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Showing 1 to 11 of 11 for “"Meis1"”.
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The Role of Meis1 in Hematopoietic Development
… ecotropic viral integration site 1: <italic>Meis1</italic>).</p><p>Meis1 forms a heterodimer with Pbx1 that augments Hox-dependent gene expression. In addition, <italic>Meis1</italic> has been associated with leukemogenesis and hematopoietic stem cell self-renewal. In examining potential …
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
… energy demands. Furthermore, we demonstrate that Meis1 and Hif-1α are markedly enriched in HSCs and that Meis1 functions upstream of the two master redox regulators Hif-1α and Hif-2α, where loss of Meis1 results in a metabolic shift from glycolysis to mitochondrial oxidative metabolism, and …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… new therapeutic approaches are in urgent needs. Meis1 (myeloid ecotropic viral integration site 1) gene belongs to the three-amino-acid loop extension subclass of homeobox gene families, and it is a highly conserved transcription factor in all eukaryotes. Up to date, little is known about the …
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Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
… tumor suppressive co-transcription factor, MEIS1, yielding dysregulation of proteoglycans consistent with a loss-of-function HOXB13 status. The G84E mutation resulted in faster onset and progression of 22Rv1 tumor xenografts in SCID mice and were confirmed to have a significant reduction in …
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A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum
… expression of transcription factors Irx3, Meis1, Meis2, and Lhx2/9 defines neurons of the CN, and that the combinatorial expression of Lhx1 and Lhx5 defines Purkinje cells, as these distinct neural classes exit the cell cycle. We also show that Meis1 is a new marker for granule cell …
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Significance of Protein Interactions in Mediating AF9 Function
… of some MLL target genes such as HOXA9 and MEIS1, and enhanced proliferation of hematopoietic progenitors. MLL chimeras do not retain the histone methyltransferase activity of wild type MLL and it is unclear how they deregulate the expression of MLL target genes.</p><p>AF9 is one of the most …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… Of these, Bmi1 and, to a lesser extent, Pbx1 and Meis1 overexpression in JAK2-mutant HSCs could improve stem cell self-renewal, allowing development of a disease phenotype in functional assays. Together, these findings refine the molecules involved in clonal expansion of MPNs, and highlight the …
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
… express HOXA5, A9, A10, B2, B3, and MEIS1 in a canonical, highly coordinated pattern that is virtually identical to that found in normal human CD34 cells. HOX gene "dysregulation" in these cases may therefore represent the persistence of a normal, stem cell-specific HOX gene …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… and expression of MLL target genes Hoxa9 and Meis1 compared to MLL-AF9(WT). Coimmunoprecipitation studies show that the D546R mutation in the context of amino acids 376-568 of AF9 significantly reduces binding to Dot1l while maintaining interaction with Af4. These results indicate that …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… of the leukemic transcription factors, Hoxa9 and Meis1. These findings explain why E2A-PBX1-driven bone marrow transplant models fail to generate B-lymphoid disease and suggest that future efforts in developing a model of E2A-PBX1-driven pre-B ALL leukemia should focus on expressing E2A-PBX1 …
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Investigation of DNA methylation at the promoter region of the aralkylamine N-acetyltransferase (AANAT ) gene in South African children with Autism Spectrum Disorder
… (zinc finger protein with interaction domain), MEIS1 (Meis homeobox 1) and ZIC1 (zinc finger protein of the cerebellum 1) were identified at or near to CpG 3. These three TFs have known gene ontology terms that relate to neurodevelopment. The age of participants did not correlate with DNAme, and …