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Showing 1 to 13 of 13 for “"Melanocortin Receptors"”.
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Design, Synthesis, And Testing Of Multivalent Compounds Targeted To Melanocortin Receptors
… to over-express α-melanocyte stimulating hormone receptors. A successful multivalent construct should show greater avidity towards melanoma cells than healthy cells due to the synergistic effects arising from multivalency. Both oligomeric and shorter linear constructs bearing the minimum active …
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Analyzing the Interactions Between Xenopus tropicalis MC2R, MC5R, and the MRAPs: Modeling the Regulation of Frog Interrenal Cells
<p>The role of Melanocortin 2 Receptor (MC2R) in adrenal/interrenal glucocorticoid secretion has been well documented in many organisms. Studies in mammals have shown that in the adrenal gland two melanocortin receptors and two melanocortin receptor accessory proteins are expressed: MC2R, MC5R, …
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Characterization of MC3 and the other melancortin receptors (MC) in the hypothalamo-pituitary-gonadal system of the mouse
Melanocortin receptors (MC, MC1–MC5) are GPCRs, activated with different affinities by the melanocortin peptides (α-, β-, γ-MSH and ACTH). MC3 has well characterised roles in both the central regulation of energy metabolism and peripheral inflammatory responses. The functions and distribution of …
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Exercise-induced alterations in melanocortin receptor expression and inflammation
… novel in that it explores the expression of the melanocortin receptors (MCR) on the plasma membranes of systemic monocytes, indicating a novel role for the MCRs as anti-inflammatory receptors that are regulated by chronic exercise training. The melanocortin 1 receptor (MC1R) and melanocortin 3 …
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Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes
Melanocortin peptides are endogenously produced peptides originating from the posttranslational processing of the pro-opiomelanocortin hormone (POMC), exerting their effect by binding to class A G-protein-coupled 7 transmembrane domain receptors, positively coupled to adenylate cyclase. To date …
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Characterization of the Whale Shark (Rhincodon Typus) Melanocortin-2 Receptor
<p>Among bony vertebrates, the melanocortin-2 receptor ortholog is unique among the family of five melanocortin receptors on the basis that it is dependent on its accessory protein, MRAP1, for trafficking and activation, and is selective for activation by ACTH alone. Previous studies on the MC2R …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… data, I identified Mc5r, encoding the fifth melanocortin receptor (Mc5r), as expressed more highly by ILC2 than ILC3. Treatment of mice with the neuropeptide alpha-melanocortin-stimulating hormone (αMSH), an agonist for melanocortin receptors, induced increases in the proportions of lung NK …
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Preparation of polysaccharide-based nanoemulsions to reduce melanoma drug resistance and inflammation markers
… and used to target A375 cells. Subsequently, the melanocortin type 1 and 3 receptor agonists BMS-470539-dihydrochloride and [DTrp8]-γ-MSH were delivered to A375 cells using folate-modified pullulan-chitosan nano-emulsion, to target regulation of iNOS and COX-2 as important markers in melanoma …
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Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
The five melanocortin receptors (MC (1-5)) are part of the G-coupled protein receptor (GPCR) family and have been reported to have a role in controlling appetite, modulating inflammation and stress response. The melanocortin receptor accessory proteins (MRAP1 and 2) influence MC receptor transport …
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The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
Melanocortin peptides, which act on melanocortin receptors (MCRs), play multifaceted roles in the body through various tissues and mechanisms that regulate physiological functions. MCRs, comprising a family of five subtypes (MC1R to MC5R), are 7-transmembrane receptors that can couple with G …
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Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes
… treatment solutions for OA. Therefore, the melanocortin system, comprised of melanocortin peptides could provide a novel treatment option for OA. Melanocortin peptides are endogenous pro-opiomelanocortin-derived peptides that display potent anti-inflammatory effects via the activation of the …
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The Multifunctional Melanocortin System in the Human Choroid
… melanin in response to UV exposure, mediated by melanocortin ligand-receptor (α-MSH/MC1R) signalling. The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) activates melanocortin receptors (MC1R to MC5R) and receptor accessory proteins (MRAPs), forming the melanocortin system. α-MSH can …
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From genomics to function: Canine genetics highlight novel mechanisms of obesity and related traits
… in both dogs and humans. The hypothalamic melanocortin receptors (MCR) are central to the control of energy homeostasis across species. The first investigations in this thesis aimed to better understand the role of canine MCR genes in obesity. Missense variants MC3R p.M320I and MC4R p.V213F …