Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Melanocytes"”.
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Synthesis and activity of tyrosinase in mouse skin melanocytes
… control of melanin sythesis was explored in skin melanocytes of the following strains; wild type (C57BL/6J-C/C) (which maximally synthesize melanin at normal mammalian body temperature, Himalayan (C57BL/6J-cʰ/cʰ) (which maximally synthesize melanin at temperatures below 37°C) and albino (Balb …
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Transformation of human melanocytes and mechanisms of melanoma metastasis
… described, it is demonstrated that human dermal melanocytes, transformed by the introduction of the SV40ER, hTERT, and RasG12V genes, form primary tumors that are invasive and highly metastatic to secondary sites in the body. Moreover, the anatomical sites of metastasis exhibited by the melanoma …
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Melanoblasts and Melanocytes in Canine Fetal Skin and Oral Mucosa
Made available in DSpace on 2014-12-09T22:30:18Z (GMT). No. of bitstreams: 1 6901317.pdf: 6195824 bytes, checksum: 33e19f158a6ed43f002b380c7d5ee50b (MD5) Previous issue date: 1968
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Studies on the Granule-Moving System of Melanocytes of Fundulus Heteroclitus
<p>Pigment granules in melanocytes of Fundulus heteroclitus exhibit both local movements and long distance intracellular migrations in response to hormones. These movements have been studied and a theory of the granule moving system has been proposed: The granules are in a structured continuum …
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Wnt Inhibitory Factor (WIF)-1 Promotes Melanogenesis in Normal Human Melanocytes
… study available on melanogenesis effect of human melanocytes. Objectives: In this study, we investigated the expression of WIF-1 in human melanocytes and the effects of WIF-1 on melanogenesis. Method: To determinutese whether WIF-1 is expressed in human melanocytes, we used immunocytochemistry, …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… are closely related to melanogenesis in melanocytes. Here, I studied whether IFN-γ affects melanogenesis, and if so, what is the underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase expression …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
… in human skin. Recently, it was reported that melanocytes not only function melanin synthesis but also act as immunocompetent cell. Melanosome and melanin in melanoyctes have antimicrobial function. In this study, we focused that microbial induced pigmentation may be related to TLRs in human …
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
… that 3 subtypes of PPAR are expressed in human melanocytes and activators for PPAR-α and PPAR-γ modulates melanocyte growth and melanogenesis. In this study, I investigated the effects of PPAR-γ activators on melanocyte growth and apoptosis. I further examined the regulation of extracellular …
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PAX3 expression, protein modifications and downstream target gene profiling in melanocytes and melanoma cells
… It plays a major role in the development of melanocytes in the embryo. As a result of alternative splicing, the gene gives rise to eight different transcripts which encode proteins that have differing structures and are therefore likely to activate different downstream target genes. The …
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Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin
… in the basal layer of the epidermis are melanocytes, the pigment producing cells of the epidermis. Melanocytes produce melanin pigment which resides in melanosomes, organelles that are transferred to keratinocytes. In my thesis work, I focused on identifying downstream results of …
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Regulation of melanogenesis in conditionally immortalised mouse melanocytes expressing a temperature-sensitive SV40 large T antigen
… formation generated by transforming mouse melanocytes with exogenous oncogenes have revealed that this process is frequently accompanied by a loss of pigmentation. The aim of this study was to establish, and to make use of unique cell lines to gain further insight into the mechanism(s) by …
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Defining Gene Expression in Normal Human Epidermal Keratinocytes and Melanocytes: A Prerequisite for Understanding Hyperplastic and Neoplastic Pathology
… genomic methods that study gene expression of melanocytes and keratinocytes in growth-activated or neoplastic skin diseases. Historically, mRNAs isolated from cultured epidermal keratinocytes or melanocytes are used to define normal gene expression patterns. In this study, we profiled global …
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An in vitro investigation of the effect of Khellin and UVA (KUVA) on normal and transformed human melanocytes
… a human melanoma cell line (Mel-1), normal human melanocytes and 3T3 mouse fibroblasts. Cell proliferation assays revealed that the proliferation of melanoma cells and melanocytes were increased after exposure to khellin for four days at concentrations ranging from 1nM to 0.5mM. A peak of …
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An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing
… of the skin. This is due to the loss of melanocytes. The lack of pigmentation in the healed wound is particularly prominent in dark-skinned individuals and could result in serious psychosocial consequences such as low self-esteem, stigmatisation and discrimination among sufferers. Methods …
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An ultrastructural and light microscopic study of melanocyte differentiation in chick embryos
… directing the in vivo differentiation of melanocytes from crest cells are as yet unknown. To begin to address this issue, it is important to establish exactly when and where these signa/s first exert their effects. Therefore, in the present study, overtly differentiated melanocytes …
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Wnt Modulators, Secreted Frizzled Related Protein (sFRP) 2 and Wnt Inhibitory Factor (WIF)-1, Stimulate Melanogenesis in Normal Human Melanocytes
… differentiation as well as the development of melanocytes. Previous studies showed that hyperpigmentary skins of melasma express high levels of frizzled-related protein 2 (sFRP2) and Wnt inhibitory factor-1 (WIF-1) compared to perilesional normal skins. In this study, I investigated the …
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Birds of a white feather : a congenital hypopigmentary disorder in the chick
… by addressing the following two questions: are melanocytes present in the skin regions and feather follicles in normal numbers of 8- to 13-day white chick embryos? If melanocytes are present in normal numbers, are they unable to synthesise pigment because of a defect in melanocyte …
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New perspectives on melanoma: The role of PAX3
… form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 is critical for the proper development of neural crest lineages including melanocytes. Melanocytic cells show continued PAX3 expression from melanoblast formation in the neural crest to their …
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