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Showing 1 to 7 of 7 for “"Meiotic prophase I"”.
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Study of meiotic chromosomal structure and molecular mechanisms of meiotic prophase I
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Higher Order Chromosome Organization and Recombination Dynamics of Meiotic Prophase I In Mouse Spermatocytes
<p>Meiotic recombination is required for parental chromosomes to find each other (pairing/synapsis) and to exchange genetic information thus allowing faithful segregation of chromosomes and the production of haploid gametes. At the start of meiotic prophase I, meiotic chromosomes organize into loop …
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Gene expression changes during mammalian male meiotic initiation
… haploid gamete generation. Germ cells undergo meiotic initiation, the transition from the mitotic cell cycle to the meiotic cell cycle, once in a generation. In mammals, genetic studies have identified key regulators of meiotic initiation. However, a holistic assessment of the transcriptional …
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Sexually dimorphic Argonaute localization underlies sex-specificity of small RNA pathways during germ cell development
… PGL-1 and ZNFX-1, through all stages of meiotic prophase I. These analyses highlight the highly dynamic properties of AGOs, and how these biophysical attributes differ between oogenesis and spermatogenesis at distinct stages of germ cell development. I further reveal that native WAGO-1 …
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MODELING INFERTILITY: SINGLE GENE MUTATIONS AND CONSEQUENCES FOR GERM CELL DEVELOPMENT
… HORMA-domain proteins and is essential for meiotic progression. Pathogenic mutations of TRIP13 are found in humans and cause infertility via oocyte maturation arrest. In Chapter 2, we used a genetic approach and imaging techniques to study the function of TRIP13 in meiotic prophase I in …
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A molecular characterization of the meiotic initiation factor STRA8 in mice
… haploid gametes. In most organisms, accurate meiotic chromosome segregation depends on the pairing and synapsis of homologous chromosomes and crossing over during prophase of meiosis I. These chromosomal events are generally conserved across eukaryotes and have been extensively studied. In …
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Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… In humans and mice, among other organisms, meiotic recombination promotes but also relies upon pairing between homologs. Interhomolog pairing is required for completion of meiotic recombination. The mutual dependence and differential reliance between recombination and pairing in well-studied …