggressive form of skin cancer, for which the only current treatment option is excision. As melanoma is an inherently antiapoptotic model of cancer, other avenues of cell death were pursued, namely autophagy, a mechanism in which a cell devours itself in times …
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Optimisation of the isolation and identification of circulating melanoma cells
Although melanoma is largely curable when detected in its earliest stages, it can metastasise to other tissues, drastically reducing survival rates. The most recent therapies used to treat metastatic melanoma are effective long-term in only 11 to 33% of patients. Our ability to monitor treatment …
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An experimental study of human melanoma cells cutured in vitro
… to examine the biology of human malignant melanoma cells cultured in vitro. The studies were so planned as to document phenotypic differences that exist between melanomas, to define respects in which melanoma cell differentiation could be modulated and to correlate biochemical variability …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
The metastatic process requires that tumour cells are capable of traversing various micro-environmental barriers, such as the basement membrane. There are various proteolytic mechanisms which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase …
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Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology
Melanoma is one of the most aggressive and inherently resistant cancers and the most dangerous skin cancer. While it accounts for fewer than 5% of skin cancer cases, 80% of skin cancer related deaths are attributed to melanoma. While resection remains the gold standard for melanoma treatment, …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase expression and activity and TRP-1, TRP-2 expression were suppressed by IFN-γ, which resulted from the inhibition of MITF expression, upstream …
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Characterization of a plasminogen activator from human melanoma cells cultured in vitro
… activator, Mel-PA, that is released by human melanoma cells cultured in vitro. This enzyme was compared to the urinary plasminogen activator, urokinase. The human melanoma cell line, RPMI-7272, (also referred to as the "Bowes" melanoma cell line) released large amounts of Mel-PA into the …
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PAX3 expression, protein modifications and downstream target gene profiling in melanocytes and melanoma cells
… adult melanocytes, naevi and in most melanoma cells. This implies that PAX3 may be involved in such regulatory pathways in all of these cell types including melanoma. Melanoma is a notoriously aggressive and drug resistant form of skin cancer. Research into the role of PAX3 in melanoma …
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
A major goal of studying melanoma is to identify therapeutic vulnerabilities that can be exploited to improve patient treatment. Melanoma cells are particularly sensitive to perturbations in ion homeostasis, especially when ion gradients are perturbed in combination with MAP kinase inhibition. I …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
Melanoma is known to be highly resistant to chemotherapy. Treatment with high dose IL-2 has shown significant clinical benefit in a minority of metastatic melanoma patients and has lead to long term survival in a few cases. However, this treatment is associated with excessive multiorgan toxicities, …
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Analysis of ether-à-go-go potassium channel (Eag1) splice variants in melanoma cells
Der menschliche Ether-à-go-go Kaliumkanal (hEag1) nachgewiesen werden in adulten Gehirn und in beiden Tumorzelllinien und primären Tumoren. Das physiologische Funktion dieses Kanals im Gehirn bleibt zu aufgeklärt. Die Anwesenheit von hEag1 in Tumoren hat zu einem Anstieg in Verbindung gebracht …
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Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
Malignant melanoma causes the highest mortality rate in skin cancers. Although cisplatin has proved efficacious in the treatment of various solid tumors, melanoma seems particularly resistant to this chemotherapeutic drug. Reports show that melanoma patients whose tumors express nitric oxide (NO) …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… administered to determine the effects on B16F10 melanoma cells evaluated by <em>in vitro</em> studies. Initial application of nsPEFs demonstrated apoptosis induction in an electric field- and pulse number-dependent manner measured by caspase activation that correlated with decrease in cell …
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Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
… tailored to largely avoid damage to noncancerous cells. The drawback herein is that intravenous injections leave most of the patients' tissue prone to photodamage for long periods of time following tumor treatment. In this study, we investigated the effect of augmenting current photodynamic …
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Nano- and Micro-Second Electrical Pulsing of B16-F10 Mouse Melanoma Cells: Plasma Membrane and Sub-Cellular Organelle Changes
<p>High electric field-treated cells are permeable to molecular dye through either opening of pores in the plasma membrane or other unknown processes which can disturb the membrane in an organized way. However, direct morphological evidence is lacking and responses of intracellular organelles are …
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Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses
… nanosecond electric pulses (nsEPs) on metastatic melanoma are still unclear. Hence, we applied one, two, three, and four 300 ns 40 kV/cm pulses to murine B16-F10 melanoma cells. Cell attachment ability was determined by comparing the number of floating cells and the percentage of attached cells. …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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