Global ETD Search
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Showing 1 to 3 of 3 for “"Melanoma Brain Metastases (MBMs)"”.
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
<p>Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An …
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… RNA-sequencing analysis of murine intracranial melanoma tumors that pharmacologic inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of this dissertation is that OXPHOS …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… (RNA-seq) analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this …