Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Megalin"”.
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… densely located in the medulla, and suggest that megalin, a saturable endocytic membrane transporter, may be largely responsible for aminoglycoside accumulation. Despite the overwhelming evidence for a significant role of megalin in aminoglycoside accumulation, the complete mechanism of uptake has …
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The role of megalin in the transport of aminoglycosides across human placenta
… be vulnerable to the nephrotoxic effects of AGs. Megalin, a 600 kDaendocytic receptor, is responsible for the uptake of AGs into renal proximal tubular epithelial cells. This receptor is also expressed in human term placenta and it is reasonable to speculate that it is similarly involved in the …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… on the expression of protein endocytic receptor megalin and its impact on proteinuria, particularly in obesity is not known. There are indications suggesting the involvement of glycogen synthase kinase (GSK)-3β-mediated megalin phosphorylation, and its subsequent endocytosis and lysosomal …
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… apical vesicles in the biosynthetic pathway. Megalin, a member of the low density lipoprotein family of receptors, is sorted apically in polarized epithelial cells via a sorting signal present in its cytosolic domain. I show that the cytosolic domain of megalin associates with sorting nexin …
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Vitamin B12 Bioconjugates In Pharmaceutical Design
… <p>Q3: (Chapter 4) Are functional cubilin and megalin receptors expressed in human fetal small intestinal cells?</p> <p>Goal: Design a fluorescent assay to establish functional cubilin and megalin expression and conduct western blotting to complement observations.</p> <p>Q4: (Chapter 4) Does …
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TDI 천식 기도염증반응과 관련된 활성산소의 역할
… of FITC-VDBP into RLE-6TN cells by TDI 44 2. Megalin mediated the endocytic uptake of FITC-VDBP into RLE-6TN cells 46 3. Downregulation of megalin mRNA and protein by TDI treatment in RLE-6TN 49 4. Decreased 1,25(OH)2D3 production by TDI 51 5. Increased VEGF production and secretion through …
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Novel Interactions of the Hormone Leptin Revealed by PET Imaging in Rodents and Rhesus Macaques
… of the multiligand endocytic transporter megalin revealed loss of leptin in the urine, which was confirmed using PET imaging. Thus, megalin is required for the uptake of leptin in the proximal convoluted tubule within the cortex of the kidney. Subsequent biodistribution experiments …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… MRP2, PEPT2, and endocytic receptors (cubilin, megalin), while inducing OCTN1 and MRP1/3. TNF-α reproduced the effects of IL-1β but only on OAT1–3. Functional assays showed concordant IL-1β-driven decreases in OAT1–3, OAT4, and OCT2 activity and increased OCTN1 activity. Mechanistic experiments …