Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 584 for “"Melanoma"”.
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Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
Melanoma, a potentially lethal form of skin cancer, is widely thought to be immunogenic in nature. While numerous studies have examined T cell-mediated immune responses to melanoma and their therapeutic potential, there has been less focus on B cell-mediated immune responses and the tumor-reactive …
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Chemoprevention of Familial Melanoma
… be used for prophylactic treatment of familial melanoma by being specifically toxic to melanocytes and activating an immune response against distant pigment cells. Cytotoxic experiments reveal that similar to 4-TBP, MBEH induces specific melanocyte death. To compare death pathways initiated by …
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Analisi Molecolare del Melanoma
We have analyzed the proteomes of two human melanoma cell lines (A375 and 526), and of the human melanocytes, (FOM 78), by two-dimensional electrophoresis (2D-PAGE) and liquid chromatography¿tandem mass spectrometry (LC-MS/MS). Our comparative proteomic analysis revealed that six proteins were …
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Drivers of melanoma susceptibility
Cutaneous melanoma is a cancer of melanocytes, the pigment-producing cells in our skin. It is one of the most aggressive human malignancies, constituting only about 2% of all dermatological cancers but being responsible for over 75% of all deaths from skin cancer. It has recently become a major …
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Pax3 expression in cutaneous malignant melanoma
… PAX3 re-expression in cutaneous malignant melanoma (CMM). The transcription, factor encoded by PAX is amongst the first expressed in the embryo, with a principal role in the development of the melanocytic lineage. We theorised that abnormal re-expression of PAX3, consistently observed in …
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Ruolo del gene AIRE nel melanoma
… expression of tissue-specific antigens including melanoma-associated antigens (MAAs), may variably affect the selection of MAAs-specific thymocytes, generating T-cell repertoires protecting or predisposing individuals to melanoma. We found that AIRE single nucleotide polymorphisms (SNPs) …
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Platelet surface receptors and melanoma metastasis
Ziel dieser Arbeit war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. …
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Molecular detection of melanoma nodal metastases
… maximum specificity for the detection of melanoma nodal metastases. A novel protocol for the efficient homogenisation of nodal tissue was developed, with clinical applicability as the objective.
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Suppression of Ca2+ Signaling Enhances Melanoma Progression
… the role of store-operated Ca2+ entry (SOCE) in melanoma metastasis is still not fully elucidated. To address this, we examined UV-dependent metastasis, revealing a critical role for SOCE suppression. As previous literature demonstrated a role for cholesterol (CHL) in melanoma progression, our …
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RNA-sequence analysis of human melanoma cells
… complementary DNA fragments of cultured human melanoma cells are sequenced and a total of 139,501,106 million 200-bp reads from two samples affected with the disease are obtained. The RNA-seq is performed by first mapping the sequence reads to the reference human genome sequence (NCBI 36.1 …
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Copper ionophores induce autophagy in melanoma cells.
Malignant melanoma is a particularly aggressive form of skin cancer, for which the only current treatment option is excision. As melanoma is an inherently antiapoptotic model of cancer, other avenues of cell death were pursued, namely autophagy, a mechanism in which a cell devours itself in times …
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The role of osteopaths in the recognition of melanoma : attitudes, knowledge and practices in melanoma screening within the osteopathic community
Background: Melanoma has the highest mortality rate of skin cancer in New Zealand, and has the third highest incidence rate of cancer overall. The severity of melanoma can be reduced through early detection, which can be achieved through early recognition of suspicious lesions. Osteopaths are …
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Attachment Ability and Melanoma Inhibitory Activity mRNA Expression Level Changes in Murine B16-F10 Melanoma Cells Post Nanosecond Electric Pulses
… nanosecond electric pulses (nsEPs) on metastatic melanoma are still unclear. Hence, we applied one, two, three, and four 300 ns 40 kV/cm pulses to murine B16-F10 melanoma cells. Cell attachment ability was determined by comparing the number of floating cells and the percentage of attached cells. …
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A Translational Study Evaluating the Uses of Diagnostic and Therapeutic Practices Established in Human Malignant Melanoma in Equine Malignant Melanoma
Malignant melanoma is a neoplasm of melanocytes. It typically originates in skin, but may metastasize to other body systems. It is a relatively common neoplasm in both humans and horses, with striking similarities across both species. Heritable genetic factors associated with melanoma have been …
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New perspectives on melanoma: The role of PAX3
Background: Cutaneous melanoma is an aggressive form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 is critical for the proper development of neural crest lineages including melanocytes. Melanocytic cells show continued PAX3 expression from melanoblast formation in …
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Characterizing The Role of Uchl5 In Metastatic Melanoma
<p>Metastatic melanoma is one of the most aggressive cancers. In recent years, the survival rate has improved with the introduction of immunotherapy. Our lab conducted an <em>in vivo</em> ORF screen to identify potential drivers of metastasis. UCHL5/UCH37 was identified as one of the top …
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Clinical and Therapeutic Significance of Obesity In Melanoma
… of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, <em>de novo</em> and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to both targeted and immune …
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Quantifying T cell Mediated Killing for Melanoma Immunotherapy
Adoptive cell therapy (ACT), based on the adoptive transfer of tumor-infiltrating lymphocytes (TILs) has well-recognized advantages such as (1) high specificity for target cells; (2) the ability to target even micrometastases; (3) the potential to proliferate in vivo within the host thus increasing …
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